SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.77A 1hrkA-5lxgA:
undetectable		 1hrkA-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.77A 1hrkB-5lxgA:
undetectable		 1hrkB-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.89A 2po5A-5lxgA:
undetectable		 2po5A-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 212
HIS A 341
HIS A 337
HIS A 191
 None
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
 1.01A 3ljgA-5lxgA:
undetectable		 3ljgA-5lxgA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 214
GLY A 211
PHE A 186
ILE A 250
ALA A 249
 None
 1.07A 3uwlD-5lxgA:
undetectable		 3uwlD-5lxgA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A 352
GLY A 354
SER A 356
PRO A 222
PHE A 173
 None
 1.49A 3v3nA-5lxgA:
undetectable		 3v3nA-5lxgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 275
LEU A 276
ALA A 268
PHE A 271
 None
 0.82A 5xu8A-5lxgA:
undetectable		 5xu8A-5lxgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 242
LEU A 224
VAL A 350
ALA A 346
LEU A 274
 None
 1.13A 6a7pB-5lxgA:
undetectable		 6a7pB-5lxgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 191
HIS A 337
HIS A 341
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
 0.73A 6giqa-5lxgA:
3.2		 6giqa-5lxgA:
22.28