SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lxr RNA-BINDING PROTEIN
7
(Homo
sapiens) 		5 / 10 ALA A  33
PHE A  57
LEU A  75
VAL A  21
ILE A  80
 None
 1.29A 1claA-5lxrA:
undetectable		 1claA-5lxrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 12 PHE B 286
LEU A  69
PHE B 309
LEU B 299
LEU B 295
 None
 1.17A 1dtlA-5lxrB:
undetectable		 1dtlA-5lxrB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE A  73
ILE A  80
ILE B 291
PHE A  57
VAL A  55
 None
 0.91A 2ygqA-5lxrA:
undetectable		 2ygqA-5lxrA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lxr RNA-BINDING PROTEIN
7
(Homo
sapiens) 		5 / 9 ALA A  33
PHE A  57
LEU A  75
VAL A  21
ILE A  80
 None
 1.23A 3claA-5lxrA:
undetectable		 3claA-5lxrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 12 LEU B 295
ILE A  80
LEU A  70
ILE A  41
PHE A  30
 None
 0.99A 4odrA-5lxrB:
undetectable
4odrB-5lxrB:
undetectable		 4odrA-5lxrB:
14.43
4odrB-5lxrB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5lxr RNA-BINDING PROTEIN
7
ZINC FINGER CCHC
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 11 LEU B 295
ILE A  80
LEU A  70
ILE A  41
PHE A  30
 None
 1.08A 4odrA-5lxrB:
undetectable
4odrB-5lxrB:
undetectable		 4odrA-5lxrB:
14.43
4odrB-5lxrB:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lxr RNA-BINDING PROTEIN
7
(Homo
sapiens) 		4 / 7 VAL A  39
ILE A  41
VAL A  14
ALA A  53
 None
 0.52A 5osrA-5lxrA:
undetectable		 5osrA-5lxrA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5lxr RNA-BINDING PROTEIN
7
(Homo
sapiens) 		5 / 12 LEU A  69
ALA A  33
LEU A  29
ILE A  82
ILE A  80
 None
 1.05A 5xiwD-5lxrA:
undetectable		 5xiwD-5lxrA:
21.21