SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 11 ILE A  53
LEU A 108
GLY A  56
PHE A  76
VAL A  24
 None
 1.45A 1axwB-5lxvA:
undetectable		 1axwB-5lxvA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		3 / 3 VAL A  55
VAL A 107
TRP A  91
 None
 0.91A 1bdwA-5lxvA:
undetectable
1bdwB-5lxvA:
undetectable		 1bdwA-5lxvA:
8.74
1bdwB-5lxvA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 6 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 0.96A 1errB-5lxvB:
undetectable		 1errB-5lxvB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
(Ruminococcus
flavefaciens) 		4 / 8 VAL B 899
ASP B 894
HIS B 938
LEU B 924
 None
CA  B1001 (-2.9A)
None
None
 1.19A 1pk2A-5lxvB:
undetectable		 1pk2A-5lxvB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
(Ruminococcus
flavefaciens) 		4 / 8 VAL B 899
ASP B 894
HIS B 938
LEU B 949
 None
CA  B1001 (-2.9A)
None
None
 1.20A 1pk2A-5lxvB:
undetectable		 1pk2A-5lxvB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 0.98A 2jfaA-5lxvB:
undetectable		 2jfaA-5lxvB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 1.01A 2qxsA-5lxvB:
undetectable		 2qxsA-5lxvB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 LEU B 942
ASP A  77
MET B 907
LEU B 893
 None
 1.01A 2qxsB-5lxvB:
undetectable		 2qxsB-5lxvB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 12 LEU B 924
VAL B 951
VAL B 901
SER A 148
ASN A 144
 None
 1.45A 2y00B-5lxvB:
undetectable		 2y00B-5lxvB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 12 ILE A  37
LEU A 108
ILE A  58
ALA A  59
THR A  61
 None
 0.97A 3a50A-5lxvA:
undetectable		 3a50A-5lxvA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 12 VAL A  89
TYR A  43
SER A  87
GLY A 113
ILE A 111
 None
 1.32A 3a65A-5lxvA:
undetectable		 3a65A-5lxvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 4 LEU B 904
ASP B 933
VAL B 911
THR A  69
 None
 1.15A 3cyxB-5lxvB:
undetectable		 3cyxB-5lxvB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 LYS A 104
VAL A  55
ILE A  58
TYR A 151
 None
 1.47A 3gvuA-5lxvA:
undetectable		 3gvuA-5lxvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 4 ASP A  18
THR A 114
VAL A 171
SER A 117
 None
 1.37A 3wxoA-5lxvA:
undetectable		 3wxoA-5lxvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 12 SER A  79
VAL A  78
GLN A  19
ILE A  50
ASN A  82
 None
 1.41A 4c49D-5lxvA:
undetectable		 4c49D-5lxvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 12 PHE A  20
TYR A  43
SER A  87
VAL A  89
VAL A  78
 None
 1.14A 4ffwB-5lxvA:
undetectable		 4ffwB-5lxvA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 ILE A 102
ARG B 908
ASP A  77
VAL A  24
 None
 1.22A 4nkxC-5lxvA:
undetectable		 4nkxC-5lxvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 5 ILE A 102
ARG B 908
ASP A  77
VAL A  24
 None
 1.20A 4nkxD-5lxvA:
undetectable		 4nkxD-5lxvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		5 / 11 ASP A  51
VAL A  47
TYR A  43
ILE A  80
PHE A  20
 None
 1.29A 5hw8B-5lxvA:
undetectable		 5hw8B-5lxvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5lxv CARBOHYDRATE-BINDING
PROTEIN WP_009985128
(Ruminococcus
flavefaciens) 		5 / 11 GLY B 891
ASP B 892
ALA B 921
PRO B 950
VAL B 899
 None
CA  B1001 (-3.2A)
None
None
None
 1.07A 5yk2A-5lxvB:
undetectable		 5yk2A-5lxvB:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5lxv SCAFFOLDIN C
(Ruminococcus
flavefaciens) 		4 / 8 ILE A   7
ASP A 105
ASP A  28
PRO A  30
 None
 0.98A 6ag0C-5lxvA:
undetectable		 6ag0C-5lxvA:
20.11