SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 GLY B 358
ALA B 357
VAL B 590
GLY B 412
THR B 395
None
0.96A 1c6zA-5lxzB:
undetectable
1c6zA-5lxzB:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 GLY B 358
ALA B 357
VAL B 590
GLY B 412
THR B 395
None
0.92A 1c6zB-5lxzB:
undetectable
1c6zB-5lxzB:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 10 ASP B 428
ALA B 431
ASP B 432
ASP B 433
VAL B 437
None
0.99A 1d4yA-5lxzB:
undetectable
1d4yA-5lxzB:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 LEU B 342
ILE B 409
THR B 395
MET B 384
None
1.30A 1kglA-5lxzB:
undetectable
1kglA-5lxzB:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 LEU B 344
LEU B 397
LEU B 619
GLN B 621
None
1.02A 1kt3A-5lxzB:
undetectable
1kt3A-5lxzB:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 10 ASP B 118
SER B 117
ILE B 134
GLY B 123
GLY B 263
None
None
None
EDO  B 715 (-3.4A)
None
1.30A 1mehA-5lxzB:
undetectable
1mehA-5lxzB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 4 ALA B  72
VAL B  80
ALA B  73
HIS B 124
None
None
None
EDO  B 715 (-3.4A)
1.24A 1q23K-5lxzB:
undetectable
1q23K-5lxzB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 ALA B 357
VAL B 590
GLY B 412
THR B 395
None
0.83A 1t7iB-5lxzB:
undetectable
1t7iB-5lxzB:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 ALA B  52
VAL B 492
TRP B  56
None
0.95A 1tkqA-5lxzB:
undetectable
1tkqA-5lxzB:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 TYR B  49
ARG B 480
GLN B 478
None
0.78A 1tw4A-5lxzB:
undetectable
1tw4A-5lxzB:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 1v54N-5lxzB:
undetectable
1v54P-5lxzB:
undetectable
1v54N-5lxzB:
20.87
1v54P-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.50A 2dyrA-5lxzB:
undetectable
2dyrC-5lxzB:
undetectable
2dyrA-5lxzB:
20.87
2dyrC-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.50A 2dyrN-5lxzB:
undetectable
2dyrP-5lxzB:
undetectable
2dyrN-5lxzB:
20.87
2dyrP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 2eikA-5lxzB:
undetectable
2eikC-5lxzB:
undetectable
2eikA-5lxzB:
20.87
2eikC-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 2eikN-5lxzB:
undetectable
2eikP-5lxzB:
undetectable
2eikN-5lxzB:
20.87
2eikP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.50A 2eilN-5lxzB:
undetectable
2eilP-5lxzB:
undetectable
2eilN-5lxzB:
20.87
2eilP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.47A 2eimA-5lxzB:
undetectable
2eimC-5lxzB:
undetectable
2eimA-5lxzB:
20.87
2eimC-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.47A 2einN-5lxzB:
undetectable
2einP-5lxzB:
undetectable
2einN-5lxzB:
20.87
2einP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 TYR B 289
GLY B 137
THR B 138
TYR B 141
CU  B 701 (-4.7A)
None
None
None
1.02A 2g70A-5lxzB:
undetectable
2g70A-5lxzB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 TYR B 289
GLY B 137
THR B 138
TYR B 141
CU  B 701 (-4.7A)
None
None
None
0.99A 2g70B-5lxzB:
undetectable
2g70B-5lxzB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 ASP B 118
ASP B  99
ASP B  94
None
None
CU  B 702 (-2.1A)
0.71A 2igtA-5lxzB:
undetectable
2igtA-5lxzB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 11 ASP B 428
ALA B 431
ASP B 432
ASP B 433
VAL B 437
None
1.04A 2o4pA-5lxzB:
undetectable
2o4pA-5lxzB:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 PRO B 455
GLY B 511
TYR B 544
None
0.68A 2vouB-5lxzB:
undetectable
2vouB-5lxzB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 PRO B 455
GLY B 511
TYR B 544
None
0.68A 2vouC-5lxzB:
undetectable
2vouC-5lxzB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 2y69A-5lxzB:
undetectable
2y69C-5lxzB:
undetectable
2y69A-5lxzB:
20.87
2y69C-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 TYR B 540
VAL B 492
THR B 541
None
0.88A 2ygnA-5lxzB:
undetectable
2ygnA-5lxzB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 3abkN-5lxzB:
undetectable
3abkP-5lxzB:
undetectable
3abkN-5lxzB:
20.87
3abkP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 3abmN-5lxzB:
undetectable
3abmP-5lxzB:
undetectable
3abmN-5lxzB:
20.87
3abmP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 3ag2A-5lxzB:
undetectable
3ag2C-5lxzB:
undetectable
3ag2A-5lxzB:
20.87
3ag2C-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.50A 3ag3A-5lxzB:
undetectable
3ag3C-5lxzB:
undetectable
3ag3A-5lxzB:
20.87
3ag3C-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.50A 3ag4A-5lxzB:
undetectable
3ag4C-5lxzB:
undetectable
3ag4A-5lxzB:
20.87
3ag4C-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 3asnA-5lxzB:
undetectable
3asnC-5lxzB:
undetectable
3asnA-5lxzB:
20.87
3asnC-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 11 PRO B 614
ARG B 562
VAL B 579
GLY B 634
GLU B 633
None
None
EDO  B 710 (-4.3A)
None
None
1.42A 3bf6H-5lxzB:
undetectable
3bf6H-5lxzB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 4 SER B 503
GLY B 504
GLY B 498
GLY B 463
None
0.86A 3bogB-5lxzB:
undetectable
3bogD-5lxzB:
undetectable
3bogB-5lxzB:
undetectable
3bogD-5lxzB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 LYS B 111
LYS B 276
VAL B 113
None
0.91A 3brfA-5lxzB:
undetectable
3brfA-5lxzB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 ARG B 547
GLU B 490
TYR B 540
None
0.87A 3k37B-5lxzB:
7.2
3k37B-5lxzB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 4 GLY B 249
TYR B 234
GLY B 176
ASP B 232
None
1.23A 3kl3A-5lxzB:
undetectable
3kl3A-5lxzB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 TYR B 289
TYR B 339
HIS B  71
TYR B 501
CU  B 701 (-4.7A)
EDO  B 715 (-4.6A)
None
CU  B 701 (-4.4A)
1.32A 3uzzA-5lxzB:
undetectable
3uzzA-5lxzB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 8 TYR B 289
TYR B 339
HIS B  71
TYR B 501
CU  B 701 (-4.7A)
EDO  B 715 (-4.6A)
None
CU  B 701 (-4.4A)
1.31A 3uzzB-5lxzB:
undetectable
3uzzB-5lxzB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 ILE B 350
ASP B 297
LEU B 295
GLY B 296
ASN B 618
None
EDO  B 713 (-3.3A)
EDO  B 713 (-3.9A)
EDO  B 713 (-3.6A)
None
1.13A 4eb4A-5lxzB:
undetectable
4eb4A-5lxzB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 ILE B 350
ASP B 297
LEU B 295
GLY B 296
ASN B 618
None
EDO  B 713 (-3.3A)
EDO  B 713 (-3.9A)
EDO  B 713 (-3.6A)
None
1.14A 4eb4B-5lxzB:
undetectable
4eb4B-5lxzB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 10 GLY B 358
ALA B 357
VAL B 590
GLY B 412
THR B 395
None
0.95A 4njtB-5lxzB:
undetectable
4njtB-5lxzB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 GLY B 358
ALA B 357
VAL B 590
GLY B 412
THR B 395
None
0.85A 4njvA-5lxzB:
undetectable
4njvA-5lxzB:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 5b1aN-5lxzB:
undetectable
5b1aP-5lxzB:
undetectable
5b1aN-5lxzB:
20.87
5b1aP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.47A 5b1bN-5lxzB:
undetectable
5b1bP-5lxzB:
undetectable
5b1bN-5lxzB:
20.87
5b1bP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 5b3sN-5lxzB:
undetectable
5b3sP-5lxzB:
undetectable
5b3sN-5lxzB:
20.87
5b3sP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 LEU B 144
TYR B 141
TYR B 359
TYR B 216
LEU B 154
None
1.15A 5czyA-5lxzB:
undetectable
5czyA-5lxzB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 4 LEU B 619
ILE B 598
PRO B 400
LEU B 397
None
1.18A 5eb3A-5lxzB:
undetectable
5eb3A-5lxzB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 LEU B 342
ILE B 409
THR B 395
MET B 384
None
1.36A 5ljeA-5lxzB:
undetectable
5ljeA-5lxzB:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
3 / 3 HIS B  71
HIS B 589
HIS B 502
None
CU  B 701 (-3.2A)
CU  B 701 (-3.2A)
1.00A 5oexA-5lxzB:
8.3
5oexA-5lxzB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.47A 5x19N-5lxzB:
undetectable
5x19P-5lxzB:
undetectable
5x19N-5lxzB:
20.87
5x19P-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 LEU B 600
SER B 585
ARG B 580
ILE B 453
ASP B 457
None
None
EDO  B 710 (-2.7A)
None
None
1.49A 6bxnA-5lxzB:
undetectable
6bxnA-5lxzB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 ASP B 428
ALA B 431
ASP B 432
ASP B 433
VAL B 437
None
0.96A 6dilA-5lxzB:
undetectable
6dilA-5lxzB:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 VAL B 280
TYR B 277
PRO B 272
PHE B 270
LEU B 132
None
1.42A 6eliA-5lxzB:
undetectable
6eliA-5lxzB:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 6 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.49A 6nknA-5lxzB:
undetectable
6nknC-5lxzB:
undetectable
6nknA-5lxzB:
20.87
6nknC-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.46A 6nmfN-5lxzB:
undetectable
6nmfP-5lxzB:
undetectable
6nmfN-5lxzB:
20.87
6nmfP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
4 / 7 HIS B  71
ASP B 266
TYR B 277
HIS B 502
None
None
None
CU  B 701 (-3.2A)
1.48A 6nmpN-5lxzB:
undetectable
6nmpP-5lxzB:
undetectable
6nmpN-5lxzB:
20.87
6nmpP-5lxzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 12 ILE B 350
ASP B 297
LEU B 295
GLY B 296
ASN B 618
None
EDO  B 713 (-3.3A)
EDO  B 713 (-3.9A)
EDO  B 713 (-3.6A)
None
1.25A 6r2eA-5lxzB:
undetectable
6r2eA-5lxzB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)
5lxz SECRETED PROTEIN
(Streptomyces
lividans)
5 / 10 ILE B 350
ASP B 297
LEU B 295
GLY B 296
ASN B 618
None
EDO  B 713 (-3.3A)
EDO  B 713 (-3.9A)
EDO  B 713 (-3.6A)
None
1.17A 6r2eC-5lxzB:
undetectable
6r2eC-5lxzB:
20.96