SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ly3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ARG A   9
PHE A 429
PRO A 430
LEU A 417
LEU A 413
 None
 1.26A 1e7wA-5ly3A:
undetectable		 1e7wA-5ly3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		3 / 3 ALA A 158
VAL A 127
TRP A 125
 None
 0.98A 1gmkA-5ly3A:
undetectable
1gmkB-5ly3A:
undetectable		 1gmkA-5ly3A:
3.57
1gmkB-5ly3A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		3 / 3 ALA A 158
VAL A 127
TRP A 125
 None
 1.00A 1gmkC-5ly3A:
undetectable
1gmkD-5ly3A:
undetectable		 1gmkC-5ly3A:
3.57
1gmkD-5ly3A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ASN A 336
LEU A 201
GLY A 200
VAL A 180
MET A 324
 None
 1.12A 1gs4A-5ly3A:
undetectable		 1gs4A-5ly3A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 8 TYR A 138
ASP A  97
TRP A 101
LEU A 131
 None
 1.18A 1pk2A-5ly3A:
undetectable		 1pk2A-5ly3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 PHE A 356
SER A 352
ILE A 192
ILE A 179
 None
 0.98A 1sbrB-5ly3A:
undetectable		 1sbrB-5ly3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ASN A 336
LEU A 201
GLY A 200
VAL A 180
MET A 324
 None
 1.14A 2oz7A-5ly3A:
undetectable		 2oz7A-5ly3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 ASN A 336
LEU A 201
GLY A 200
VAL A 180
MET A 324
 None
 1.07A 2q7lA-5ly3A:
undetectable		 2q7lA-5ly3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 5 SER A 352
LEU A 166
GLY A 405
GLU A 181
 None
None
None
ADP  A 501 ( 4.8A)
 1.04A 3aiaA-5ly3A:
undetectable
3aiaB-5ly3A:
undetectable		 3aiaA-5ly3A:
20.92
3aiaB-5ly3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		3 / 3 ALA A 171
VAL A 407
TRP A 403
 None
 0.86A 3l8lC-5ly3A:
undetectable
3l8lD-5ly3A:
undetectable		 3l8lC-5ly3A:
3.57
3l8lD-5ly3A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 TYR A 147
ALA A 130
LEU A 131
LEU A 104
ILE A 170
 None
 1.15A 3ozwB-5ly3A:
2.8		 3ozwB-5ly3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 GLN A 164
GLU A 181
THR A  20
GLY A 185
GLY A 182
 None
ADP  A 501 ( 4.8A)
ADP  A 501 (-3.1A)
None
None
 1.16A 3tegA-5ly3A:
undetectable		 3tegA-5ly3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 8 GLU A 231
GLU A 235
LYS A 238
ARG A 239
 None
ADP  A 501 (-2.7A)
ADP  A 501 (-2.8A)
ADP  A 501 (-3.4A)
 0.65A 4bqfB-5ly3A:
undetectable		 4bqfB-5ly3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 7 ALA A 130
GLY A 410
ILE A 408
GLY A 405
 None
 0.61A 4eatA-5ly3A:
undetectable		 4eatA-5ly3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 8 ALA A 135
LEU A  88
ARG A  94
TYR A 138
 None
 1.22A 4ijiF-5ly3A:
undetectable		 4ijiF-5ly3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 12 LEU A 351
GLY A 354
ALA A 355
ILE A 187
VAL A 326
 None
ADP  A 501 (-3.1A)
ADP  A 501 (-4.8A)
None
None
 0.95A 4xdrA-5ly3A:
undetectable		 4xdrA-5ly3A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 11 VAL A 234
GLY A 208
GLY A 207
ASN A 186
ILE A 290
 None
ADP  A 501 (-3.4A)
None
None
None
 1.26A 4zvmA-5ly3A:
undetectable
4zvmB-5ly3A:
undetectable		 4zvmA-5ly3A:
18.86
4zvmB-5ly3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 208
GLU A 235
LYS A 238
ARG A 239
GLY A 354
 ADP  A 501 (-3.4A)
ADP  A 501 (-2.7A)
ADP  A 501 (-2.8A)
ADP  A 501 (-3.4A)
ADP  A 501 (-3.1A)
 0.97A 5aqfA-5ly3A:
22.6		 5aqfA-5ly3A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 208
GLU A 235
LYS A 238
ARG A 239
GLY A 354
 ADP  A 501 (-3.4A)
ADP  A 501 (-2.7A)
ADP  A 501 (-2.8A)
ADP  A 501 (-3.4A)
ADP  A 501 (-3.1A)
 0.99A 5aqfC-5ly3A:
22.6		 5aqfC-5ly3A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 208
GLU A 235
LYS A 238
ARG A 239
GLY A 354
 ADP  A 501 (-3.4A)
ADP  A 501 (-2.7A)
ADP  A 501 (-2.8A)
ADP  A 501 (-3.4A)
ADP  A 501 (-3.1A)
 0.94A 5aqyA-5ly3A:
23.5		 5aqyA-5ly3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ly3 ACTIN/ACTIN FAMILY
PROTEIN
(Pyrobaculum
calidifontis) 		4 / 4 GLY A  40
LEU A  63
VAL A  65
GLU A 106
 None
 1.39A 5yw0A-5ly3A:
undetectable		 5yw0A-5ly3A:
21.79