SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ly6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		4 / 7 ASP B  67
ILE B 237
VAL B 240
TYR B 242
 None
 0.86A 3p6hA-5ly6B:
undetectable		 3p6hA-5ly6B:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 ALA B  91
LEU B  89
GLY B  73
ALA B 126
PRO B 118
 None
 1.30A 3tm4A-5ly6B:
undetectable		 3tm4A-5ly6B:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 ALA B  91
LEU B  89
GLY B  73
ALA B 126
PRO B 118
 None
 1.28A 3tm4B-5ly6B:
undetectable		 3tm4B-5ly6B:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 TYR B 242
TYR B 200
VAL B 202
TYR B  71
SER B 203
 None
 1.30A 3uprA-5ly6B:
undetectable		 3uprA-5ly6B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 TYR B 242
TYR B 200
VAL B 202
TYR B  71
SER B 203
 None
 1.32A 3uprC-5ly6B:
undetectable		 3uprC-5ly6B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 TYR B 242
TYR B 200
VAL B 202
TYR B  71
SER B 203
 None
 1.33A 3vriA-5ly6B:
undetectable
3vriC-5ly6B:
undetectable		 3vriA-5ly6B:
21.40
3vriC-5ly6B:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		3 / 3 TRP B 397
TRP B 379
THR B 378
 None
 1.31A 4bboB-5ly6B:
undetectable		 4bboB-5ly6B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		4 / 4 LEU B 327
ILE B 329
GLY B 326
ILE B 198
 None
 0.82A 5dzk3-5ly6B:
undetectable
5dzkm-5ly6B:
undetectable		 5dzk3-5ly6B:
9.52
5dzkm-5ly6B:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		4 / 5 ILE B 329
GLY B 326
ILE B 198
LEU B 327
 None
 0.73A 5dzki-5ly6B:
undetectable
5dzkj-5ly6B:
undetectable
5dzkx-5ly6B:
undetectable		 5dzki-5ly6B:
17.83
5dzkj-5ly6B:
17.83
5dzkx-5ly6B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		4 / 5 ILE B 329
GLY B 326
ILE B 198
LEU B 327
 None
 0.79A 5dzkd-5ly6B:
undetectable
5dzkk-5ly6B:
undetectable
5dzky-5ly6B:
undetectable		 5dzkd-5ly6B:
19.70
5dzkk-5ly6B:
17.83
5dzky-5ly6B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		4 / 4 ILE B 329
GLY B 326
ILE B 198
LEU B 327
 None
 0.77A 5dzkl-5ly6B:
undetectable
5dzkz-5ly6B:
undetectable		 5dzkl-5ly6B:
17.83
5dzkz-5ly6B:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 TYR B 242
TYR B 200
VAL B 202
TYR B  71
SER B 203
 None
 1.30A 5u98A-5ly6B:
undetectable		 5u98A-5ly6B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 TYR B 242
TYR B 200
VAL B 202
TYR B  71
SER B 203
 None
 1.30A 5u98D-5ly6B:
undetectable		 5u98D-5ly6B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5ly6 PNEUMOLYSIN
(Streptococcus
pneumoniae) 		3 / 3 LEU B 292
ILE B 329
TYR B  71
 None
 0.57A 5uunB-5ly6B:
undetectable		 5uunB-5ly6B:
21.97