SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ly8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 6 ILE A  82
TRP A 233
PHE A  94
GLU A 232
 None
 1.49A 1nsiA-5ly8A:
undetectable
1nsiB-5ly8A:
undetectable		 1nsiA-5ly8A:
19.50
1nsiB-5ly8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 6 PHE A 129
VAL A 139
LEU A 157
MET A 152
 None
 1.08A 1wrlB-5ly8A:
undetectable		 1wrlB-5ly8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		3 / 3 PHE A  54
ARG A  99
ASN A 225
 None
 0.89A 1xzxX-5ly8A:
undetectable		 1xzxX-5ly8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 6 ALA A 124
PHE A 181
VAL A 198
PHE A 201
 None
 0.98A 2cizA-5ly8A:
undetectable		 2cizA-5ly8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 7 ILE A  82
TRP A 233
PHE A  94
GLU A 232
 None
 1.47A 2nsiA-5ly8A:
undetectable
2nsiB-5ly8A:
undetectable		 2nsiA-5ly8A:
19.50
2nsiB-5ly8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 7 TRP A 233
PHE A  94
GLU A 232
ILE A  82
 None
 1.47A 2nsiA-5ly8A:
undetectable
2nsiB-5ly8A:
undetectable		 2nsiA-5ly8A:
19.50
2nsiB-5ly8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 8 ILE A 186
TYR A 230
ASP A 184
ARG A 182
 None
 1.07A 2v57A-5ly8A:
undetectable		 2v57A-5ly8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 8 ILE A 186
TYR A 230
ASP A 184
ARG A 182
 None
 1.07A 2v57C-5ly8A:
undetectable		 2v57C-5ly8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 6 LEU A 153
PHE A 181
LEU A 179
PHE A 201
 None
 0.74A 3abkP-5ly8A:
undetectable
3abkW-5ly8A:
undetectable		 3abkP-5ly8A:
20.48
3abkW-5ly8A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		5 / 12 ASN A 101
VAL A 100
ASN A 105
ALA A 133
PHE A 112
 None
 1.44A 3s68A-5ly8A:
undetectable		 3s68A-5ly8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 4 THR A  30
GLY A 208
ASP A 207
SER A  79
 None
 0.71A 4rfqA-5ly8A:
undetectable		 4rfqA-5ly8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 6 ARG A  99
ASN A 169
ASN A 225
GLN A 227
 None
 1.12A 5l6eA-5ly8A:
undetectable		 5l6eA-5ly8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ly8 TAIL COMPONENT
(Lactobacillus
phage
J-1) 		4 / 5 LEU A 153
PHE A 181
LEU A 179
PHE A 201
 None
 0.78A 5x19C-5ly8A:
undetectable
5x19J-5ly8A:
undetectable		 5x19C-5ly8A:
20.48
5x19J-5ly8A:
12.55