SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ly9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 11 ALA A  10
LYS A   1
GLY A 175
THR A 228
ALA A 227
 None
 1.19A 2f16H-5ly9A:
undetectable
2f16I-5ly9A:
undetectable		 2f16H-5ly9A:
22.57
2f16I-5ly9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 11 ALA A  10
LYS A   1
GLY A 175
THR A 228
ALA A 227
 None
 1.18A 2f16V-5ly9A:
undetectable
2f16W-5ly9A:
undetectable		 2f16V-5ly9A:
22.57
2f16W-5ly9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 12 GLY A 188
SER A 119
GLY A 118
GLY A 117
ALA A 129
 None
 0.96A 3douA-5ly9A:
undetectable		 3douA-5ly9A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		3 / 3 ILE A 105
SER A  22
SER A 148
 None
 0.63A 3iltH-5ly9A:
undetectable		 3iltH-5ly9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		4 / 6 SER A 104
ARG A 253
GLU A  27
GLU A 256
 None
 1.02A 3k9fA-5ly9A:
1.2
3k9fB-5ly9A:
1.2
3k9fD-5ly9A:
undetectable		 3k9fA-5ly9A:
20.28
3k9fB-5ly9A:
20.28
3k9fD-5ly9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 11 ALA A  10
LYS A   1
GLY A 175
THR A 228
ALA A 227
 None
 1.17A 3mg0V-5ly9A:
undetectable
3mg0W-5ly9A:
undetectable		 3mg0V-5ly9A:
22.57
3mg0W-5ly9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		3 / 3 LEU A 316
LYS A 313
THR A 312
 NAG  A 402 ( 4.5A)
None
GOL  A 408 (-3.3A)
 0.63A 4lj0A-5ly9A:
undetectable		 4lj0A-5ly9A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 12 SER A  25
GLY A 103
ASP A 106
LEU A 109
TRP A 246
 None
None
GOL  A 406 (-4.8A)
None
None
 1.12A 4pghB-5ly9A:
undetectable		 4pghB-5ly9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		5 / 11 SER A  25
GLY A 103
ASP A 106
LEU A 109
TRP A 246
 None
None
GOL  A 406 (-4.8A)
None
None
 1.20A 4pghC-5ly9A:
undetectable		 4pghC-5ly9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		4 / 7 LEU A  21
LEU A  17
GLU A 248
LEU A 101
 None
 0.81A 4wg0L-5ly9A:
undetectable
4wg0M-5ly9A:
undetectable		 4wg0L-5ly9A:
4.48
4wg0M-5ly9A:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		4 / 4 ARG A 331
ILE A 328
TYR A 353
ILE A  51
 None
 1.41A 5odhG-5ly9A:
undetectable		 5odhG-5ly9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1
(Trypanosoma
brucei) 		4 / 8 LEU A  68
TYR A  71
GLU A 267
THR A 312
 None
GOL  A 408 (-4.1A)
None
GOL  A 408 (-3.3A)
 1.21A 6c71B-5ly9A:
undetectable		 6c71B-5ly9A:
11.41