SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		3 / 3 ALA A 476
VAL A 399
TRP A 397
 None
 0.92A 1c4dC-5lykA:
undetectable
1c4dD-5lykA:
undetectable		 1c4dC-5lykA:
8.57
1c4dD-5lykA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		5 / 10 LEU A 464
ALA A 340
ASP A 341
ILE A 510
GLY A 386
 None
 1.16A 1d4sA-5lykA:
undetectable		 1d4sA-5lykA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		4 / 7 TYR A 441
VAL A 401
GLY A 402
THR A 506
 None
 0.77A 2a1mA-5lykA:
undetectable		 2a1mA-5lykA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		4 / 8 TYR A 441
VAL A 401
GLY A 402
THR A 506
 None
 0.80A 2a1mB-5lykA:
undetectable		 2a1mB-5lykA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		4 / 6 LEU A 371
GLN A 369
ILE A 352
PRO A 368
 None
 0.83A 2fcnA-5lykA:
undetectable
2fcnB-5lykA:
undetectable		 2fcnA-5lykA:
18.13
2fcnB-5lykA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 5lyk BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1
(Homo
sapiens) 		5 / 11 LEU A 464
ALA A 340
ASP A 341
ILE A 510
VAL A 411
 None
 1.34A 3oxxB-5lykA:
undetectable		 3oxxB-5lykA:
15.76