SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 12 VAL A 160
PHE A 188
VAL A 176
ILE A 205
THR A 171
 None
 1.28A 3em0A-5lzkA:
1.2		 3em0A-5lzkA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 11 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.91A 3o5rA-5lzkA:
undetectable		 3o5rA-5lzkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		4 / 6 TYR A 244
MET A 142
ILE A 139
SER A 256
 None
None
EDO  A 307 ( 4.9A)
None
 1.27A 3pmzD-5lzkA:
undetectable		 3pmzD-5lzkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		4 / 7 VAL A 199
MET A 191
LEU A 180
ILE A 178
 None
 1.03A 3rfmA-5lzkA:
undetectable		 3rfmA-5lzkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		4 / 8 VAL A 167
ILE A 166
ILE A 139
PHE A 157
 None
None
EDO  A 307 ( 4.9A)
None
 0.80A 3uqbA-5lzkA:
undetectable		 3uqbA-5lzkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 12 ASP A 159
VAL A 167
ILE A 166
LYS A 136
PHE A 157
 None
 1.12A 4drhA-5lzkA:
undetectable		 4drhA-5lzkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 12 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.69A 4drhA-5lzkA:
undetectable		 4drhA-5lzkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 11 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.81A 4drjA-5lzkA:
undetectable		 4drjA-5lzkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 10 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.92A 4laxA-5lzkA:
undetectable		 4laxA-5lzkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 12 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.83A 4nnrA-5lzkA:
undetectable
4nnrB-5lzkA:
undetectable		 4nnrA-5lzkA:
21.11
4nnrB-5lzkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 10 VAL A 167
ILE A 166
LYS A 136
ILE A 139
PHE A 157
 None
None
None
EDO  A 307 ( 4.9A)
None
 0.94A 4nnrB-5lzkA:
undetectable		 4nnrB-5lzkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 10 ILE A 178
ILE A 205
LEU A 202
HIS A 187
ASN A 186
 None
 1.24A 5vkqA-5lzkA:
undetectable
5vkqD-5lzkA:
undetectable		 5vkqA-5lzkA:
7.45
5vkqD-5lzkA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 10 HIS A 187
ASN A 186
ILE A 178
ILE A 205
LEU A 202
 None
 1.20A 5vkqA-5lzkA:
undetectable
5vkqB-5lzkA:
undetectable		 5vkqA-5lzkA:
7.45
5vkqB-5lzkA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lzk PROTEIN FAM83B
(Homo
sapiens) 		5 / 10 HIS A 187
ASN A 186
ILE A 178
ILE A 205
LEU A 202
 None
 1.20A 5vkqC-5lzkA:
undetectable
5vkqD-5lzkA:
undetectable		 5vkqC-5lzkA:
7.45
5vkqD-5lzkA:
7.45