SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 4 HIS A 324
VAL A 283
ASN A 282
THR A 322
 None
 1.46A 1dy5A-5lzlA:
undetectable		 1dy5A-5lzlA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		3 / 3 TRP A 145
THR A 228
TYR A 229
 None
 1.23A 2a3bA-5lzlA:
5.9		 2a3bA-5lzlA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 160
ALA A 187
ALA A 157
VAL A 124
GLY A 197
 None
 0.99A 2f16K-5lzlA:
undetectable
2f16L-5lzlA:
undetectable		 2f16K-5lzlA:
20.35
2f16L-5lzlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 160
ALA A 187
ALA A 157
VAL A 124
GLY A 197
 None
 0.99A 2f16Y-5lzlA:
undetectable
2f16Z-5lzlA:
undetectable		 2f16Y-5lzlA:
20.35
2f16Z-5lzlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 5 ASP A  32
ILE A 332
ILE A  28
GLY A  31
 None
 0.95A 3bufA-5lzlA:
undetectable		 3bufA-5lzlA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 5 TYR A 281
ALA A 317
ALA A 200
MET A 176
 None
 1.25A 3d91A-5lzlA:
undetectable		 3d91A-5lzlA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 9 GLY A 250
ALA A 251
ASP A 252
ILE A 253
ILE A 184
 None
 0.91A 3ogpA-5lzlA:
undetectable		 3ogpA-5lzlA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 12 TYR A 262
ILE A  28
GLY A 316
ALA A 315
ALA A 311
 None
 0.99A 3sudB-5lzlA:
undetectable		 3sudB-5lzlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 316
ALA A 317
ASP A 318
LEU A 260
ILE A 312
 None
 0.89A 3ttpA-5lzlA:
undetectable		 3ttpA-5lzlA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 GLY A 316
ALA A 317
ASP A 318
LEU A 260
ILE A 312
 None
 0.89A 3ttpB-5lzlA:
undetectable		 3ttpB-5lzlA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		3 / 3 LYS A  17
ARG A 302
LEU A 336
 None
 1.05A 3v4tE-5lzlA:
undetectable		 3v4tE-5lzlA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		3 / 3 ARG A 302
TYR A  35
ASN A 282
 None
 0.85A 4ffwB-5lzlA:
undetectable		 4ffwB-5lzlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		3 / 3 LYS A 158
LEU A 155
ALA A 157
 None
 0.68A 4ikiA-5lzlA:
undetectable		 4ikiA-5lzlA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 187
LEU A 188
PHE A 193
VAL A 196
ALA A 122
 None
 1.01A 4j14A-5lzlA:
undetectable		 4j14A-5lzlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 217
VAL A 103
ARG A 214
ILE A  79
ALA A 122
 None
 1.10A 4j14A-5lzlA:
undetectable		 4j14A-5lzlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 VAL A 103
TYR A 163
VAL A  39
TYR A  97
LEU A 126
 None
 1.42A 4jq4A-5lzlA:
10.3		 4jq4A-5lzlA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 160
ALA A 187
ALA A 157
VAL A 124
GLY A 197
 None
 1.04A 4qvyK-5lzlA:
undetectable
4qvyL-5lzlA:
undetectable		 4qvyK-5lzlA:
20.06
4qvyL-5lzlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 10 ALA A 160
ALA A 187
ALA A 157
VAL A 124
GLY A 197
 None
 1.04A 4qvyY-5lzlA:
undetectable
4qvyZ-5lzlA:
undetectable		 4qvyY-5lzlA:
20.06
4qvyZ-5lzlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 6 ILE A 198
ALA A 122
VAL A 124
VAL A 196
 None
 0.74A 5eclD-5lzlA:
undetectable		 5eclD-5lzlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 5 ALA A 280
ALA A 259
ILE A 312
LEU A 309
 None
 0.66A 5jncD-5lzlA:
undetectable		 5jncD-5lzlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		4 / 5 ALA A 317
ALA A 280
ILE A 266
LEU A 263
 None
 0.57A 5jncD-5lzlA:
undetectable		 5jncD-5lzlA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Pyrobaculum
calidifontis) 		5 / 12 LEU A 321
PHE A 121
GLN A 180
LEU A 247
ILE A 253
 None
None
ZN  A 402 ( 4.9A)
None
None
 1.03A 5y2tB-5lzlA:
undetectable		 5y2tB-5lzlA:
undetectable