SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 VAL A 162
GLY A 163
LEU A 242
VAL A 179
PHE A 209
 None
 1.43A 1a27A-5m04A:
2.0		 1a27A-5m04A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 6 LEU A 159
ASP A   5
MET A   1
LEU A 227
 None
 1.22A 1errB-5m04A:
undetectable		 1errB-5m04A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 ILE A 214
LEU A 227
GLY A 228
PHE A 231
ALA A 221
 None
 1.23A 1hvyB-5m04A:
undetectable		 1hvyB-5m04A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 5 LEU A 159
ASP A   5
MET A   1
LEU A 227
 None
 1.27A 2qxsA-5m04A:
undetectable		 2qxsA-5m04A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 6 GLY A  36
GLY A 126
GLY A  19
GLY A  37
GLY A  39
 None
 0.99A 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable		 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 6 GLY A  70
GLY A  40
GLY A  80
GLY A  17
GLY A  73
 None
 1.02A 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable		 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 6 GLY A  73
GLY A  39
GLY A  17
GLY A  80
GLY A  70
 None
 0.97A 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable		 3bogA-5m04A:
undetectable
3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  16
GLY A  42
GLY A  14
GLY A  70
 None
 0.56A 3bogC-5m04A:
undetectable		 3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  42
GLY A  70
GLY A  40
GLY A  83
 None
 0.64A 3bogC-5m04A:
undetectable		 3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  70
GLY A  42
GLY A  14
GLY A  83
 None
 0.62A 3bogC-5m04A:
undetectable		 3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  73
GLY A  39
GLY A  17
GLY A  80
 None
 0.65A 3bogC-5m04A:
undetectable		 3bogC-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  16
GLY A  42
GLY A  14
GLY A  70
 None
 0.60A 3bogD-5m04A:
undetectable		 3bogD-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  42
GLY A  70
GLY A  40
GLY A  83
 None
 0.65A 3bogD-5m04A:
undetectable		 3bogD-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  70
GLY A  42
GLY A  14
GLY A  83
 None
 0.64A 3bogD-5m04A:
undetectable		 3bogD-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 GLY A  73
GLY A  39
GLY A  17
GLY A  80
 None
 0.64A 3bogD-5m04A:
undetectable		 3bogD-5m04A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 VAL A 321
CYH A 325
ILE A 332
LEU A 242
VAL A 281
 None
 1.15A 3sp9B-5m04A:
undetectable		 3sp9B-5m04A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 THR A  79
GLY A  37
GLY A 124
HIS A 123
ASP A  35
 None
 1.13A 3tkaA-5m04A:
undetectable		 3tkaA-5m04A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 HIS A   0
GLY A 224
GLY A  -2
SER A  -1
GLY A 216
 None
 1.25A 4blvB-5m04A:
undetectable		 4blvB-5m04A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 11 ILE A 214
LEU A 227
GLY A 228
PHE A 231
ALA A 221
 None
 1.18A 4fogD-5m04A:
undetectable		 4fogD-5m04A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 GLY A  14
ALA A  67
GLY A  42
GLY A  43
GLY A  70
 None
 0.84A 4o33A-5m04A:
undetectable		 4o33A-5m04A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 GLY A  14
ALA A  67
GLY A  42
GLY A  43
GLY A  70
 None
 0.85A 4o3fA-5m04A:
undetectable		 4o3fA-5m04A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 7 GLY A 224
SER A  -1
GLY A  -2
ALA A 222
 None
 0.96A 5e26A-5m04A:
undetectable
5e26B-5m04A:
undetectable		 5e26A-5m04A:
23.33
5e26B-5m04A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 ALA A 274
PRO A 215
LEU A 244
HIS A 243
 None
 1.36A 5eskA-5m04A:
undetectable		 5eskA-5m04A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 6 ASP A  44
GLY A  43
ASP A  85
LYS A 119
 None
 1.22A 5hp1C-5m04A:
undetectable		 5hp1C-5m04A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 9 ILE A  88
PHE A  65
VAL A  96
THR A  94
 None
 0.97A 5lg3I-5m04A:
undetectable		 5lg3I-5m04A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 4 LEU A  53
MET A 108
ILE A  57
LEU A 154
 None
 1.37A 5nfpA-5m04A:
undetectable		 5nfpA-5m04A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 12 ILE A 214
LEU A 227
GLY A 228
PHE A 231
ALA A 221
 None
 1.15A 5x5qB-5m04A:
undetectable		 5x5qB-5m04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		5 / 9 ILE A 214
LEU A 227
GLY A 228
PHE A 231
ALA A 221
 None
 1.23A 5x66C-5m04A:
undetectable		 5x66C-5m04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5m04 GTPASE OBGE/CGTA
(Escherichia
coli) 		4 / 5 GLY A  36
ASP A  77
ARG A  76
GLN A  71
 None
 1.37A 5zrfB-5m04A:
1.9		 5zrfB-5m04A:
19.47