SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 115
ALA A 183
ALA A 187
LEU A 229
HIS A 129
 None
 1.07A 1iiuA-5m09A:
undetectable		 1iiuA-5m09A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 9 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LEU A  73
TYR A  91
 None
 0.73A 1muoA-5m09A:
6.0		 1muoA-5m09A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 6 LYS A  41
LEU A  43
LEU A  85
VAL A  75
 None
 0.93A 1sn5A-5m09A:
undetectable		 1sn5A-5m09A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		3 / 3 TRP A  86
ARG A  78
PHE A  57
 None
 1.26A 1zeaH-5m09A:
undetectable
1zeaL-5m09A:
undetectable		 1zeaH-5m09A:
22.06
1zeaL-5m09A:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  18
GLY A  19
VAL A  26
ALA A  39
MET A  89
TYR A  91
 None
 0.73A 2fumC-5m09A:
25.8		 2fumC-5m09A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  18
VAL A  26
ALA A  39
MET A  89
TYR A  91
VAL A  92
 None
 0.82A 2fumC-5m09A:
25.8		 2fumC-5m09A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 9 ILE A  72
ASP A 126
LEU A 125
GLY A 123
THR A 191
 None
 1.32A 2tsrD-5m09A:
undetectable		 2tsrD-5m09A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 250
PHE A 241
LEU A 225
ALA A 232
 None
 0.82A 3hrdA-5m09A:
undetectable
3hrdB-5m09A:
undetectable		 3hrdA-5m09A:
20.47
3hrdB-5m09A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 139
THR A 191
LEU A 188
HIS A 135
 None
 0.99A 3kp2A-5m09A:
undetectable
3kp2B-5m09A:
undetectable		 3kp2A-5m09A:
18.08
3kp2B-5m09A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 12 ILE A  87
MET A  89
ASP A 137
ASN A 142
ASP A 159
GLY A 161
 None
 0.80A 4an2A-5m09A:
21.9		 4an2A-5m09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 12 LYS A  41
ILE A  87
MET A  89
ASN A 142
ASP A 159
GLY A 161
 None
 0.90A 4an2A-5m09A:
21.9		 4an2A-5m09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		7 / 12 LYS A  41
ILE A  87
MET A  89
ASN A 142
ASP A 159
GLY A 161
MET A  47
 None
 1.04A 4lmnA-5m09A:
21.6		 4lmnA-5m09A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		3 / 3 SER A  44
ASP A 159
ASP A  96
 None
 0.91A 4mwzA-5m09A:
undetectable		 4mwzA-5m09A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 226
LEU A 229
LEU A 233
LEU A 190
ALA A 189
 None
 0.91A 5dqfA-5m09A:
undetectable		 5dqfA-5m09A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  18
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.66A 5h2uC-5m09A:
21.9		 5h2uC-5m09A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.65A 5hieA-5m09A:
20.3		 5hieA-5m09A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.66A 5hieB-5m09A:
5.7		 5hieB-5m09A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  26
ALA A  39
LYS A  41
LEU A  73
ILE A  87
 None
 0.66A 5hieD-5m09A:
15.4		 5hieD-5m09A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  40
LEU A  43
GLY A  24
ILE A 162
ALA A 163
 None
 1.19A 5j7wC-5m09A:
undetectable		 5j7wC-5m09A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 113
MET A 101
LEU A 145
ILE A 155
 None
 0.99A 5mzjA-5m09A:
3.7		 5mzjA-5m09A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 10 LEU A  18
VAL A  26
ALA A  39
MET A  89
TYR A  91
VAL A  92
 None
 0.62A 5n3hA-5m09A:
20.1		 5n3hA-5m09A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 179
ASP A 184
ALA A 183
LEU A 173
ASN A 136
 None
 1.25A 5x6yC-5m09A:
undetectable		 5x6yC-5m09A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		7 / 12 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
 None
 0.78A 5yu9A-5m09A:
16.9		 5yu9A-5m09A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		6 / 12 GLY A  19
VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
 None
 0.78A 5yu9B-5m09A:
21.3		 5yu9B-5m09A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
 None
 0.78A 5yu9C-5m09A:
21.0		 5yu9C-5m09A:
13.28