SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 6 LEU A 143
MET A  96
MET A  49
HIS A 108
 None
 1.26A 1errB-5m0kA:
undetectable		 1errB-5m0kA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 7 GLU A 233
LEU A 234
VAL A 249
LEU A 219
 None
 0.98A 1hk3A-5m0kA:
undetectable		 1hk3A-5m0kA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 ASN A 170
ILE A 198
MET A 187
 None
 0.77A 2h42C-5m0kA:
undetectable		 2h42C-5m0kA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 5 ASP A  39
ARG A  14
ILE A 262
VAL A 295
 None
 1.24A 3eigA-5m0kA:
undetectable		 3eigA-5m0kA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 SER A 122
ASP A 124
ASP A 228
 None
 0.84A 3iv6A-5m0kA:
undetectable		 3iv6A-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 SER A 122
ASP A 124
ASP A 228
 None
 0.86A 3iv6C-5m0kA:
undetectable		 3iv6C-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 TRP A 273
VAL A 264
TRP A 265
 None
 0.91A 3zq8C-5m0kA:
undetectable
3zq8D-5m0kA:
undetectable		 3zq8C-5m0kA:
undetectable
3zq8D-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 7 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 1.01A 4a97A-5m0kA:
undetectable		 4a97A-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 7 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 1.02A 4a97D-5m0kA:
undetectable		 4a97D-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		4 / 6 GLU A  53
PHE A  59
HIS A  81
VAL A  68
 None
 0.99A 4a97I-5m0kA:
undetectable		 4a97I-5m0kA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		5 / 10 ILE A 262
GLY A  17
TYR A  15
ASP A  39
GLY A   6
 None
 1.24A 4bwlC-5m0kA:
9.9		 4bwlC-5m0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		5 / 12 ASN A 278
GLN A 242
LEU A 234
ALA A 291
GLY A 266
 None
 1.19A 4qckA-5m0kA:
undetectable		 4qckA-5m0kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 GLN A 238
SER A 272
ASP A 269
 None
 0.84A 4qwpA-5m0kA:
undetectable
4qwpB-5m0kA:
undetectable		 4qwpA-5m0kA:
24.58
4qwpB-5m0kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 GLN A 242
SER A 272
ASP A 269
 None
 0.84A 4qwpA-5m0kA:
undetectable
4qwpB-5m0kA:
undetectable		 4qwpA-5m0kA:
24.58
4qwpB-5m0kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		5 / 11 PHE A 203
ASP A 171
VAL A 188
TYR A 169
PHE A 222
 None
 1.15A 4xp4A-5m0kA:
undetectable		 4xp4A-5m0kA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		5 / 10 PHE A 203
ASP A 171
VAL A 188
TYR A 169
PHE A 222
 None
 1.18A 4xpbA-5m0kA:
undetectable		 4xpbA-5m0kA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5m0k BETA-XYLANASE
(Cellulomonas
flavigena) 		3 / 3 ARG A 268
PHE A 282
GLY A 286
 None
 0.75A 6fgdA-5m0kA:
undetectable		 6fgdA-5m0kA:
undetectable