SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m0y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 161
PHE A  48
ALA A 130
ILE A 129
ALA A 108
 None
 1.05A 2bxpA-5m0yA:
undetectable		 2bxpA-5m0yA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ILE A  21
ASP A 148
LEU A 157
GLY A 158
PHE A 146
 None
 1.48A 2tsrC-5m0yA:
undetectable		 2tsrC-5m0yA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A 151
ASN B 113
PHE B 157
THR A 149
LEU A 161
 EDO  A 203 ( 4.2A)
CA  B 202 ( 4.7A)
None
None
None
 1.48A 4abzA-5m0yA:
undetectable		 4abzA-5m0yA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A  95
VAL B 153
LEU B 139
ILE B 150
 None
 0.89A 4asdA-5m0yA:
undetectable		 4asdA-5m0yA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ALA A 110
LEU A 109
ALA B 151
ILE B 150
GLY A  91
 None
 1.01A 4r3aB-5m0yA:
undetectable		 4r3aB-5m0yA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		5 / 12 PRO A  79
ILE A 132
TYR A  57
VAL A  56
ASN B 158
 None
None
None
None
EDO  A 203 ( 4.8A)
 1.48A 4xe0A-5m0yA:
undetectable		 4xe0A-5m0yA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 PHE A 146
VAL A  40
ILE A 129
ILE A  45
ILE A 169
 None
 0.98A 5hw8E-5m0yA:
undetectable		 5hw8E-5m0yA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A 146
VAL A  40
ILE A 129
ILE A  45
ILE A 169
 None
 1.02A 5hw8B-5m0yA:
undetectable
5hw8F-5m0yA:
undetectable
5hw8G-5m0yA:
undetectable		 5hw8B-5m0yA:
23.81
5hw8F-5m0yA:
23.81
5hw8G-5m0yA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.98A 6ebzA-5m0yA:
undetectable		 6ebzA-5m0yA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.94A 6ebzB-5m0yA:
undetectable		 6ebzB-5m0yA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.96A 6ebzC-5m0yA:
undetectable		 6ebzC-5m0yA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.92A 6ebzD-5m0yA:
undetectable		 6ebzD-5m0yA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.90A 6gp2A-5m0yA:
undetectable		 6gp2A-5m0yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 11 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
 None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
 0.85A 6gp2B-5m0yA:
undetectable		 6gp2B-5m0yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5m0y IG DOMAIN PROTEIN
GROUP 2 DOMAIN
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL B 102
ILE B  15
TYR B 164
PHE B  19
MET B 141
 None
 1.42A 6j20A-5m0yB:
undetectable		 6j20A-5m0yB:
16.14