SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
0.91A 1fohA-5m10A:
9.4
1fohA-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
0.92A 1fohB-5m10A:
9.4
1fohB-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
0.91A 1fohC-5m10A:
5.1
1fohC-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 GLY A 185
VAL A 183
ILE A 194
TYR A 336
GLY A 187
NAP  A 602 (-3.3A)
None
None
None
NAP  A 602 (-3.3A)
0.91A 1fohD-5m10A:
9.5
1fohD-5m10A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 6 TYR A  92
PRO A 438
GLU A 442
ARG A  66
None
1.46A 1oniA-5m10A:
undetectable
1oniC-5m10A:
undetectable
1oniA-5m10A:
13.12
1oniC-5m10A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 9 VAL A  97
LEU A 102
VAL A  37
GLY A  20
ALA A  16
None
1.21A 1pxxB-5m10A:
undetectable
1pxxB-5m10A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 VAL A  97
LEU A 102
VAL A  37
GLY A  20
ALA A  16
None
1.21A 1pxxD-5m10A:
undetectable
1pxxD-5m10A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 8 PHE A 530
LEU A 414
TRP A 447
THR A 466
None
1.11A 1rmtD-5m10A:
undetectable
1rmtD-5m10A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 4 LYS A  26
LEU A  31
LEU A  33
SER A  34
None
1.30A 1tt6A-5m10A:
undetectable
1tt6A-5m10A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 THR A  47
TYR A  49
ILE A  14
GLY A  15
GLY A  17
FAD  A 601 (-3.2A)
None
FAD  A 601 (-4.6A)
FAD  A 601 (-3.4A)
FAD  A 601 (-3.3A)
0.93A 2fk8A-5m10A:
undetectable
2fk8A-5m10A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 6 THR A 210
THR A 186
ASN A 150
ASP A 383
NAP  A 602 (-3.5A)
NAP  A 602 (-4.3A)
None
None
0.90A 2okcA-5m10A:
3.1
2okcA-5m10A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 7 PRO A 430
GLY A 429
LEU A 394
THR A 141
None
0.88A 2vl2B-5m10A:
undetectable
2vl2B-5m10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 4 SER A 149
GLY A  46
GLY A  41
LYS A  40
None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.2A)
0.97A 2y4nB-5m10A:
undetectable
2y4nB-5m10A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 ILE A 237
ILE A 230
VAL A 227
TYR A  83
ARG A 280
None
GOL  A 609 ( 4.8A)
None
None
None
1.26A 3elzC-5m10A:
undetectable
3elzC-5m10A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
3 / 3 GLU A 256
VAL A 255
CYH A 287
None
1.01A 3fbxA-5m10A:
undetectable
3fbxA-5m10A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
3 / 3 SER A 188
ASP A  59
ASN A 277
NAP  A 602 (-4.1A)
NAP  A 602 ( 2.9A)
None
0.95A 3lsfB-5m10A:
undetectable
3lsfE-5m10A:
undetectable
3lsfB-5m10A:
20.15
3lsfE-5m10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
3 / 3 ASP A  59
ASN A 277
SER A 188
NAP  A 602 ( 2.9A)
None
NAP  A 602 (-4.1A)
0.94A 3lsfB-5m10A:
undetectable
3lsfE-5m10A:
undetectable
3lsfB-5m10A:
20.15
3lsfE-5m10A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 11 VAL A  97
LEU A 102
VAL A  37
GLY A  20
ALA A  16
None
1.21A 3pghB-5m10A:
undetectable
3pghB-5m10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 11 VAL A  44
ALA A  16
GLY A  15
TYR A  67
TYR A  22
None
None
FAD  A 601 (-3.4A)
None
None
1.44A 3qxyB-5m10A:
undetectable
3qxyQ-5m10A:
undetectable
3qxyB-5m10A:
23.30
3qxyQ-5m10A:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 8 PHE A 160
ILE A 154
LEU A 373
PHE A 207
None
0.95A 3rqwI-5m10A:
undetectable
3rqwJ-5m10A:
undetectable
3rqwI-5m10A:
18.97
3rqwJ-5m10A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 5 SER A 440
THR A 435
GLU A 442
ASP A  70
None
1.29A 3tm4A-5m10A:
undetectable
3tm4A-5m10A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 5 SER A 440
THR A 435
GLU A 442
ASP A  70
None
1.28A 3tm4B-5m10A:
3.5
3tm4B-5m10A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 5 GLY A  43
GLY A  42
ASN A 109
GLU A  94
None
TRS  A 604 (-4.0A)
TRS  A 604 (-3.2A)
None
1.15A 4fglC-5m10A:
3.9
4fglC-5m10A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
6 / 12 GLY A  20
GLY A  19
GLY A  17
LEU A 102
VAL A  13
VAL A  35
None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.3A)
None
None
None
1.11A 4htfB-5m10A:
undetectable
4htfB-5m10A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 7 ASN A 423
GLU A 122
GLU A 119
GLU A 464
None
1.01A 4mi4B-5m10A:
undetectable
4mi4C-5m10A:
undetectable
4mi4B-5m10A:
16.20
4mi4C-5m10A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 7 ASN A 423
GLU A 122
GLU A 119
GLU A 464
None
1.00A 4mi4A-5m10A:
undetectable
4mi4C-5m10A:
undetectable
4mi4A-5m10A:
16.20
4mi4C-5m10A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 8 ASN A 423
GLU A 122
GLU A 119
GLU A 464
None
1.05A 4mj8A-5m10A:
undetectable
4mj8C-5m10A:
undetectable
4mj8A-5m10A:
16.45
4mj8C-5m10A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 8 ASN A 423
GLU A 122
GLU A 119
GLU A 464
None
1.02A 4mj8B-5m10A:
undetectable
4mj8C-5m10A:
undetectable
4mj8B-5m10A:
16.45
4mj8C-5m10A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 7 ASN A 423
GLU A 122
GLU A 119
GLU A 464
None
0.72A 4r87I-5m10A:
undetectable
4r87I-5m10A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 6 PRO A 211
ILE A 307
VAL A 215
THR A 191
None
1.15A 4xe5A-5m10A:
undetectable
4xe5A-5m10A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 ALA A 142
VAL A  13
GLY A  46
THR A  47
TYR A  92
None
None
FAD  A 601 (-3.1A)
FAD  A 601 (-3.2A)
None
1.11A 5igiA-5m10A:
undetectable
5igiA-5m10A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 4 GLY A 276
CYH A 332
ARG A 280
GLY A 218
None
1.44A 5inzA-5m10A:
undetectable
5inzC-5m10A:
undetectable
5inzD-5m10A:
undetectable
5inzA-5m10A:
2.74
5inzC-5m10A:
2.74
5inzD-5m10A:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
3 / 3 VAL A 241
GLU A 446
GLU A 442
None
0.90A 5jsdB-5m10A:
undetectable
5jsdC-5m10A:
undetectable
5jsdB-5m10A:
22.68
5jsdC-5m10A:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 5 LEU A 146
ARG A 329
PHE A 434
LEU A 437
TRP A 492
NAP  A 602 ( 4.0A)
NAP  A 602 (-3.0A)
NCA  A 603 ( 3.7A)
FAD  A 601 ( 4.0A)
NAP  A 602 (-4.0A)
0.00A 5m10A-5m10A:
65.7
5m10A-5m10A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 5 LEU A 146
PHE A 507
LEU A 437
TRP A 492
NAP  A 602 ( 4.0A)
None
FAD  A 601 ( 4.0A)
NAP  A 602 (-4.0A)
1.40A 5m10A-5m10A:
65.7
5m10A-5m10A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 GLY A 511
PHE A 248
PHE A 279
ILE A 289
ALA A 290
None
1.02A 5n0tA-5m10A:
undetectable
5n0tA-5m10A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 GLY A 511
PHE A 248
PHE A 279
ILE A 289
ALA A 290
None
1.02A 5n0tB-5m10A:
undetectable
5n0tB-5m10A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 GLY A 511
PHE A 248
PHE A 279
ILE A 289
ALA A 290
None
1.08A 5n0xA-5m10A:
undetectable
5n0xA-5m10A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 10 LEU A 394
GLY A 396
GLY A 399
ARG A 125
ALA A 115
None
1.11A 5o96E-5m10A:
undetectable
5o96F-5m10A:
undetectable
5o96E-5m10A:
17.98
5o96F-5m10A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
3 / 3 GLU A  61
ARG A  82
TYR A  83
None
0.64A 5trqB-5m10A:
undetectable
5trqB-5m10A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 12 VAL A 416
SER A 412
THR A 417
LEU A 437
VAL A 385
None
None
None
FAD  A 601 ( 4.0A)
None
1.37A 6a93B-5m10A:
undetectable
6a93B-5m10A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 6 GLY A 187
THR A 191
GLN A 192
TYR A  53
NAP  A 602 (-3.3A)
None
NAP  A 602 (-3.4A)
None
0.86A 6ag0A-5m10A:
undetectable
6ag0A-5m10A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
4 / 6 GLY A 187
THR A 191
GLN A 192
TYR A  53
NAP  A 602 (-3.3A)
None
NAP  A 602 (-3.4A)
None
0.84A 6ag0C-5m10A:
undetectable
6ag0C-5m10A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 11 TYR A 326
PHE A 269
ALA A 257
THR A 291
LEU A 485
None
1.28A 6efnA-5m10A:
undetectable
6efnA-5m10A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale)
5 / 6 PRO A 216
TRP A 273
ILE A 310
GLY A 335
TYR A 337
GOL  A 607 ( 3.9A)
None
GOL  A 607 (-4.7A)
GOL  A 607 (-3.8A)
GOL  A 607 (-4.4A)
0.24A 6gqiA-5m10A:
55.9
6gqiA-5m10A:
100.00