SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m13'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)
(synthetic
construct) 		6 / 12 VAL B   2
LEU B   4
ALA B  24
VAL B  79
ALA B  98
TYR B 114
 None
 0.75A 3qxtB-5m13B:
22.5		 3qxtB-5m13B:
64.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)
(synthetic
construct) 		5 / 12 VAL B   2
ALA B  24
VAL B  79
ALA B  98
TYR B 114
 None
 0.93A 3qxvD-5m13B:
21.8		 3qxvD-5m13B:
63.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m13 SYNTHETIC NANOBODY
L2_C06 (A-MBP#2)
(synthetic
construct) 		4 / 5 ALA B  61
TYR B  60
GLY B  26
LEU B  72
 EDO  B 202 ( 3.8A)
None
None
None
 1.01A 5eslA-5m13B:
undetectable		 5eslA-5m13B:
14.06