SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 6 ILE C 108
TRP C 110
PHE C  37
GLU C  44
 None
 1.41A 1nsiA-5m15C:
undetectable
1nsiB-5m15C:
undetectable		 1nsiA-5m15C:
14.62
1nsiB-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 6 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.44A 1nsiA-5m15C:
undetectable
1nsiB-5m15C:
undetectable		 1nsiA-5m15C:
14.62
1nsiB-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 6 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.38A 1nsiC-5m15C:
undetectable
1nsiD-5m15C:
undetectable		 1nsiC-5m15C:
14.62
1nsiD-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 ILE C 108
TRP C 110
PHE C  37
GLU C  44
 None
 1.39A 2nsiA-5m15C:
undetectable
2nsiB-5m15C:
undetectable		 2nsiA-5m15C:
14.62
2nsiB-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.38A 2nsiA-5m15C:
undetectable
2nsiB-5m15C:
undetectable		 2nsiA-5m15C:
14.62
2nsiB-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 ILE C 108
TRP C 110
PHE C  37
GLU C  44
 None
 1.34A 3e7gA-5m15C:
undetectable
3e7gB-5m15C:
undetectable		 3e7gA-5m15C:
14.90
3e7gB-5m15C:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.34A 3e7gA-5m15C:
undetectable
3e7gB-5m15C:
undetectable		 3e7gA-5m15C:
14.90
3e7gB-5m15C:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 ILE C 108
TRP C 110
PHE C  37
GLU C  44
 None
 1.36A 3e7gC-5m15C:
undetectable
3e7gD-5m15C:
undetectable		 3e7gC-5m15C:
14.90
3e7gD-5m15C:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 8 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.34A 4cx7A-5m15C:
undetectable
4cx7B-5m15C:
undetectable		 4cx7A-5m15C:
14.62
4cx7B-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 7 PHE C  37
GLU C  44
ILE C 108
TRP C 110
 None
 1.33A 4cx7C-5m15C:
undetectable
4cx7D-5m15C:
undetectable		 4cx7C-5m15C:
14.62
4cx7D-5m15C:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m15 SYNTHETIC NANOBODY
L2_D09, (A-MBP#3)
(synthetic
construct) 		4 / 5 ALA C  61
TYR C  60
GLY C  26
LEU C  72
 None
 0.94A 5eslA-5m15C:
undetectable		 5eslA-5m15C:
13.75