SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		3 / 3 VAL A 385
VAL A 381
TRP A 386
 None
 1.00A 1av2A-5m1bA:
undetectable
1av2B-5m1bA:
undetectable		 1av2A-5m1bA:
3.01
1av2B-5m1bA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		3 / 3 VAL A 381
TRP A 386
VAL A 385
 None
 0.90A 2izqC-5m1bA:
undetectable
2izqD-5m1bA:
undetectable		 2izqC-5m1bA:
3.01
2izqD-5m1bA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 9 ALA A 223
ALA A 220
SER A 268
ALA A 267
CYH A 130
 None
 1.34A 2vh3A-5m1bA:
undetectable		 2vh3A-5m1bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 TRP A 161
GLY A 222
ILE A 316
ASP A 224
LEU A   9
 None
 1.04A 3iv6B-5m1bA:
undetectable		 3iv6B-5m1bA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 TRP A 161
GLY A 222
ILE A 316
ASP A 224
LEU A   9
 None
 1.04A 3iv6D-5m1bA:
undetectable		 3iv6D-5m1bA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		3 / 3 LEU A 365
MET A 451
ASP A 454
 None
 0.80A 3v5wA-5m1bA:
undetectable		 3v5wA-5m1bA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		4 / 5 THR A 160
GLY A 162
VAL A 219
TYR A 317
 None
 1.17A 4grkA-5m1bA:
undetectable		 4grkA-5m1bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
PHE A  67
GLU A 328
GLU A 270
SER A 268
 None
 1.32A 4hvcB-5m1bA:
undetectable		 4hvcB-5m1bA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
PHE A  67
GLU A 328
GLU A 270
SER A 268
 None
 1.33A 4q15B-5m1bA:
undetectable		 4q15B-5m1bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		3 / 3 ASP A 290
GLY A 323
ASP A 327
 None
 0.67A 4xdtA-5m1bA:
undetectable		 4xdtA-5m1bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
PHE A  67
GLU A 328
GLU A 270
SER A 268
 None
 1.36A 4ydqA-5m1bA:
undetectable		 4ydqA-5m1bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
LEU A 229
PHE A  67
ILE A 228
HIS A 318
 None
 1.37A 5dv4A-5m1bA:
undetectable		 5dv4A-5m1bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		4 / 6 PHE A 440
LEU A 438
SER A 442
GLY A 446
 None
 1.13A 5o4yF-5m1bA:
undetectable		 5o4yF-5m1bA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		4 / 7 THR A 369
PHE A 354
LEU A 344
SER A 387
 None
 1.14A 5uxcA-5m1bA:
undetectable		 5uxcA-5m1bA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		4 / 5 ARG A  72
LEU A  16
LEU A  66
PHE A  67
 None
 1.22A 5xdxC-5m1bA:
undetectable
5xdxJ-5m1bA:
undetectable		 5xdxC-5m1bA:
18.97
5xdxJ-5m1bA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
PHE A  67
GLU A 328
GLU A 270
SER A 268
 None
 1.33A 5xiqB-5m1bA:
undetectable		 5xiqB-5m1bA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5m1b 3-OCTAPRENYL-4-HYDRO
XYBENZOATE
CARBOXY-LYASE
(Escherichia
coli) 		5 / 12 LEU A  22
PHE A  67
GLU A 328
GLU A 270
SER A 268
 None
 1.37A 6mn8A-5m1bA:
undetectable		 6mn8A-5m1bA:
22.92