SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 612
VAL A 649
GLY A 648
ALA A 646
LEU A 658
 None
None
C2E  A 701 (-3.6A)
None
None
 1.06A 1e7bA-5m1tA:
undetectable		 1e7bA-5m1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 552
HIS A 550
ASP A 506
LEU A 505
 None
 1.04A 1e7cA-5m1tA:
undetectable		 1e7cA-5m1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 501
GLN A 533
VAL A 498
LEU A 488
LEU A 441
 None
C2E  A 701 (-3.4A)
None
C2E  A 701 (-4.6A)
None
 1.38A 1nhzA-5m1tA:
undetectable		 1nhzA-5m1tA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.89A 2bm9A-5m1tA:
undetectable		 2bm9A-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.99A 2bm9B-5m1tA:
undetectable		 2bm9B-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.96A 2bm9D-5m1tA:
undetectable		 2bm9D-5m1tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.91A 2br4A-5m1tA:
undetectable		 2br4A-5m1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.86A 2br4D-5m1tA:
undetectable		 2br4D-5m1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
GLU A 502
GLY A 501
SER A 542
ALA A 491
 None
 0.96A 2br4F-5m1tA:
undetectable		 2br4F-5m1tA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 473
GLN A 455
PRO A 674
 C2E  A 701 (-2.4A)
C2E  A 701 (-3.0A)
C2E  A 701 (-4.7A)
 1.01A 2qhfA-5m1tA:
undetectable		 2qhfA-5m1tA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 607
LEU A 605
ALA A 566
THR A 565
 None
 0.87A 3b6hA-5m1tA:
undetectable		 3b6hA-5m1tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 607
LEU A 605
ALA A 566
THR A 565
 None
 0.87A 3b6hB-5m1tA:
undetectable		 3b6hB-5m1tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 597
ALA A 570
SER A 573
LEU A 574
LEU A 577
 None
 0.92A 3hs6A-5m1tA:
undetectable		 3hs6A-5m1tA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 564
ASP A 590
LEU A 488
PRO A 489
 None
MG  A 702 (-2.6A)
C2E  A 701 (-4.6A)
None
 1.21A 3jq7B-5m1tA:
undetectable		 3jq7B-5m1tA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 476
VAL A 451
LEU A 450
PHE A 487
ILE A 482
 None
 1.25A 3kk6B-5m1tA:
undetectable		 3kk6B-5m1tA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 539
ILE A 587
PRO A 606
SER A 581
LEU A 529
 None
 1.17A 3nrrA-5m1tA:
undetectable		 3nrrA-5m1tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 591
ASP A 613
ALA A 646
ASP A 590
 MG  A 703 ( 3.3A)
None
None
MG  A 702 (-2.6A)
 1.20A 4mdaA-5m1tA:
undetectable		 4mdaA-5m1tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A 591
ASP A 613
ALA A 646
ASP A 590
 MG  A 703 ( 3.3A)
None
None
MG  A 702 (-2.6A)
 1.21A 4mdbA-5m1tA:
undetectable		 4mdbA-5m1tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 678
GLN A 511
ILE A 525
LEU A 452
 None
 0.91A 4mj8A-5m1tA:
undetectable		 4mj8A-5m1tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 649
GLU A 647
VAL A 645
LYS A 611
 None
MG  A 703 ( 2.2A)
None
MG  A 702 ( 4.4A)
 1.39A 4p6vB-5m1tA:
undetectable
4p6vE-5m1tA:
undetectable		 4p6vB-5m1tA:
21.24
4p6vE-5m1tA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 605
GLY A 586
GLY A 584
PRO A 554
LEU A 557
 None
 1.31A 4x61A-5m1tA:
5.1		 4x61A-5m1tA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5m1t MUCR
PHOSPHODIESTERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 612
ASN A 664
GLY A 637
ALA A 635
LEU A 661
 None
 1.11A 6dwnD-5m1tA:
undetectable		 6dwnD-5m1tA:
15.81