SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 7 ILE A 108
TYR A 137
PHE A 139
PHE A 149
 None
 1.07A 1e71M-5m22A:
undetectable		 1e71M-5m22A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 7 ILE A 108
TYR A 137
PHE A 139
PHE A 149
 None
 1.04A 1e72M-5m22A:
undetectable		 1e72M-5m22A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3;
Sphingomonas
sp.
TTNP3) 		3 / 3 ARG B 109
ASP B 279
ASP A  23
 None
 0.72A 2ejtA-5m22B:
undetectable		 2ejtA-5m22B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 ASP B 302
ASN B  83
ILE A  21
ASP A  24
ARG B 286
 None
 1.46A 2qmjA-5m22B:
undetectable		 2qmjA-5m22B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 11 PHE B  88
ILE B 131
PHE B  42
PHE B  65
VAL B 256
 None
 1.39A 3a9eB-5m22B:
undetectable		 3a9eB-5m22B:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 TYR A  44
ILE A  84
GLY A  82
ALA A 145
LEU A  11
 None
 1.23A 3n8xA-5m22A:
undetectable		 3n8xA-5m22A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 5 ILE B  60
HIS B  58
VAL B  87
HIS B  86
 None
 1.34A 3nneA-5m22B:
undetectable		 3nneA-5m22B:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 5 ILE B  60
HIS B  58
VAL B  87
HIS B  86
 None
 1.32A 3nneB-5m22B:
undetectable		 3nneB-5m22B:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		3 / 3 THR A  65
SER A  66
ARG A 138
 None
 0.56A 3phnA-5m22A:
undetectable		 3phnA-5m22A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 PHE B  88
MET B  99
VAL B  97
ASP B  72
PHE B  84
 None
 1.17A 4c9wA-5m22B:
undetectable		 4c9wA-5m22B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		3 / 3 ARG B 113
TRP B  53
GLY B  56
 None
 0.99A 4e7cA-5m22B:
undetectable		 4e7cA-5m22B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		3 / 3 PRO A 113
TYR A  97
GLY A 109
 None
 0.63A 4g2zA-5m22A:
undetectable		 4g2zA-5m22A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 7 GLU B 264
HIS B 305
VAL B 317
GLU B 319
 FE  B 401 (-2.2A)
FE  B 401 (-3.3A)
None
None
 0.78A 4hvrA-5m22B:
7.9		 4hvrA-5m22B:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 7 HIS B 258
GLU B 264
HIS B 305
GLU B 319
 FE  B 401 (-3.1A)
FE  B 401 (-2.2A)
FE  B 401 (-3.3A)
None
 0.69A 4hvrA-5m22B:
7.9		 4hvrA-5m22B:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 7 GLU B 257
ASP B 276
GLN B 306
ILE B 303
 None
 1.22A 4ii8A-5m22B:
undetectable		 4ii8A-5m22B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 8 VAL B 289
PRO B 300
GLN A 166
ILE A  21
 None
 1.06A 4iilA-5m22B:
undetectable		 4iilA-5m22B:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		3 / 3 ARG B  44
TRP B 135
ILE B  62
 None
 1.06A 4mwxA-5m22B:
undetectable		 4mwxA-5m22B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 4 THR B 290
ARG B 288
GLU A  20
VAL B 274
 None
 1.07A 4odoC-5m22B:
undetectable		 4odoC-5m22B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 8 LEU A 148
MET B 174
LEU B 221
ILE A 121
 None
 0.89A 4ok1A-5m22A:
undetectable		 4ok1A-5m22A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OMW_D_TE4D202_1
(BETA-LACTOGLOBULIN)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 9 LEU B 132
PRO B 142
ASN B 160
ASN B 159
SER B 133
 None
 1.33A 4omwD-5m22B:
undetectable		 4omwD-5m22B:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		4 / 5 ALA B  74
HIS B  86
PRO B 255
PHE B  84
 None
 1.24A 4ze2A-5m22B:
0.9		 4ze2A-5m22B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZUD_A_OLMA1201_1
(CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 9 TYR A  44
PHE A 149
VAL A  77
LEU A  78
ILE A  84
 None
 1.26A 4zudA-5m22A:
0.0		 4zudA-5m22A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 8 GLU A  58
GLY A 154
GLY A 104
VAL A  56
HIS A  73
 None
 1.31A 5f8yB-5m22A:
undetectable		 5f8yB-5m22A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.37A 5jhnB-5m22B:
undetectable		 5jhnB-5m22B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.50A 5jj0B-5m22B:
undetectable		 5jj0B-5m22B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3;
Sphingomonas
sp.
TTNP3) 		4 / 7 VAL A  19
ILE A  21
VAL B 277
ALA B 287
 None
 0.65A 5osrA-5m22A:
undetectable		 5osrA-5m22A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.44A 5t0kA-5m22B:
undetectable		 5t0kA-5m22B:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.41A 5t0mB-5m22B:
undetectable		 5t0mB-5m22B:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.35A 5ttfB-5m22B:
undetectable		 5ttfB-5m22B:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.41A 5tuyB-5m22B:
undetectable		 5tuyB-5m22B:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.33A 5v9iA-5m22B:
undetectable		 5v9iA-5m22B:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.38A 5vscA-5m22B:
undetectable		 5vscA-5m22B:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.35A 5vscB-5m22B:
undetectable		 5vscB-5m22B:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.39A 5vseA-5m22B:
undetectable		 5vseA-5m22B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		5 / 12 GLY B 259
SER B 282
ASN B  83
HIS B  86
GLN B 306
 None
 1.38A 5vseB-5m22B:
undetectable		 5vseB-5m22B:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT
(Sphingomonas
sp.
TTNP3) 		3 / 3 ARG B  71
ARG B 312
ARG B 166
 None
 1.06A 6bplA-5m22B:
undetectable
6bplB-5m22B:
undetectable		 6bplA-5m22B:
14.24
6bplB-5m22B:
14.24