SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		3 / 3 LEU A 101
SER A  97
ASN A 138
 None
 0.76A 1bx4A-5m23A:
undetectable		 1bx4A-5m23A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 1gtfN-5m23A:
undetectable
1gtfO-5m23A:
undetectable		 1gtfN-5m23A:
9.88
1gtfO-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ASN A  34
TYR A  35
LEU A 297
GLN A 295
 None
 1.09A 1qzrB-5m23A:
undetectable		 1qzrB-5m23A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 6 LYS A 207
LEU A 209
SER A 189
SER A 175
 None
 0.97A 1tz8C-5m23A:
undetectable
1tz8D-5m23A:
undetectable		 1tz8C-5m23A:
14.99
1tz8D-5m23A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 CYH A 195
TYR A 191
PRO A 215
SER A 189
 None
 1.38A 1ymxA-5m23A:
undetectable		 1ymxA-5m23A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ILE A 285
PHE A 219
SER A 189
LEU A 230
ALA A 232
 None
 1.34A 3lw5B-5m23A:
undetectable		 3lw5B-5m23A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ASP A 280
ILE A 316
SER A 278
TYR A 284
 None
 0.84A 3pglA-5m23A:
undetectable		 3pglA-5m23A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 7 ALA A 317
PHE A  53
ALA A  74
LEU A 329
 None
 0.94A 4du2A-5m23A:
undetectable		 4du2A-5m23A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 ASN A 100
LEU A 101
SER A  97
ASN A 138
 None
 0.96A 4n09C-5m23A:
undetectable		 4n09C-5m23A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 ASP A  92
SER A  50
VAL A 145
ALA A 308
PHE A 219
 7DC  A 401 ( 4.3A)
None
None
None
None
 1.31A 4nc3A-5m23A:
undetectable		 4nc3A-5m23A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 263
PHE A 219
LEU A 234
PRO A 216
 7DC  A 401 (-3.9A)
None
None
None
 1.44A 4o8zA-5m23A:
undetectable		 4o8zA-5m23A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A 183
GLN A 140
LEU A 143
ILE A 197
PHE A 222
 None
 1.50A 4p6xG-5m23A:
undetectable		 4p6xG-5m23A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 4qvmK-5m23A:
undetectable
4qvmL-5m23A:
undetectable		 4qvmK-5m23A:
22.69
4qvmL-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 4qvmY-5m23A:
undetectable
4qvmZ-5m23A:
undetectable		 4qvmY-5m23A:
22.69
4qvmZ-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.05A 4qvpK-5m23A:
undetectable
4qvpL-5m23A:
undetectable		 4qvpK-5m23A:
22.69
4qvpL-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.05A 4qvpY-5m23A:
undetectable
4qvpZ-5m23A:
undetectable		 4qvpY-5m23A:
22.69
4qvpZ-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.06A 4qw1Y-5m23A:
undetectable
4qw1Z-5m23A:
undetectable		 4qw1Y-5m23A:
22.69
4qw1Z-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 4qw3K-5m23A:
undetectable
4qw3L-5m23A:
undetectable		 4qw3K-5m23A:
22.69
4qw3L-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 10 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 4qw3Y-5m23A:
undetectable
4qw3Z-5m23A:
undetectable		 4qw3Y-5m23A:
22.69
4qw3Z-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 5bxnY-5m23A:
undetectable
5bxnZ-5m23A:
undetectable		 5bxnY-5m23A:
22.69
5bxnZ-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.03A 5d0xK-5m23A:
undetectable
5d0xL-5m23A:
undetectable		 5d0xK-5m23A:
20.84
5d0xL-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 9 ALA A 317
ALA A 308
GLY A  77
GLY A  73
ALA A  74
 None
 1.04A 5d0xY-5m23A:
undetectable
5d0xZ-5m23A:
undetectable		 5d0xY-5m23A:
20.84
5d0xZ-5m23A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5eevL-5m23A:
undetectable
5eevV-5m23A:
undetectable		 5eevL-5m23A:
9.88
5eevV-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5eewL-5m23A:
undetectable
5eewV-5m23A:
undetectable		 5eewL-5m23A:
9.88
5eewV-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5eezL-5m23A:
undetectable
5eezV-5m23A:
undetectable		 5eezL-5m23A:
9.88
5eezV-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5ef1L-5m23A:
undetectable
5ef1V-5m23A:
undetectable		 5ef1L-5m23A:
9.88
5ef1V-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5ef2L-5m23A:
undetectable
5ef2V-5m23A:
undetectable		 5ef2L-5m23A:
9.88
5ef2V-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 5ef3L-5m23A:
undetectable
5ef3V-5m23A:
undetectable		 5ef3L-5m23A:
9.88
5ef3V-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		3 / 3 LYS A 120
TRP A 114
SER A 118
 None
 1.24A 5nwwA-5m23A:
undetectable		 5nwwA-5m23A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5m23 WD REPEAT-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 ASP A  92
SER A  50
VAL A 145
ALA A 308
PHE A 219
 7DC  A 401 ( 4.3A)
None
None
None
None
 1.32A 6dryA-5m23A:
undetectable		 6dryA-5m23A:
19.92