SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 7 PHE A 273
GLU A  76
GLN A  28
VAL A 303
 None
MLR  A 401 ( 4.4A)
MLR  A 401 ( 4.1A)
None
 1.44A 1jqdA-5m28A:
undetectable		 1jqdA-5m28A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 5 PHE A 352
LEU A 171
PHE A 380
SER A 192
 None
 1.15A 1wrkB-5m28A:
undetectable		 1wrkB-5m28A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5m28 MALE1
(Lactobacillus
casei) 		3 / 3 MET A 120
ASN A 105
GLN A 300
 None
 0.89A 1xoqB-5m28A:
undetectable		 1xoqB-5m28A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 ASN A  79
GLU A 112
GLY A 113
THR A 181
 None
 0.94A 1ykiA-5m28A:
undetectable
1ykiB-5m28A:
undetectable		 1ykiA-5m28A:
21.45
1ykiB-5m28A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 THR A 181
ASN A  79
GLU A 112
GLY A 113
 None
 0.91A 1ykiA-5m28A:
undetectable
1ykiB-5m28A:
undetectable		 1ykiA-5m28A:
21.45
1ykiB-5m28A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 ASN A  79
GLU A 112
GLY A 113
THR A 181
 None
 0.92A 1ykiC-5m28A:
undetectable
1ykiD-5m28A:
undetectable		 1ykiC-5m28A:
21.45
1ykiD-5m28A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 THR A 181
ASN A  79
GLU A 112
GLY A 113
 None
 0.92A 1ykiC-5m28A:
undetectable
1ykiD-5m28A:
undetectable		 1ykiC-5m28A:
21.45
1ykiD-5m28A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 PHE A 125
GLU A  76
GLN A  28
TYR A  31
 None
MLR  A 401 ( 4.4A)
MLR  A 401 ( 4.1A)
None
 1.04A 2aoxA-5m28A:
undetectable		 2aoxA-5m28A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 8 PHE A 273
GLU A  76
GLN A  28
TYR A  31
 None
MLR  A 401 ( 4.4A)
MLR  A 401 ( 4.1A)
None
 1.14A 2aoxA-5m28A:
undetectable		 2aoxA-5m28A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 6 THR A 184
TYR A 167
TRP A 353
THR A 181
 None
None
MLR  A 401 (-2.6A)
None
 1.37A 2qmjA-5m28A:
undetectable		 2qmjA-5m28A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5m28 MALE1
(Lactobacillus
casei) 		3 / 3 PRO A 347
PHE A 121
LYS A 345
 None
 1.28A 3bjwG-5m28A:
undetectable		 3bjwG-5m28A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 6 PHE A 267
VAL A 190
THR A 188
PHE A 352
 None
 1.03A 3ltwA-5m28A:
undetectable		 3ltwA-5m28A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 5 PHE A 352
LEU A 171
ILE A 384
VAL A 381
 None
 0.77A 3wrkA-5m28A:
undetectable		 3wrkA-5m28A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5m28 MALE1
(Lactobacillus
casei) 		5 / 10 VAL A  48
LEU A  22
VAL A  20
THR A 289
VAL A  74
 None
 0.95A 4e3hA-5m28A:
undetectable		 4e3hA-5m28A:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UAC_A_ACRA501_1
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5m28 MALE1
(Lactobacillus
casei) 		5 / 12 ALA A  78
ASP A  80
GLN A  81
ASN A 162
TRP A 234
 MLR  A 401 (-3.0A)
MLR  A 401 (-2.1A)
MLR  A 401 (-3.9A)
MLR  A 401 (-3.3A)
MLR  A 401 (-2.8A)
 0.55A 4uacA-5m28A:
46.2		 4uacA-5m28A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 7 ASN A  92
PRO A  93
PHE A 121
PHE A  75
 None
 1.28A 4v32A-5m28A:
undetectable		 4v32A-5m28A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 7 TYR A 252
VAL A 169
ILE A 360
LEU A 156
 None
 0.97A 4xo7B-5m28A:
undetectable		 4xo7B-5m28A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 4 VAL A  64
ALA A  60
ASN A  59
GLN A  81
 None
None
None
MLR  A 401 (-3.9A)
 1.45A 4zgfA-5m28A:
undetectable		 4zgfA-5m28A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 6 ASP A  73
ASP A  45
ASN A  15
ASN A 283
 None
None
None
CL  A 402 (-4.2A)
 1.17A 5l6eA-5m28A:
undetectable		 5l6eA-5m28A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5m28 MALE1
(Lactobacillus
casei) 		5 / 12 GLY A 269
VAL A 312
ALA A 129
TYR A 252
ALA A 266
 None
 1.11A 5n0oB-5m28A:
undetectable		 5n0oB-5m28A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5m28 MALE1
(Lactobacillus
casei) 		5 / 12 ALA A 356
THR A 161
LEU A 177
ASN A 354
PHE A 352
 None
 0.95A 5ybbA-5m28A:
undetectable		 5ybbA-5m28A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5m28 MALE1
(Lactobacillus
casei) 		4 / 6 TYR A 164
GLN A  81
VAL A  77
ALA A 266
 MLR  A 401 (-2.8A)
MLR  A 401 (-3.9A)
None
None
 1.23A 6djzB-5m28A:
undetectable		 6djzB-5m28A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5m28 MALE1
(Lactobacillus
casei) 		5 / 11 ASP A 189
VAL A 190
SER A 192
LEU A 177
ALA A 198
 None
 1.27A 6dryA-5m28A:
undetectable		 6dryA-5m28A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 5m28 MALE1
(Lactobacillus
casei) 		5 / 12 LEU A 301
PRO A 311
THR A 131
SER A 236
GLY A 232
 None
 1.21A 6mn8A-5m28A:
undetectable		 6mn8A-5m28A:
22.71