SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		3 / 3 VAL A  53
VAL A 218
TRP A  55
 None
 0.89A 1bdwA-5m2dA:
undetectable
1bdwB-5m2dA:
undetectable		 1bdwA-5m2dA:
6.83
1bdwB-5m2dA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		3 / 3 TRP A 151
TYR A 185
LEU A 124
 None
 1.02A 1kxhA-5m2dA:
undetectable		 1kxhA-5m2dA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.87A 1qzfA-5m2dA:
undetectable		 1qzfA-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.88A 1qzfB-5m2dA:
undetectable		 1qzfB-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.88A 1qzfC-5m2dA:
undetectable		 1qzfC-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.88A 1qzfD-5m2dA:
undetectable		 1qzfD-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.87A 1qzfE-5m2dA:
undetectable		 1qzfE-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		3 / 3 PHE A 108
TYR A  67
TYR A  69
 None
 0.92A 1x70B-5m2dA:
undetectable		 1x70B-5m2dA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 1.03A 2oipA-5m2dA:
undetectable		 2oipA-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.94A 2oipD-5m2dA:
undetectable		 2oipD-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.81A 2oipE-5m2dA:
undetectable		 2oipE-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		4 / 8 VAL A  49
GLY A  20
HIS A  16
TYR A  15
 None
 0.99A 3af0A-5m2dA:
undetectable		 3af0A-5m2dA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 1.10A 3hj3A-5m2dA:
undetectable		 3hj3A-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 1.01A 3hj3B-5m2dA:
undetectable		 3hj3B-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 ALA A 104
LEU A 124
THR A  88
ILE A  86
LEU A 199
 None
 0.81A 3hj3D-5m2dA:
undetectable		 3hj3D-5m2dA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		4 / 8 GLU A 207
GLU A 123
ILE A 126
LEU A 107
 None
 0.93A 4mj8A-5m2dA:
undetectable		 4mj8A-5m2dA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		5 / 12 PHE A 192
ALA A 194
THR A 177
LEU A 199
LEU A 124
 None
 1.34A 4qztC-5m2dA:
undetectable		 4qztC-5m2dA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5m2d ENDOGLUCANASE-LIKE
PROTEIN
(Acremonium
chrysogenum) 		4 / 7 LEU A  79
SER A  82
ILE A  83
VAL A 225
 None
 1.23A 4tvtA-5m2dA:
undetectable		 4tvtA-5m2dA:
21.65