SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5m2o GROUP I DOCKERIN
(Ruminococcus
flavefaciens) 		5 / 10 PRO B  93
VAL B  67
ARG B  62
VAL B  95
GLY B  29
 None
 1.45A 13gsA-5m2oB:
undetectable		 13gsA-5m2oB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5m2o GROUP I DOCKERIN
(Ruminococcus
flavefaciens) 		5 / 9 PRO B  93
VAL B  67
ARG B  62
VAL B  95
GLY B  29
 None
 1.45A 13gsB-5m2oB:
undetectable		 13gsB-5m2oB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		4 / 7 ILE B  39
PHE A  76
PHE A  95
PHE A 114
 None
 0.98A 1e71M-5m2oB:
undetectable		 1e71M-5m2oB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		4 / 7 ILE B  39
PHE A  76
PHE A  95
PHE A 114
 None
 0.96A 1e72M-5m2oB:
undetectable		 1e72M-5m2oB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 VAL A  99
ASN A 100
VAL A  45
ILE A 138
 None
 1.01A 1z2bC-5m2oA:
undetectable		 1z2bC-5m2oA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		4 / 5 SER A  37
VAL A 120
SER B  40
VAL B  43
 None
 1.39A 2j9cA-5m2oA:
undetectable
2j9cB-5m2oA:
undetectable
2j9cC-5m2oA:
undetectable		 2j9cA-5m2oA:
22.58
2j9cB-5m2oA:
22.58
2j9cC-5m2oA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 9 ALA B  31
ASP B  41
ILE B  82
VAL B  43
ASN A 124
 None
CA  B 201 (-2.2A)
None
None
None
 1.41A 2x08A-5m2oB:
undetectable		 2x08A-5m2oB:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		4 / 8 GLN A 128
GLN B  47
ASP A 125
SER A 127
 None
 1.23A 2xz5C-5m2oA:
undetectable
2xz5D-5m2oA:
undetectable		 2xz5C-5m2oA:
18.55
2xz5D-5m2oA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5m2o GROUP I DOCKERIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 6 SER B  40
ALA A  38
HIS A 121
ASP A  40
 None
 1.19A 3aruA-5m2oB:
undetectable		 3aruA-5m2oB:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 PHE A  10
VAL A  27
ALA A  93
VAL A   8
ILE A  54
 None
 1.04A 3czhA-5m2oA:
undetectable		 3czhA-5m2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 PHE A  10
VAL A  27
ALA A  93
VAL A   8
ILE A  54
 None
 1.07A 3dl9A-5m2oA:
undetectable		 3dl9A-5m2oA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5m2o GROUP I DOCKERIN
(Ruminococcus
flavefaciens) 		4 / 5 PRO B  94
THR B  75
VAL B  74
GLY B  73
 None
CA  B 202 ( 4.8A)
None
CA  B 202 (-4.5A)
 1.07A 3elzA-5m2oB:
undetectable		 3elzA-5m2oB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5m2o GROUP I DOCKERIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 8 HIS A 121
LEU B  92
ASP B  41
ASP B  30
 None
None
CA  B 201 (-2.2A)
CA  B 201 (-3.2A)
 0.97A 3n2oC-5m2oA:
undetectable
3n2oD-5m2oA:
undetectable		 3n2oC-5m2oA:
12.15
3n2oD-5m2oA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5m2o GROUP I DOCKERIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  72
ASP B  78
ASP B  66
ARG B  62
 CA  B 202 (-2.9A)
CA  B 202 (-2.3A)
CA  B 202 (-3.0A)
None
 1.25A 3naiA-5m2oB:
undetectable		 3naiA-5m2oB:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 11 THR A  63
VAL A  65
VAL A 120
PHE A  12
PHE A  10
 None
 1.37A 3tbgA-5m2oA:
undetectable		 3tbgA-5m2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2o GROUP I DOCKERIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 201 (-2.2A)
None
None
CA  B 201 (-3.2A)
 1.45A 3w9tB-5m2oB:
undetectable		 3w9tB-5m2oB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2o GROUP I DOCKERIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 201 (-2.2A)
None
None
CA  B 201 (-3.2A)
 1.45A 3w9tC-5m2oB:
undetectable		 3w9tC-5m2oB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2o GROUP I DOCKERIN
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 201 (-2.2A)
None
None
CA  B 201 (-3.2A)
 1.45A 3w9tD-5m2oB:
undetectable		 3w9tD-5m2oB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5m2o GROUP I DOCKERIN
(Ruminococcus
flavefaciens) 		4 / 6 ASP B  30
ASN B  64
ALA B  65
ASP B  38
 CA  B 201 (-3.2A)
None
None
None
 1.10A 4mdbA-5m2oB:
undetectable		 4mdbA-5m2oB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
GROUP I DOCKERIN
(Ruminococcus
flavefaciens;
Ruminococcus
flavefaciens) 		5 / 12 TYR B  85
GLY B  29
ASP B  78
ILE B  36
GLY A 126
 None
None
CA  B 202 (-2.3A)
None
None
 0.95A 4obwB-5m2oB:
undetectable		 4obwB-5m2oB:
20.00