SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m2s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 ASP A  47
VAL A  99
ILE A 138
GLY A 136
ILE A  52
 GOL  A 203 (-3.7A)
None
None
None
None
 0.85A 2bpxB-5m2sA:
undetectable		 2bpxB-5m2sA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 6 SER B  40
ALA A  39
HIS A 121
ASP A  41
 None
 1.18A 3aruA-5m2sB:
undetectable		 3aruA-5m2sB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.15A 3eeyA-5m2sB:
undetectable		 3eeyA-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.17A 3eeyB-5m2sB:
undetectable		 3eeyB-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.15A 3eeyC-5m2sB:
undetectable		 3eeyC-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.15A 3eeyD-5m2sB:
undetectable		 3eeyD-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.16A 3eeyE-5m2sB:
undetectable		 3eeyE-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.17A 3eeyH-5m2sB:
undetectable		 3eeyH-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.16A 3eeyI-5m2sB:
undetectable		 3eeyI-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
(Ruminococcus
flavefaciens) 		5 / 12 THR B 102
ASN B  72
ASP B  74
GLY B  99
ASN B  78
 None
None
CA  B 201 (-3.1A)
None
None
 1.14A 3eeyJ-5m2sB:
undetectable		 3eeyJ-5m2sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 8 HIS A 121
LEU B 101
ASP B  41
ASP B  30
 None
None
CA  B 202 (-2.1A)
CA  B 202 (-3.2A)
 1.05A 3n2oC-5m2sA:
undetectable
3n2oD-5m2sA:
undetectable		 3n2oC-5m2sA:
12.46
3n2oD-5m2sA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 12 LEU A  97
PHE A  11
VAL A  94
ALA A  66
PHE A  77
 None
 1.50A 3nhxA-5m2sA:
undetectable		 3nhxA-5m2sA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 202 (-2.1A)
None
None
CA  B 202 (-3.2A)
 1.48A 3w9tB-5m2sB:
undetectable		 3w9tB-5m2sB:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 202 (-2.1A)
None
None
CA  B 202 (-3.2A)
 1.48A 3w9tC-5m2sB:
undetectable		 3w9tC-5m2sB:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5m2s DOC8: TYPE I
DOCKERIN REPEAT
DOMAIN FROM FAMILY 9
GLYCOSIDE HYDROLASE
WP_009982745[RUMINOC
OCCUS FLAVEFACIENS]
PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		4 / 5 ASP B  41
SER B  40
GLY A 126
ASP B  30
 CA  B 202 (-2.1A)
None
None
CA  B 202 (-3.2A)
 1.48A 3w9tD-5m2sB:
undetectable		 3w9tD-5m2sB:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 11 ASP A  47
VAL A  99
ILE A 138
GLY A 136
ILE A  52
 GOL  A 203 (-3.7A)
None
None
None
None
 1.01A 4njvC-5m2sA:
undetectable		 4njvC-5m2sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 9 VAL A  42
GLY A 136
VAL A 112
ASP A  12
GLY A  14
 None
 1.22A 5zniA-5m2sA:
undetectable		 5zniA-5m2sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 5m2s PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN
(Ruminococcus
flavefaciens) 		5 / 10 ASP A  47
VAL A  99
ILE A 138
GLY A 136
ILE A  52
 GOL  A 203 (-3.7A)
None
None
None
None
 1.01A 6dj2A-5m2sA:
undetectable		 6dj2A-5m2sA:
17.12