SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 11 LEU J 104
LEU J 102
MET J  35
ILE J 183
LEU J 115
 None
 1.24A 1g50A-5m32J:
undetectable		 1g50A-5m32J:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5m32 26S PROTEASE
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 6 ILE d 351
LYS d 237
ALA d 240
VAL d 222
 None
 0.84A 1hk1A-5m32d:
undetectable		 1hk1A-5m32d:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens) 		5 / 9 ILE C  40
ARG C 212
LEU C 220
ILE C 188
ASP C 184
 None
 1.40A 1nb9A-5m32C:
undetectable		 1nb9A-5m32C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.04A 1pxxC-5m32J:
undetectable		 1pxxC-5m32J:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 ILE J 183
ALA J 156
GLY J   6
LEU J 103
LEU J 115
 None
 1.10A 1rjdA-5m32J:
undetectable		 1rjdA-5m32J:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 ILE J 183
ALA J 156
GLY J   6
LEU J 103
LEU J 115
 None
 1.10A 1rjdB-5m32J:
undetectable		 1rjdB-5m32J:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		4 / 7 TYR J 147
LEU J 115
TYR J  12
ILE J   5
 None
 1.12A 1tuvA-5m32J:
undetectable		 1tuvA-5m32J:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 10 LEU J 160
ALA J 156
ILE J   7
VAL J 182
LEU J  43
 None
 1.14A 1xp0A-5m32J:
undetectable		 1xp0A-5m32J:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5m32 26S PROTEASE
REGULATORY SUBUNIT 4
(Homo
sapiens) 		3 / 3 ARG d 307
GLU d 304
GLN d 306
 None
 0.85A 2p16A-5m32d:
undetectable		 2p16A-5m32d:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 ALA J  22
GLU J   2
GLY J  48
HIS J  99
THR J  53
 None
 1.42A 2xffA-5m32J:
undetectable		 2xffA-5m32J:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 ASN J 101
VAL J  47
TYR J   3
PHE J 137
TYR J 117
 None
 1.24A 3megA-5m32J:
undetectable		 3megA-5m32J:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.02A 3n8xB-5m32J:
undetectable		 3n8xB-5m32J:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		4 / 6 LEU J 104
ALA J 122
LEU J  88
THR J  84
 None
 1.10A 3rozA-5m32J:
undetectable		 3rozA-5m32J:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.06A 4coxC-5m32J:
undetectable		 4coxC-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens) 		5 / 12 LEU C 144
ALA C 209
ILE C 133
ASP C 214
GLY C 135
 None
 1.15A 4hfpB-5m32C:
undetectable		 4hfpB-5m32C:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J 104
LEU J 102
MET J  35
ILE J 183
LEU J 115
 None
 1.21A 4j24B-5m32J:
undetectable		 4j24B-5m32J:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens) 		3 / 3 TYR C 110
ARG C 117
SER C 113
 None
 1.03A 4lf7I-5m32C:
undetectable
4lf7J-5m32C:
undetectable		 4lf7I-5m32C:
22.55
4lf7J-5m32C:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens) 		3 / 3 TYR C 110
ARG C 117
SER C 113
 None
 1.03A 4lf8I-5m32C:
undetectable
4lf8J-5m32C:
undetectable		 4lf8I-5m32C:
22.55
4lf8J-5m32C:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.93A 4otyA-5m32J:
undetectable		 4otyA-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.96A 4otyB-5m32J:
undetectable		 4otyB-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5m32 26S PROTEASE
REGULATORY SUBUNIT 4
(Homo
sapiens) 		5 / 12 ILE d 342
ALA d 340
MET d 309
ILE d 284
ILE d 347
 None
 1.13A 4ptjA-5m32d:
undetectable		 4ptjA-5m32d:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.87A 4rrwD-5m32J:
undetectable		 4rrwD-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.87A 4rrzD-5m32J:
undetectable		 4rrzD-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 9 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.04A 4rs0A-5m32J:
undetectable		 4rs0A-5m32J:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		4 / 7 ALA J  79
THR J  78
TYR J 116
GLU J 111
 None
 1.18A 5ecnA-5m32J:
undetectable		 5ecnA-5m32J:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.94A 5ikqA-5m32J:
undetectable		 5ikqA-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 0.96A 5ikqB-5m32J:
undetectable		 5ikqB-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.00A 5ikrB-5m32J:
undetectable		 5ikrB-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		3 / 3 GLY J 112
GLN J   8
LYS J 185
 None
 0.99A 5imsB-5m32J:
undetectable		 5imsB-5m32J:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.08A 5jw1B-5m32J:
undetectable		 5jw1B-5m32J:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		5 / 12 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.02A 5kirA-5m32J:
undetectable		 5kirA-5m32J:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5m32 26S PROTEASE
REGULATORY SUBUNIT 4
(Homo
sapiens) 		4 / 5 ARG d 307
MET d 309
THR d 308
LEU d 312
 None
 1.39A 5z86J-5m32d:
undetectable		 5z86J-5m32d:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens) 		4 / 6 SER J  39
ALA J  80
THR J  84
ALA J  57
 None
 1.16A 6ma6A-5m32J:
undetectable		 6ma6A-5m32J:
18.44