SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 830
ALA A 944
PHE A 937
LEU A 898
ALA A 829
 None
 1.06A 1ao8A-5m3cA:
undetectable		 1ao8A-5m3cA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 863
LEU A 816
GLY A 862
ASN A 854
THR A 814
 GTP  A1304 (-3.6A)
None
GTP  A1304 (-3.4A)
GTP  A1304 (-2.9A)
None
 1.11A 1likA-5m3cA:
undetectable		 1likA-5m3cA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A1203
ARG A1177
ALA A1173
ILE A1158
 None
 1.10A 1oniA-5m3cA:
undetectable
1oniB-5m3cA:
undetectable		 1oniA-5m3cA:
undetectable
1oniB-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 6 PHE A1203
ARG A1177
ALA A1173
ILE A1158
 None
 1.22A 1oniH-5m3cA:
undetectable
1oniI-5m3cA:
undetectable		 1oniH-5m3cA:
undetectable
1oniI-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 7 ILE A1158
PHE A1203
ARG A1177
ALA A1173
 None
 1.05A 1oniG-5m3cA:
undetectable
1oniI-5m3cA:
undetectable		 1oniG-5m3cA:
undetectable
1oniI-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A1080
PRO A1100
ILE A1086
LEU A1085
 None
 1.13A 1ya4B-5m3cA:
undetectable		 1ya4B-5m3cA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A1080
PRO A1100
ILE A1086
LEU A1085
 None
 1.07A 1ya4C-5m3cA:
undetectable		 1ya4C-5m3cA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A1077
LEU A1080
CYH A1055
LEU A1092
ALA A1078
 None
 1.09A 3av6A-5m3cA:
undetectable		 3av6A-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 MET A1113
GLY A1139
LEU A1182
MET A1186
LEU A1188
 None
 1.27A 3h52D-5m3cA:
undetectable		 3h52D-5m3cA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A1130
LEU A1103
LEU A1133
LEU A1089
LEU A1129
 None
 1.24A 3ndvA-5m3cA:
undetectable
3ndvB-5m3cA:
undetectable		 3ndvA-5m3cA:
14.29
3ndvB-5m3cA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1105
LEU A1089
ILE A1086
LEU A1085
PRO A1152
 None
 0.95A 4odrA-5m3cA:
undetectable
4odrB-5m3cA:
undetectable		 4odrA-5m3cA:
20.75
4odrB-5m3cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1135
MET A1113
ALA A1119
LEU A1123
PHE A1138
 None
 1.21A 4zo1X-5m3cA:
undetectable		 4zo1X-5m3cA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		4 / 5 ALA A1014
TYR A1000
GLY A1041
LEU A 996
 None
 0.97A 5eslA-5m3cA:
undetectable		 5eslA-5m3cA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1107
PHE A1111
LEU A1075
VAL A1122
ALA A1121
 None
 1.25A 5km9B-5m3cA:
undetectable		 5km9B-5m3cA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A1053
GLU A1052
TRP A1049
 None
 1.08A 5odiD-5m3cA:
undetectable		 5odiD-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A1053
GLU A1052
TRP A1049
 None
 1.15A 5odqD-5m3cA:
undetectable		 5odqD-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5m3c DIGUANYLATE CYCLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A1053
GLU A1052
TRP A1049
 None
 1.07A 5odrD-5m3cA:
undetectable		 5odrD-5m3cA:
undetectable