SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		5 / 11 ILE B 134
ALA B 132
LEU B  85
PRO B  82
ILE B 137
 None
 1.17A 1dg5A-5m3lB:
undetectable		 1dg5A-5m3lB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5m3l EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		4 / 4 ALA C 133
GLN C  18
TYR C 131
LEU C 140
 None
 1.47A 1e6wC-5m3lC:
undetectable		 1e6wC-5m3lC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5m3l HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 12 LEU D  77
LEU D  74
VAL D  73
SER D  70
HIS D 101
 None
None
HEM  D 201 ( 4.8A)
None
HEM  D 201 (-3.5A)
 1.05A 3m7rA-5m3lD:
undetectable		 3m7rA-5m3lD:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5m3l HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 10 HIS D 120
ASP D  41
HIS D 117
PRO D  47
HIS D  46
 None
 1.33A 4bz6A-5m3lD:
undetectable		 4bz6A-5m3lD:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5m3l HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 12 HIS D 120
ASP D  41
HIS D 117
PRO D  47
HIS D  46
 None
 1.27A 4bz6C-5m3lD:
undetectable		 4bz6C-5m3lD:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5m3l HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 10 HIS D 120
ASP D  41
HIS D 117
PRO D  47
HIS D  46
 None
 1.31A 4bz6D-5m3lD:
undetectable		 4bz6D-5m3lD:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5m3l EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		4 / 9 PHE C 113
HIS C 102
PHE C  54
ILE C  47
 HEM  C 201 (-3.9A)
HEM  C 201 (-3.6A)
HEM  C 201 ( 4.3A)
None
 1.29A 4jvlA-5m3lC:
undetectable		 4jvlA-5m3lC:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		5 / 12 GLU B   8
LEU B 114
VAL B 117
ILE B 113
LEU B  69
 None
 1.45A 4k38B-5m3lB:
undetectable		 4k38B-5m3lB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		5 / 12 GLU B   8
LEU B 114
VAL B 117
ILE B 113
LEU B  69
 None
 1.37A 4k39A-5m3lB:
undetectable		 4k39A-5m3lB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 10 LEU C  22
LEU C  78
LEU C 120
LEU C 124
LEU D  15
 None
HEM  C 201 ( 4.9A)
None
None
None
 1.02A 4odoA-5m3lC:
undetectable		 4odoA-5m3lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 10 LEU C  22
LEU C  78
LEU C 120
LEU C 124
LEU D  15
 None
HEM  C 201 ( 4.9A)
None
None
None
 1.00A 4odoB-5m3lC:
undetectable		 4odoB-5m3lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 10 LEU C  22
LEU C  78
LEU C 120
LEU C 124
LEU D  15
 None
HEM  C 201 ( 4.9A)
None
None
None
 1.04A 4odoC-5m3lC:
undetectable		 4odoC-5m3lC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5m3l EXTRACELLULAR
GLOBIN-2
EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		3 / 3 GLN B  95
HIS B  91
ARG C  73
 HEM  B 201 ( 4.5A)
HEM  C 201 (-3.5A)
HEM  C 201 (-3.7A)
 1.00A 4qyqB-5m3lB:
undetectable		 4qyqB-5m3lB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 5m3l EXTRACELLULAR
GLOBIN-3
HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris;
Lumbricus
terrestris) 		4 / 6 GLU D  13
THR D  12
LEU C  38
GLN C 126
 None
 1.24A 4qztA-5m3lD:
undetectable		 4qztA-5m3lD:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5m3l EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		5 / 12 PHE C 116
ILE C  74
VAL C  15
LEU C  78
LEU C 144
 HEM  C 201 (-4.0A)
HEM  C 201 (-4.5A)
None
HEM  C 201 ( 4.9A)
None
 1.10A 4qzuA-5m3lC:
undetectable		 4qzuA-5m3lC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5m3l EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		5 / 12 PHE C 116
ILE C  74
VAL C  15
LEU C  78
LEU C 144
 HEM  C 201 (-4.0A)
HEM  C 201 (-4.5A)
None
HEM  C 201 ( 4.9A)
None
 1.02A 4qzuC-5m3lC:
undetectable		 4qzuC-5m3lC:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5m3l EXTRACELLULAR
GLOBIN-3
(Lumbricus
terrestris) 		4 / 6 LEU C  95
CYH C 139
CYH C   7
LEU C  85
 None
 1.24A 5hrqB-5m3lC:
undetectable
5hrqI-5m3lC:
undetectable
5hrqJ-5m3lC:
undetectable		 5hrqB-5m3lC:
12.61
5hrqI-5m3lC:
8.55
5hrqJ-5m3lC:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5m3l HEMOGLOBIN CHAIN D1
(Lumbricus
terrestris) 		5 / 12 PHE D  53
VAL D  73
TRP D  39
ILE D  49
LEU D 106
 HEM  D 201 (-4.3A)
HEM  D 201 ( 4.8A)
None
None
None
 1.12A 5im2A-5m3lD:
undetectable		 5im2A-5m3lD:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		4 / 7 THR B  37
PHE B  38
VAL B  41
ILE B 101
 None
 1.15A 5vkqA-5m3lB:
undetectable
5vkqB-5m3lB:
undetectable		 5vkqA-5m3lB:
5.85
5vkqB-5m3lB:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		4 / 8 THR B  37
PHE B  38
VAL B  41
ILE B 101
 None
 1.14A 5vkqB-5m3lB:
undetectable
5vkqC-5m3lB:
undetectable		 5vkqB-5m3lB:
5.85
5vkqC-5m3lB:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5m3l EXTRACELLULAR
GLOBIN-2
(Lumbricus
terrestris) 		4 / 7 THR B  37
PHE B  38
VAL B  41
ILE B 101
 None
 1.12A 5vkqC-5m3lB:
undetectable
5vkqD-5m3lB:
undetectable		 5vkqC-5m3lB:
5.85
5vkqD-5m3lB:
5.85