SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 12 LEU A 203
LEU A  42
ILE A 218
LEU A  25
VAL A  13
 None
 1.03A 1hrkA-5m3qA:
undetectable		 1hrkA-5m3qA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 7 LEU A 176
LEU A 181
MET A 152
GLN A 140
 None
 1.09A 1kt3A-5m3qA:
undetectable		 1kt3A-5m3qA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 182
ALA A 183
HIS A 162
 None
 0.62A 1q23G-5m3qA:
undetectable		 1q23G-5m3qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		3 / 3 VAL A 182
ALA A 183
HIS A 162
 None
 0.66A 1q23J-5m3qA:
undetectable		 1q23J-5m3qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 12 ILE A 218
GLY A 158
SER A 155
ALA A 204
VAL A 205
 None
 0.94A 2oc8A-5m3qA:
undetectable		 2oc8A-5m3qA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 12 LEU A 203
LEU A  42
ILE A 218
LEU A  25
VAL A  13
 None
 1.01A 2po7A-5m3qA:
undetectable		 2po7A-5m3qA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 12 GLY A  60
GLY A 195
GLY A 196
LEU A 104
ILE A  53
 GOL  A 304 (-4.3A)
GOL  A 304 (-3.9A)
None
None
None
 0.83A 3douA-5m3qA:
undetectable		 3douA-5m3qA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 7 GLY A 159
VAL A 221
ILE A 193
GLN A 170
 None
 0.84A 3fi0P-5m3qA:
undetectable		 3fi0P-5m3qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 12 VAL A 135
ALA A 115
LEU A  25
ILE A  53
LEU A  71
 None
 1.01A 3gcsA-5m3qA:
undetectable		 3gcsA-5m3qA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 6 VAL A 199
VAL A 109
ILE A 193
ARG A 223
 None
 1.13A 3mssA-5m3qA:
undetectable		 3mssA-5m3qA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 6 VAL A 199
VAL A 109
ILE A 193
ARG A 223
 None
 1.15A 3mssC-5m3qA:
undetectable		 3mssC-5m3qA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 9 ARG A   4
ASN A  11
ALA A   5
LEU A 203
VAL A  13
 None
 1.32A 3o01A-5m3qA:
undetectable
3o01B-5m3qA:
undetectable		 3o01A-5m3qA:
23.08
3o01B-5m3qA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 4 LEU A  70
GLY A  69
GLY A  65
THR A  20
 None
 0.69A 3si7A-5m3qA:
undetectable		 3si7A-5m3qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 5 LEU A  70
GLY A  69
GLY A  65
THR A  20
 None
 0.68A 3si7C-5m3qA:
undetectable
3si7D-5m3qA:
undetectable		 3si7C-5m3qA:
20.06
3si7D-5m3qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 11 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.97A 4c5lA-5m3qA:
undetectable		 4c5lA-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 9 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.91A 4c5lB-5m3qA:
undetectable		 4c5lB-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 10 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.88A 4c5lC-5m3qA:
undetectable		 4c5lC-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 10 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.90A 4c5lD-5m3qA:
undetectable		 4c5lD-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 10 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.86A 4c5nB-5m3qA:
undetectable		 4c5nB-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 8 GLY A  69
GLY A  65
VAL A 135
CYH A 110
 None
 0.78A 4c5nC-5m3qA:
undetectable		 4c5nC-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		5 / 10 GLY A  69
ALA A  64
GLY A  65
VAL A 135
CYH A 110
 None
 0.92A 4c5nD-5m3qA:
undetectable		 4c5nD-5m3qA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 6 LEU A  25
ILE A  92
THR A  20
GLY A  65
 None
 0.93A 4l39A-5m3qA:
undetectable		 4l39A-5m3qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 7 LEU A  25
ILE A  92
THR A  20
GLY A  65
 None
 0.96A 4l39B-5m3qA:
undetectable		 4l39B-5m3qA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 5 ILE A  97
ILE A 117
HIS A 118
VAL A 107
 None
 0.82A 5jmnA-5m3qA:
undetectable		 5jmnA-5m3qA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		3 / 3 THR A 141
PRO A 119
ASP A 120
 None
 0.77A 5l8dB-5m3qA:
undetectable		 5l8dB-5m3qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		3 / 3 THR A 141
PRO A 119
ASP A 120
 None
 0.77A 5mwuB-5m3qA:
undetectable		 5mwuB-5m3qA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
(Chaetomium
thermophilum) 		4 / 7 PHE A  34
PHE A  16
GLY A  14
GLY A  60
 None
None
GOL  A 304 (-4.4A)
GOL  A 304 (-4.3A)
 0.94A 5n9xA-5m3qA:
undetectable		 5n9xA-5m3qA:
18.57