SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 4 HIS A  88
LEU A  80
LEU A 110
LEU A 372
 None
 1.16A 1a4lD-5m3xA:
undetectable		 1a4lD-5m3xA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 ALA A  71
VAL A  73
TRP A 133
 None
 0.79A 1av2C-5m3xA:
undetectable
1av2D-5m3xA:
undetectable		 1av2C-5m3xA:
undetectable
1av2D-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 4 THR A 180
LEU A 243
VAL A 388
LEU A 372
 None
 1.11A 1fbmB-5m3xA:
undetectable		 1fbmB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 ALA A  71
VAL A  73
TRP A 133
 None
 0.75A 1w5uC-5m3xA:
undetectable
1w5uD-5m3xA:
undetectable		 1w5uC-5m3xA:
undetectable
1w5uD-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 LEU A 125
ALA A 144
LEU A 194
LEU A 381
THR A 121
 None
 1.49A 1ya3B-5m3xA:
undetectable		 1ya3B-5m3xA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 LEU A 311
LEU A 310
ALA A 430
MET A 348
MET A 255
 None
 1.32A 2aa6A-5m3xA:
undetectable		 2aa6A-5m3xA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 TRP A 133
ALA A  71
VAL A  73
 None
 0.71A 2izqA-5m3xA:
undetectable
2izqB-5m3xA:
undetectable		 2izqA-5m3xA:
undetectable
2izqB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 5 GLN A 300
PHE A 286
LEU A 423
PHE A 427
 None
 1.39A 3ablC-5m3xA:
undetectable
3ablJ-5m3xA:
undetectable		 3ablC-5m3xA:
undetectable
3ablJ-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 11 LEU A 172
ALA A 105
VAL A 159
LEU A  51
PHE A 441
 None
 1.21A 3bszE-5m3xA:
undetectable		 3bszE-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 ASN A 246
ASP A 358
ARG A 385
 None
 0.92A 3k13A-5m3xA:
undetectable		 3k13A-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 SER A 290
LEU A 428
PHE A 427
LEU A 320
ASP A 319
 None
 1.11A 3ko0G-5m3xA:
undetectable
3ko0H-5m3xA:
0.4
3ko0I-5m3xA:
0.5
3ko0J-5m3xA:
undetectable		 3ko0G-5m3xA:
21.74
3ko0H-5m3xA:
21.74
3ko0I-5m3xA:
21.74
3ko0J-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 LEU A 320
ASP A 319
LEU A 428
PHE A 427
SER A 290
 None
 1.16A 3ko0K-5m3xA:
undetectable
3ko0L-5m3xA:
undetectable
3ko0M-5m3xA:
undetectable
3ko0N-5m3xA:
undetectable		 3ko0K-5m3xA:
21.74
3ko0L-5m3xA:
21.74
3ko0M-5m3xA:
21.74
3ko0N-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 LEU A 428
PHE A 427
LEU A 320
ASP A 319
SER A 290
 None
 1.11A 3ko0M-5m3xA:
undetectable
3ko0N-5m3xA:
undetectable
3ko0O-5m3xA:
undetectable
3ko0P-5m3xA:
undetectable		 3ko0M-5m3xA:
21.74
3ko0N-5m3xA:
21.74
3ko0O-5m3xA:
21.74
3ko0P-5m3xA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 ALA A  71
VAL A  73
TRP A 133
 None
 0.70A 3l8lA-5m3xA:
undetectable
3l8lB-5m3xA:
undetectable		 3l8lA-5m3xA:
undetectable
3l8lB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 ALA A  71
VAL A  73
TRP A 133
 None
 0.75A 3l8lC-5m3xA:
undetectable
3l8lD-5m3xA:
undetectable		 3l8lC-5m3xA:
undetectable
3l8lD-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 PHE A 258
GLN A 265
PHE A 286
 None
 0.69A 3rv5A-5m3xA:
undetectable		 3rv5A-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 10 ILE A  39
THR A 230
SER A 394
ILE A 218
THR A  43
 None
 1.33A 3um5A-5m3xA:
undetectable		 3um5A-5m3xA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 5 THR A 343
ILE A 344
GLU A 420
PHE A 258
 None
 1.45A 4ac9C-5m3xA:
undetectable		 4ac9C-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 5 THR A 343
ILE A 344
GLU A 420
PHE A 258
 None
 1.45A 4acaC-5m3xA:
undetectable		 4acaC-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 6 GLY A  93
TRP A  92
GLU A 324
ARG A 444
 None
 1.22A 4bqfA-5m3xA:
undetectable		 4bqfA-5m3xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 4 HIS A 288
GLU A 420
HIS A 345
LEU A 280
 None
 1.47A 4m2rA-5m3xA:
undetectable		 4m2rA-5m3xA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 10 VAL A  95
TYR A 357
GLY A 443
SER A 394
GLY A 355
 None
 1.26A 4mmdA-5m3xA:
1.2		 4mmdA-5m3xA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 ASN A 393
ILE A 395
ILE A 128
LEU A 129
GLY A  81
 None
 1.02A 4o1eA-5m3xA:
undetectable		 4o1eA-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		5 / 12 ASN A 393
ILE A 395
ILE A 128
LEU A 129
GLY A  81
 None
 1.07A 4o1eB-5m3xA:
undetectable		 4o1eB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 THR A 247
ASN A 393
SER A 394
 None
 0.73A 4tvtA-5m3xA:
undetectable		 4tvtA-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 VAL A 100
HIS A 440
VAL A 431
 None
 0.62A 5jmnC-5m3xA:
undetectable		 5jmnC-5m3xA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 6 PHE A 441
THR A 104
GLN A 155
TYR A 197
 None
 1.00A 6ag0A-5m3xA:
undetectable		 6ag0A-5m3xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 6 PHE A 441
THR A 104
GLN A 155
TYR A 197
 None
 1.03A 6ag0C-5m3xA:
undetectable		 6ag0C-5m3xA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 6 VAL A 301
LEU A 311
LEU A 423
LEU A 351
 None
 1.07A 6f6sA-5m3xA:
undetectable
6f6sB-5m3xA:
undetectable		 6f6sA-5m3xA:
24.44
6f6sB-5m3xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		3 / 3 PHE A  79
ARG A  83
GLN A 330
 None
 0.90A 6g1pB-5m3xA:
undetectable		 6g1pB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5m3x ANGIOTENSINOGEN
(Homo
sapiens) 		4 / 7 GLY A  97
HIS A  96
VAL A  94
SER A 394
 None
 0.73A 6hu9S-5m3xA:
undetectable
6hu9q-5m3xA:
undetectable		 6hu9S-5m3xA:
undetectable
6hu9q-5m3xA:
undetectable