SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m42'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.05A 1h9zA-5m42A:
undetectable		 1h9zA-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 150
LEU A  80
LEU A 132
LEU A  98
LEU A 146
 None
 1.22A 1mx1C-5m42A:
undetectable		 1mx1C-5m42A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 215
LEU A 211
LEU A 177
LEU A 174
THR A 169
 None
 1.31A 1tz8A-5m42A:
undetectable
1tz8B-5m42A:
undetectable		 1tz8A-5m42A:
18.86
1tz8B-5m42A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A 150
ARG A 117
LEU A 146
LEU A 100
ALA A 114
 None
 1.20A 2bxeA-5m42A:
undetectable		 2bxeA-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A 150
ARG A 117
LEU A 146
LEU A 100
ALA A 114
 None
 1.13A 2bxeB-5m42A:
undetectable		 2bxeB-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 TYR A 255
LEU A  51
GLU A  54
VAL A  56
GLN A 262
 None
 1.31A 2vqyA-5m42A:
undetectable		 2vqyA-5m42A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A 103
ARG A 121
LEU A 120
ALA A 114
 None
 1.18A 3b9mA-5m42A:
undetectable		 3b9mA-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A 132
ARG A 117
LEU A 120
ALA A 149
 None
 1.14A 3b9mA-5m42A:
undetectable		 3b9mA-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ILE A  59
PHE A 129
VAL A 161
GLY A 159
 None
None
FMN  A2001 (-4.3A)
None
 0.76A 4acbC-5m42A:
2.9		 4acbC-5m42A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A  87
LEU A  62
GLN A 157
GLU A 122
 None
 1.06A 4i41A-5m42A:
undetectable		 4i41A-5m42A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LYS A 213
LEU A 235
GLU A 234
TYR A 238
 None
 1.42A 4olbA-5m42A:
undetectable		 4olbA-5m42A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 100
ASP A 106
GLU A 109
ILE A 160
 None
 1.09A 4xi3C-5m42A:
undetectable		 4xi3C-5m42A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A 253
PHE A 224
LEU A 216
GLY A 243
MET A 242
 None
 1.23A 4zjlA-5m42A:
undetectable		 4zjlA-5m42A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A 273
TYR A 221
GLU A 250
 None
 0.69A 4zzbE-5m42A:
undetectable		 4zzbE-5m42A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LYS A 213
LEU A 235
GLU A 234
TYR A 238
 None
 1.39A 5js1A-5m42A:
undetectable		 5js1A-5m42A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LYS A 171
ASP A 175
ARG A 168
 None
 0.94A 5jwaA-5m42A:
undetectable
5jwaH-5m42A:
2.1		 5jwaA-5m42A:
19.96
5jwaH-5m42A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5m42 PROLINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLN A  77
LEU A  80
TRP A  85
ALA A  86
 None
 0.83A 5nwvA-5m42A:
undetectable		 5nwvA-5m42A:
9.09