SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 8 GLY A 272
GLY A  55
LEU A  34
ASP A  44
 None
 0.87A 1aegA-5m49A:
undetectable		 1aegA-5m49A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.99A 1fm6A-5m49A:
undetectable		 1fm6A-5m49A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.98A 1k74A-5m49A:
undetectable		 1k74A-5m49A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 VAL A  26
ALA A 378
SER A  46
LEU A 395
TYR A  56
 None
 1.40A 1kiaD-5m49A:
2.1		 1kiaD-5m49A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.98A 1xiuA-5m49A:
undetectable		 1xiuA-5m49A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 ALA A 280
ILE A 284
VAL A 236
PHE A 203
ILE A 233
 None
 0.96A 1xozA-5m49A:
undetectable		 1xozA-5m49A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 11 ALA A 280
ILE A 284
VAL A 236
PHE A 203
ILE A 233
 None
 1.07A 2h42A-5m49A:
undetectable		 2h42A-5m49A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 11 ASN A 114
ILE A 284
VAL A 236
PHE A 203
ILE A 233
 PLP  A 501 ( 4.8A)
None
None
None
None
 1.06A 2h42A-5m49A:
undetectable		 2h42A-5m49A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 LEU A  54
GLY A 268
GLY A  50
GLY A 272
GLY A 271
 None
 0.90A 3axzA-5m49A:
undetectable		 3axzA-5m49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 LEU A 414
ALA A 418
GLU A 421
ILE A  43
LEU A 385
 None
 1.13A 3olsB-5m49A:
undetectable		 3olsB-5m49A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 5 LEU A 310
LEU A 269
GLY A 268
GLY A 270
 None
 0.73A 3si7C-5m49A:
undetectable
3si7D-5m49A:
undetectable		 3si7C-5m49A:
20.09
3si7D-5m49A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 6 SER A 247
GLY A 219
ASP A 218
GLY A 257
 None
 0.94A 4koeA-5m49A:
1.1
4koeB-5m49A:
0.9
4koeC-5m49A:
undetectable		 4koeA-5m49A:
22.93
4koeB-5m49A:
22.93
4koeC-5m49A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 7 SER A 247
GLY A 219
ASP A 218
GLY A 257
 None
 0.96A 4koeA-5m49A:
1.1
4koeB-5m49A:
undetectable
4koeD-5m49A:
undetectable		 4koeA-5m49A:
22.93
4koeB-5m49A:
22.93
4koeD-5m49A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 10 ASP A 238
VAL A 240
VAL A 264
SER A 109
SER A 276
 PLP  A 501 (-2.7A)
PLP  A 501 (-4.2A)
None
PLP  A 501 (-3.7A)
None
 1.49A 4ldoA-5m49A:
undetectable		 4ldoA-5m49A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 10 ASP A 112
VAL A 264
GLY A 139
SER A 109
GLY A 266
 None
None
PLP  A 501 ( 3.9A)
PLP  A 501 (-3.7A)
None
 1.37A 4mmcA-5m49A:
undetectable		 4mmcA-5m49A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 PRO A 206
GLU A 205
CYH A 237
ASN A 114
GLY A 110
 None
PLP  A 501 (-4.0A)
None
PLP  A 501 ( 4.8A)
PLP  A 501 (-3.2A)
 1.31A 4oadA-5m49A:
undetectable		 4oadA-5m49A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 GLY A 271
GLY A 272
GLY A  50
ALA A  48
SER A 247
 None
 1.01A 4rtmA-5m49A:
undetectable		 4rtmA-5m49A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 LEU A  54
GLY A 268
GLY A  50
GLY A 272
GLY A 271
 None
 0.94A 4yvgA-5m49A:
undetectable		 4yvgA-5m49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 6 GLY A 219
ASP A 218
GLY A 257
SER A 247
 None
 0.93A 4z53A-5m49A:
undetectable
4z53B-5m49A:
undetectable		 4z53A-5m49A:
18.68
4z53B-5m49A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 GLY A 270
GLY A 272
GLY A  55
LEU A  54
LEU A 269
 None
 1.00A 5c0oE-5m49A:
undetectable		 5c0oE-5m49A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 9 ALA A 277
GLY A 266
LEU A 269
LEU A  92
GLU A 239
 None
 1.19A 5dqfA-5m49A:
undetectable		 5dqfA-5m49A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 9 ALA A 411
LEU A  42
GLY A 382
LEU A 383
LEU A  45
 None
 1.18A 5dqfA-5m49A:
undetectable		 5dqfA-5m49A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A  92
 None
 1.14A 5dzkb-5m49A:
undetectable
5dzkp-5m49A:
undetectable		 5dzkb-5m49A:
20.95
5dzkp-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 6 SER A  95
ALA A  94
HIS A 251
LEU A  92
 None
 1.12A 5dzkB-5m49A:
undetectable
5dzkP-5m49A:
undetectable		 5dzkB-5m49A:
20.95
5dzkP-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A  92
 None
 1.12A 5dzkc-5m49A:
undetectable
5dzkq-5m49A:
undetectable		 5dzkc-5m49A:
20.95
5dzkq-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A 310
 None
 1.41A 5dzkf-5m49A:
undetectable
5dzkt-5m49A:
undetectable		 5dzkf-5m49A:
20.95
5dzkt-5m49A:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 8 LEU A 191
ILE A 131
ALA A 202
PHE A 224
 None
 0.84A 5m0oC-5m49A:
undetectable		 5m0oC-5m49A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		3 / 3 HIS A 108
ASP A 112
HIS A 297
 None
 0.96A 5n1tW-5m49A:
undetectable		 5n1tW-5m49A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		4 / 8 HIS A  58
VAL A 309
LEU A 401
THR A 402
 None
 0.95A 5tt3H-5m49A:
undetectable		 5tt3H-5m49A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
 None
 0.94A 5uanA-5m49A:
undetectable		 5uanA-5m49A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 GLY A 211
GLY A 212
LEU A 213
PRO A 260
PRO A 170
 None
 1.10A 6gngB-5m49A:
undetectable		 6gngB-5m49A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5m49 AMINOTRANSFERASE
CLASS-III
(Rhizobium
freirei) 		5 / 12 LEU A 250
ILE A 313
LEU A 269
GLY A 268
ALA A 305
 None
 0.85A 6qxsD-5m49A:
undetectable		 6qxsD-5m49A:
21.71