SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.06A 1dlsA-5m4aA:
undetectable		 1dlsA-5m4aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.12A 1drfA-5m4aA:
undetectable		 1drfA-5m4aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 344
VAL A 368
GLY A 308
LEU A 306
 None
 0.59A 1dzmA-5m4aA:
undetectable		 1dzmA-5m4aA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 637
HIS A 633
ARG A 652
ALA A 605
LEU A 598
 None
 1.21A 1mjlA-5m4aA:
undetectable
1mjlB-5m4aA:
undetectable		 1mjlA-5m4aA:
11.99
1mjlB-5m4aA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 637
HIS A 633
GLU A 599
ARG A 652
ALA A 605
 None
 1.15A 1mjlA-5m4aA:
undetectable
1mjlB-5m4aA:
undetectable		 1mjlA-5m4aA:
11.99
1mjlB-5m4aA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 296
ARG A 199
TYR A 351
TYR A 352
 None
None
None
TRE  A 801 (-4.8A)
 1.18A 2ajvH-5m4aA:
undetectable
2ajvL-5m4aA:
undetectable		 2ajvH-5m4aA:
17.29
2ajvL-5m4aA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 414
HIS A 415
PRO A 416
HIS A 468
 None
 1.01A 2ombC-5m4aA:
undetectable
2ombD-5m4aA:
undetectable		 2ombC-5m4aA:
17.01
2ombD-5m4aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 579
PHE A 360
ILE A 635
PRO A 632
LEU A 316
 None
 1.17A 2w3bB-5m4aA:
undetectable		 2w3bB-5m4aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 382
ARG A 328
VAL A 331
ILE A 335
 None
 0.90A 2yfbB-5m4aA:
undetectable		 2yfbB-5m4aA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 399
GLU A 394
ARG A 539
ILE A 506
 None
 1.32A 3e7gC-5m4aA:
undetectable
3e7gD-5m4aA:
undetectable		 3e7gC-5m4aA:
23.58
3e7gD-5m4aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 714
ILE A 189
GLY A 705
PHE A 706
LEU A 318
 None
None
None
TRE  A 801 (-4.7A)
None
 1.28A 3elzB-5m4aA:
undetectable		 3elzB-5m4aA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 267
TYR A 263
TYR A 226
GLU A 253
 None
 0.99A 3q5sA-5m4aA:
undetectable		 3q5sA-5m4aA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 10 GLN A 357
MET A 330
ASN A 348
GLY A 308
GLY A 300
 TRE  A 801 (-3.7A)
None
None
None
None
 1.35A 3v3oD-5m4aA:
undetectable		 3v3oD-5m4aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 414
ARG A 482
HIS A 477
 None
 1.23A 4fubA-5m4aA:
undetectable		 4fubA-5m4aA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 421
PRO A 422
ARG A 470
GLY A 471
 None
 0.56A 4g0uB-5m4aA:
2.0		 4g0uB-5m4aA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 210
GLY A 207
GLU A 208
GLY A 293
TYR A 296
 None
 1.31A 4jdsA-5m4aA:
undetectable		 4jdsA-5m4aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 206
TYR A 238
ALA A 241
 None
 0.46A 4ybnA-5m4aA:
undetectable		 4ybnA-5m4aA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.40A 4z4fA-5m4aA:
undetectable		 4z4fA-5m4aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 591
ALA A 594
PHE A 574
THR A 573
 None
 1.37A 4z4hA-5m4aA:
undetectable		 4z4hA-5m4aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 300
GLU A 704
ALA A 701
ASN A 304
 None
 1.00A 5mvsA-5m4aA:
undetectable		 5mvsA-5m4aA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 437
ASP A 446
LEU A 445
PHE A 448
 None
 1.02A 5nooC-5m4aA:
undetectable		 5nooC-5m4aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5m4a NEUTRAL TREHALASE
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 478
ARG A 473
VAL A 709
ARG A 199
 TRE  A 801 (-2.8A)
TRE  A 801 (-4.2A)
None
None
 1.09A 6fbvD-5m4aA:
undetectable		 6fbvD-5m4aA:
18.43