SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8D_A_BEZA1001_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5m4s	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 (Homo sapiens)	4 / 6	VAL A 119 SER A 118 ARG A 51 LEU A 48	None	1.34A	2f8dA-5m4sA: undetectable	2f8dA-5m4sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HAV_A_SRYA403_1 (AMINOGLYCOSIDE PHOSPHOTRANSFERASE)	5m4s	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 (Homo sapiens)	4 / 8	ASP A 122 SER A 118 ASP A 126 ASP A 189	None	1.13A	3havA-5m4sA: 2.1	3havA-5m4sA: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XNX_A_41XA707_1 (TRANSPORTER)	5m4s	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 (Homo sapiens)	5 / 11	ASP A 198 ALA A 47 VAL A 119 GLY A 190 VAL A 52	None	1.22A	4xnxA-5m4sA: undetectable	4xnxA-5m4sA: 10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_C_ACTC608_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	5m4s	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 (Homo sapiens)	4 / 5	TYR A 173 LYS A 188 GLN A 172 TYR A 3	None	1.25A	6b58C-5m4sA: 0.4	6b58C-5m4sA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DIF_B_TPVB201_0 (HIV-1 PROTEASE)	5m4s	TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1 (Homo sapiens)	5 / 12	ALA A 97 GLY A 190 ILE A 191 VAL A 93 ILE A 95	None	1.17A	6difA-5m4sA: undetectable	6difA-5m4sA: 21.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2F8D_A_BEZA1001_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5m4s","TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1","Homo sapiens",4,"VAL A 119;SER A 118;ARG A  51;LEU A  48","None","1.34A","2f8dA-5m4sA:undetectable","2f8dA-5m4sA:undetectable"],["3HAV_A_SRYA403_1","AMINOGLYCOSIDE PHOSPHOTRANSFERASE","5m4s","TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1","Homo sapiens",4,"ASP A 122;SER A 118;ASP A 126;ASP A 189","None","1.13A","3havA-5m4sA:2.1","3havA-5m4sA:14.95"],["4XNX_A_41XA707_1","TRANSPORTER","5m4s","TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1","Homo sapiens",5,"ASP A 198;ALA A  47;VAL A 119;GLY A 190;VAL A  52","None","1.22A","4xnxA-5m4sA:undetectable","4xnxA-5m4sA:10.06"],["6B58_C_ACTC608_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","5m4s","TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1","Homo sapiens",4,"TYR A 173;LYS A 188;GLN A 172;TYR A   3","None","1.25A","6b58C-5m4sA:0.4","6b58C-5m4sA:undetectable"],["6DIF_B_TPVB201_0","HIV-1 PROTEASE","5m4s","TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1,TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1","Homo sapiens",5,"ALA A  97;GLY A 190;ILE A 191;VAL A  93;ILE A  95","None","1.17A","6difA-5m4sA:undetectable","6difA-5m4sA:21.35"]]