SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.72A 1eizA-5m58A:
12.2		 1eizA-5m58A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 ASP A  70
ASP A  74
ASP A  96
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.5A)
 0.73A 1ej0A-5m58A:
12.1		 1ej0A-5m58A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 ALA A 219
VAL A 221
TRP A 210
 None
 1.01A 1gmkA-5m58A:
undetectable
1gmkB-5m58A:
undetectable		 1gmkA-5m58A:
7.91
1gmkB-5m58A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 4 VAL A 162
TRP A 170
TRP A 161
 None
 1.03A 1gmkA-5m58A:
undetectable
1gmkB-5m58A:
undetectable		 1gmkA-5m58A:
7.91
1gmkB-5m58A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 ASP A  70
HIS A  15
GLY A  49
GLY A  18
TYR A  25
 SAH  A 301 (-2.8A)
None
SAH  A 301 (-3.3A)
None
SAH  A 301 (-4.5A)
 1.08A 1zz1C-5m58A:
undetectable		 1zz1C-5m58A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		4 / 7 GLY A  49
TYR A  25
ASP A  70
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 (-4.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.97A 2g72B-5m58A:
13.0		 2g72B-5m58A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 GLY A  49
LEU A  71
SER A  72
MET A  75
LEU A 122
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.5A)
 0.71A 3bxoA-5m58A:
17.5		 3bxoA-5m58A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 TYR A  25
GLY A  49
SER A  72
ASP A  96
ARG A 116
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.3A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.9A)
 0.78A 3dlcA-5m58A:
21.0		 3dlcA-5m58A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.46A 3ou7C-5m58A:
13.8		 3ou7C-5m58A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 GLY A  49
LEU A  71
SER A  72
MET A  75
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.5A)
 0.48A 3pfgA-5m58A:
7.8		 3pfgA-5m58A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 HIS A 117
LEU A  71
SER A  72
MET A  75
ASP A  96
 None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.5A)
 1.27A 3pfgA-5m58A:
7.8		 3pfgA-5m58A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 HIS A 117
ARG A 116
GLU A  27
 None
SAH  A 301 (-3.9A)
None
 0.98A 3qf1A-5m58A:
undetectable		 3qf1A-5m58A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fp9D-5m58A:
12.6		 4fp9D-5m58A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 CYH A  47
GLY A  51
LEU A  71
SER A  72
ASP A  96
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
 0.58A 4fzvA-5m58A:
11.4		 4fzvA-5m58A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
GLN A  98
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.2A)
 0.74A 4htfA-5m58A:
15.7		 4htfA-5m58A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
GLN A  98
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
SAH  A 301 ( 4.2A)
 0.72A 4htfB-5m58A:
15.5		 4htfB-5m58A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		6 / 12 GLY A  49
ASP A  70
ASP A  96
ARG A 116
ALA A 118
LEU A 122
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
 0.80A 4iv8A-5m58A:
17.5		 4iv8A-5m58A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		6 / 12 GLY A  49
ASP A  70
MET A  75
ASP A  96
ARG A 116
ALA A 118
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.5A)
 0.92A 4iv8A-5m58A:
17.5		 4iv8A-5m58A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		6 / 12 GLY A  49
ASP A  70
ASP A  96
ARG A 116
ALA A 118
LEU A 122
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
 0.81A 4iv8B-5m58A:
17.5		 4iv8B-5m58A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		3 / 3 ARG A 116
ASP A  70
ASP A  96
 SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.47A 4kicB-5m58A:
16.2		 4kicB-5m58A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		6 / 12 GLY A  49
LEU A  71
SER A  72
ASP A  96
ALA A  97
ARG A 116
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.9A)
 0.76A 4krhA-5m58A:
18.6		 4krhA-5m58A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 GLY A  49
LEU A  71
SER A  72
ALA A  97
ARG A 116
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.9A)
 0.69A 4krhB-5m58A:
18.7		 4krhB-5m58A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		4 / 7 VAL A 218
TRP A 161
PHE A 147
HIS A 120
 None
 1.42A 5ad9A-5m58A:
undetectable
5ad9B-5m58A:
undetectable		 5ad9A-5m58A:
19.34
5ad9B-5m58A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		4 / 4 ASP A  45
GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 ( 4.8A)
SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.38A 5e72A-5m58A:
14.8		 5e72A-5m58A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 5m58 C-METHYLTRANSFERASE
COUO
(Streptomyces
rishiriensis) 		5 / 12 TYR A 191
SER A 146
VAL A 221
LEU A 143
PHE A 129
 None
 1.15A 5g6sB-5m58A:
4.2
5g6sC-5m58A:
4.1		 5g6sB-5m58A:
21.68
5g6sC-5m58A:
21.68