SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
 None
 0.82A 1bx4A-5m5jA:
undetectable		 1bx4A-5m5jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 10 GLY A  18
VAL A  36
VAL A  34
ALA A  72
ILE A  23
 None
FAD  A1001 (-4.4A)
None
None
None
 1.07A 1likA-5m5jA:
undetectable		 1likA-5m5jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 11 LEU A  79
GLY A  18
GLY A  22
ILE A  68
PRO A  62
 None
 1.23A 1p91A-5m5jA:
2.3		 1p91A-5m5jA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 VAL A 278
ILE A 112
ILE A  12
PHE A 249
ILE A  96
 None
None
None
FAD  A1001 ( 4.7A)
None
 0.99A 1qhsA-5m5jA:
undetectable		 1qhsA-5m5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		6 / 12 VAL A 278
ILE A  12
PHE A 249
ILE A  96
VAL A  89
GLN A 254
 None
None
FAD  A1001 ( 4.7A)
None
None
None
 1.24A 1qhyA-5m5jA:
undetectable		 1qhyA-5m5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		6 / 12 VAL A 278
ILE A 112
ILE A  12
PHE A 249
ILE A  96
VAL A  89
 None
None
None
FAD  A1001 ( 4.7A)
None
None
 1.11A 1qhyA-5m5jA:
undetectable		 1qhyA-5m5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		4 / 8 PHE A  53
SER A  55
ALA A  67
LEU A  64
 None
 0.97A 2o01A-5m5jA:
undetectable		 2o01A-5m5jA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 THR A 105
LEU A 106
GLN A 254
PHE A  35
VAL A  84
 None
None
None
None
FAD  A1001 (-3.7A)
 1.47A 2vaxH-5m5jA:
undetectable		 2vaxH-5m5jA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 GLY A  22
ALA A  21
GLY A  14
VAL A  36
ILE A 111
 None
None
FAD  A1001 (-3.3A)
FAD  A1001 (-4.4A)
None
 1.03A 3cyxA-5m5jA:
undetectable		 3cyxA-5m5jA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 LEU A 265
GLY A 299
GLY A  22
ALA A 280
ILE A  11
 None
 0.86A 3ku1H-5m5jA:
2.6		 3ku1H-5m5jA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 ASP A 141
VAL A 219
ARG A 230
ILE A 221
ALA A 136
 FAD  A1001 ( 4.1A)
None
None
None
FAD  A1001 ( 4.0A)
 1.15A 3ohtA-5m5jA:
undetectable
3ohtB-5m5jA:
undetectable		 3ohtA-5m5jA:
21.31
3ohtB-5m5jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 GLY A  22
ALA A  21
GLY A  14
VAL A  36
ILE A 111
 None
None
FAD  A1001 (-3.3A)
FAD  A1001 (-4.4A)
None
 0.89A 3oxxC-5m5jA:
undetectable		 3oxxC-5m5jA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 ILE A   9
SER A 274
ALA A 280
ILE A  87
LEU A 250
 None
 1.12A 3w67C-5m5jA:
undetectable		 3w67C-5m5jA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 GLY A  10
ALA A 109
LEU A  30
VAL A   7
HIS A   6
 None
 1.27A 4azsA-5m5jA:
undetectable		 4azsA-5m5jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 11 GLY A 282
GLY A 115
ILE A 112
ASP A 283
PRO A  16
 FAD  A1001 (-3.3A)
FAD  A1001 (-3.3A)
None
FAD  A1001 (-3.0A)
FAD  A1001 (-3.9A)
 1.08A 4dcmA-5m5jA:
2.6		 4dcmA-5m5jA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 ALA A 302
GLY A  22
GLY A  18
LEU A  79
ALA A 303
 None
 1.14A 4lg1B-5m5jA:
3.0		 4lg1B-5m5jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 ALA A 302
GLY A  22
GLY A  18
LEU A  79
ALA A 303
 None
 1.15A 4lg1C-5m5jA:
undetectable		 4lg1C-5m5jA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		4 / 8 ALA A  28
GLU A 307
ILE A   9
ILE A  11
 None
 0.91A 4ndnD-5m5jA:
undetectable		 4ndnD-5m5jA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		4 / 8 ALA A 281
GLY A 299
ALA A  21
GLY A  18
 None
 0.69A 4zjzA-5m5jA:
undetectable		 4zjzA-5m5jA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
 None
 0.79A 5kb6A-5m5jA:
3.6		 5kb6A-5m5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 THR A  32
GLY A  10
ALA A  21
GLY A  22
ALA A 303
 None
 0.79A 5kb6B-5m5jA:
undetectable		 5kb6B-5m5jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		4 / 8 ALA A  28
GLU A 307
ILE A   9
ILE A  11
 None
 0.87A 5t8sA-5m5jA:
undetectable		 5t8sA-5m5jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 11 ALA A  77
VAL A 278
ILE A 112
THR A 114
ILE A  87
 None
None
None
FAD  A1001 (-3.9A)
None
 0.99A 5y80A-5m5jA:
undetectable		 5y80A-5m5jA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 10 GLY A  13
VAL A  84
ASP A  83
THR A 114
ILE A 112
 FAD  A1001 (-3.1A)
FAD  A1001 (-3.7A)
None
FAD  A1001 (-3.9A)
None
 1.10A 6exiA-5m5jA:
3.2		 6exiA-5m5jA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 10 GLY A  13
VAL A  84
ASP A  83
THR A 114
ILE A 112
 FAD  A1001 (-3.1A)
FAD  A1001 (-3.7A)
None
FAD  A1001 (-3.9A)
None
 1.12A 6exiB-5m5jA:
3.2		 6exiB-5m5jA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5m5j THIOREDOXIN
REDUCTASE
(Giardia
intestinalis) 		5 / 12 GLY A  13
VAL A  84
ASP A  83
THR A 114
ILE A 112
 FAD  A1001 (-3.1A)
FAD  A1001 (-3.7A)
None
FAD  A1001 (-3.9A)
None
 1.11A 6exiC-5m5jA:
3.6
6exiD-5m5jA:
3.6		 6exiC-5m5jA:
13.65
6exiD-5m5jA:
13.65