SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1194
ARG A1198
ILE A1227
 None
 0.86A 1a4gB-5m5pA:
undetectable		 1a4gB-5m5pA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 1c9sC-5m5pA:
undetectable
1c9sD-5m5pA:
undetectable		 1c9sC-5m5pA:
3.64
1c9sD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 1c9sF-5m5pA:
undetectable
1c9sG-5m5pA:
undetectable		 1c9sF-5m5pA:
3.64
1c9sG-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 1c9sJ-5m5pA:
undetectable
1c9sK-5m5pA:
undetectable		 1c9sJ-5m5pA:
3.64
1c9sK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 THR A 528
LEU A 532
VAL A 535
LEU A 539
 None
 0.52A 1fbmB-5m5pA:
undetectable		 1fbmB-5m5pA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 1gtfA-5m5pA:
undetectable
1gtfK-5m5pA:
undetectable		 1gtfA-5m5pA:
3.64
1gtfK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 1gtfB-5m5pA:
undetectable
1gtfC-5m5pA:
undetectable		 1gtfB-5m5pA:
3.64
1gtfC-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 1gtfE-5m5pA:
undetectable
1gtfF-5m5pA:
undetectable		 1gtfE-5m5pA:
3.64
1gtfF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 1gtfF-5m5pA:
undetectable
1gtfG-5m5pA:
undetectable		 1gtfF-5m5pA:
3.64
1gtfG-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1568
ILE A1605
LYS A1600
ALA A1597
 None
 1.21A 1hk2A-5m5pA:
undetectable		 1hk2A-5m5pA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 CYH A1510
ASN A1399
ALA A1383
LEU A1384
LEU A1470
 None
 1.37A 1hwiA-5m5pA:
1.2		 1hwiA-5m5pA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1477
GLY A1369
ASP A1475
PHE A1367
ASP A1474
 None
 1.40A 1t69A-5m5pA:
4.6		 1t69A-5m5pA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.49A 1utdA-5m5pA:
undetectable
1utdB-5m5pA:
undetectable		 1utdA-5m5pA:
3.64
1utdB-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 THR A 844
GLY A 737
GLN A 739
ILE A 741
PHE A 820
 None
 1.35A 2akeA-5m5pA:
3.3		 2akeA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 793
ALA A 754
ILE A 801
CYH A 830
HIS A 805
 None
 1.44A 2b17A-5m5pA:
undetectable		 2b17A-5m5pA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 SER A 733
ASP A 881
CYH A 701
 None
 0.99A 2br4E-5m5pA:
2.5		 2br4E-5m5pA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.28A 2e7fA-5m5pA:
undetectable		 2e7fA-5m5pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.23A 2e7fB-5m5pA:
undetectable		 2e7fB-5m5pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A2038
VAL A2041
VAL A2045
ILE A2019
ILE A2030
 None
 1.10A 2gj5A-5m5pA:
undetectable		 2gj5A-5m5pA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 529
ILE A 502
GLN A 503
THR A 496
 None
 1.16A 2hkkA-5m5pA:
undetectable		 2hkkA-5m5pA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 796
VAL A 827
ILE A 734
ALA A 754
ILE A 801
 None
 0.97A 2idwA-5m5pA:
undetectable		 2idwA-5m5pA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.10A 2j7xA-5m5pA:
undetectable		 2j7xA-5m5pA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.26A 2ogyA-5m5pA:
undetectable		 2ogyA-5m5pA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.20A 2ogyB-5m5pA:
undetectable		 2ogyB-5m5pA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 THR A1875
THR A1975
ASP A1989
ASP A1991
 None
 1.24A 2okcA-5m5pA:
2.2		 2okcA-5m5pA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 422
ASP A 994
TYR A 989
HIS A 975
 None
 1.43A 2pncB-5m5pA:
undetectable		 2pncB-5m5pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 ILE A1762
ARG A1458
ARG A1462
ILE A1465
 None
 1.13A 2q72A-5m5pA:
undetectable		 2q72A-5m5pA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 10 ASP A1946
ARG A1895
SER A1558
ILE A1557
GLY A1690
 None
 1.38A 2v0mA-5m5pA:
undetectable		 2v0mA-5m5pA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A1641
SER A1667
CYH A1670
GLN A1944
 None
 1.29A 2xz5A-5m5pA:
2.9
2xz5B-5m5pA:
3.1		 2xz5A-5m5pA:
8.15
2xz5B-5m5pA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1789
GLU A1743
ASN A1517
 None
 1.00A 2y7hC-5m5pA:
undetectable		 2y7hC-5m5pA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 SER A1921
GLU A1267
ASP A1225
 None
 0.69A 2zulA-5m5pA:
3.6		 2zulA-5m5pA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1763
ASN A1755
SER A1854
SER A1761
 None
 1.11A 2zw9B-5m5pA:
3.2		 2zw9B-5m5pA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 SER A1921
GLU A1267
ASP A1225
 None
 0.72A 3dmhA-5m5pA:
4.6		 3dmhA-5m5pA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 796
VAL A 827
ILE A 734
ALA A 754
ILE A 801
 None
 1.01A 3el0B-5m5pA:
undetectable		 3el0B-5m5pA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 350
GLN A 332
LEU A 334
GLU A 331
 None
 1.09A 3h5gB-5m5pA:
undetectable
3h5gC-5m5pA:
undetectable		 3h5gB-5m5pA:
2.89
3h5gC-5m5pA:
2.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 981
VAL A 957
VAL A 913
ILE A 427
 None
 1.15A 3k5vA-5m5pA:
undetectable		 3k5vA-5m5pA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1960
LEU A1957
SER A1868
GLY A1850
ALA A1853
 None
 1.06A 3kk6A-5m5pA:
undetectable		 3kk6A-5m5pA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1803
SER A1800
PHE A1802
ILE A1782
 None
 0.98A 3ko0B-5m5pA:
undetectable		 3ko0B-5m5pA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 SER A1401
ASP A1475
ASN A1513
 None
 0.94A 3lslA-5m5pA:
undetectable
3lslD-5m5pA:
1.5		 3lslA-5m5pA:
9.10
3lslD-5m5pA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1807
ILE A1782
PHE A1773
SER A1744
ILE A1750
 None
 1.12A 3qfxA-5m5pA:
undetectable		 3qfxA-5m5pA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1807
ILE A1782
PHE A1773
SER A1744
ILE A1750
 None
 1.10A 3qfxB-5m5pA:
undetectable		 3qfxB-5m5pA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 TYR A1254
GLU A1114
LEU A1240
PHE A1113
 None
 0.90A 3rqwC-5m5pA:
2.2
3rqwD-5m5pA:
2.4		 3rqwC-5m5pA:
10.69
3rqwD-5m5pA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 TYR A1254
GLU A1114
LEU A1240
PHE A1113
 None
 0.91A 3rqwI-5m5pA:
undetectable
3rqwJ-5m5pA:
undetectable		 3rqwI-5m5pA:
10.69
3rqwJ-5m5pA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 GLU A1114
LEU A1240
PHE A1113
TYR A1254
 None
 0.95A 3rqwF-5m5pA:
undetectable
3rqwJ-5m5pA:
undetectable		 3rqwF-5m5pA:
10.69
3rqwJ-5m5pA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A2128
LEU A2103
LEU A2057
SER A2056
 None
 0.91A 3vhuA-5m5pA:
undetectable		 3vhuA-5m5pA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 646
VAL A 625
ILE A 633
LEU A 631
VAL A 628
 None
 1.02A 3w68B-5m5pA:
undetectable		 3w68B-5m5pA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1713
ASP A1678
ASN A1579
 None
 0.80A 4agaA-5m5pA:
undetectable		 4agaA-5m5pA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 SER A1776
TYR A1779
TRP A1772
PHE A1773
 None
 1.30A 4awuA-5m5pA:
undetectable		 4awuA-5m5pA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 SER A1776
TYR A1779
TRP A1772
PHE A1778
 None
 1.50A 4awuA-5m5pA:
undetectable		 4awuA-5m5pA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 TRP A1121
LEU A1022
LEU A1128
THR A1125
 None
 1.25A 4bboD-5m5pA:
undetectable		 4bboD-5m5pA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 HIS A1635
LEU A1610
MET A1609
ASP A1608
 None
 1.26A 4cevA-5m5pA:
3.3
4cevB-5m5pA:
3.2		 4cevA-5m5pA:
10.25
4cevB-5m5pA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 MET A1609
ASP A1608
HIS A1635
LEU A1610
 None
 1.27A 4cevA-5m5pA:
3.3
4cevC-5m5pA:
2.1		 4cevA-5m5pA:
10.25
4cevC-5m5pA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 HIS A1635
LEU A1610
MET A1609
ASP A1608
 None
 1.28A 4cevD-5m5pA:
4.7
4cevE-5m5pA:
4.0		 4cevD-5m5pA:
10.25
4cevE-5m5pA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 HIS A1635
LEU A1610
MET A1609
ASP A1608
 None
 1.25A 4cevE-5m5pA:
4.0
4cevF-5m5pA:
3.9		 4cevE-5m5pA:
10.25
4cevF-5m5pA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 PRO A1124
LEU A1031
ILE A1034
ARG A1033
 None
 1.23A 4f4dA-5m5pA:
undetectable		 4f4dA-5m5pA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.09A 4j24A-5m5pA:
undetectable		 4j24A-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.10A 4j24C-5m5pA:
undetectable		 4j24C-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.11A 4j24D-5m5pA:
undetectable		 4j24D-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.12A 4j26A-5m5pA:
undetectable		 4j26A-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 670
LEU A 518
ILE A 908
HIS A 640
LEU A 638
 None
 1.12A 4j26B-5m5pA:
undetectable		 4j26B-5m5pA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.35A 4jkuB-5m5pA:
undetectable		 4jkuB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.35A 4k8pA-5m5pA:
undetectable		 4k8pA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k8pB-5m5pA:
1.1		 4k8pB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k8tA-5m5pA:
undetectable		 4k8tA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k8tB-5m5pA:
undetectable		 4k8tB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.35A 4k93A-5m5pA:
undetectable		 4k93A-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k93B-5m5pA:
undetectable		 4k93B-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.35A 4k9cA-5m5pA:
undetectable		 4k9cA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k9cB-5m5pA:
undetectable		 4k9cB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k9iA-5m5pA:
undetectable		 4k9iA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_2
(SUGAR KINASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4k9iB-5m5pA:
undetectable		 4k9iB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4kadA-5m5pA:
undetectable		 4kadA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.37A 4kadB-5m5pA:
1.3		 4kadB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 ARG A1781
ASP A1793
GLY A1310
PRO A1210
 None
 1.07A 4l1aB-5m5pA:
undetectable		 4l1aB-5m5pA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.38A 4lbxA-5m5pA:
undetectable		 4lbxA-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.37A 4lbxB-5m5pA:
undetectable		 4lbxB-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.36A 4lc4A-5m5pA:
undetectable		 4lc4A-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A 900
ILE A 908
TYR A 897
PRO A 675
 None
 1.37A 4lc4B-5m5pA:
undetectable		 4lc4B-5m5pA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1933
LEU A1880
ASP A1989
VAL A1962
 None
 1.20A 4nkvA-5m5pA:
undetectable		 4nkvA-5m5pA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 ARG A1457
ASN A1755
ALA A1853
GLY A1850
LEU A1851
 None
 1.37A 4oadA-5m5pA:
undetectable		 4oadA-5m5pA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A1511
LEU A1384
HIS A1387
ILE A1506
 None
 0.88A 4ok1A-5m5pA:
undetectable		 4ok1A-5m5pA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.25A 4olaA-5m5pA:
1.0		 4olaA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.13A 4olbA-5m5pA:
2.3		 4olbA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 506
ILE A 668
ALA A 531
ILE A 633
 None
 0.87A 4uxqA-5m5pA:
undetectable		 4uxqA-5m5pA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1403
ALA A1674
PHE A1673
 None
 0.64A 4v1fA-5m5pA:
undetectable		 4v1fA-5m5pA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1403
ALA A1674
PHE A1673
 None
 0.60A 4v1fC-5m5pA:
undetectable		 4v1fC-5m5pA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 764
LYS A 760
ASN A 765
 None
 1.09A 4y1dA-5m5pA:
undetectable
4y1dD-5m5pA:
undetectable		 4y1dA-5m5pA:
7.27
4y1dD-5m5pA:
0.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 6 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.09A 4z4cA-5m5pA:
2.3		 4z4cA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.10A 4z4dA-5m5pA:
undetectable		 4z4dA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.20A 4z4hA-5m5pA:
undetectable		 4z4hA-5m5pA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5eeuA-5m5pA:
undetectable
5eeuB-5m5pA:
undetectable		 5eeuA-5m5pA:
3.64
5eeuB-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 5eeuC-5m5pA:
undetectable
5eeuD-5m5pA:
undetectable		 5eeuC-5m5pA:
3.64
5eeuD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5eeuE-5m5pA:
undetectable
5eeuF-5m5pA:
undetectable		 5eeuE-5m5pA:
3.64
5eeuF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 5eevC-5m5pA:
undetectable
5eevD-5m5pA:
undetectable		 5eevC-5m5pA:
3.64
5eevD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5eevE-5m5pA:
undetectable
5eevF-5m5pA:
undetectable		 5eevE-5m5pA:
3.64
5eevF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5eevH-5m5pA:
undetectable
5eevI-5m5pA:
undetectable		 5eevH-5m5pA:
3.64
5eevI-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 5eevA-5m5pA:
undetectable
5eevK-5m5pA:
undetectable		 5eevA-5m5pA:
3.64
5eevK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 5eewC-5m5pA:
undetectable
5eewD-5m5pA:
undetectable		 5eewC-5m5pA:
3.64
5eewD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5eewE-5m5pA:
undetectable
5eewF-5m5pA:
undetectable		 5eewE-5m5pA:
3.64
5eewF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 5eewA-5m5pA:
undetectable
5eewK-5m5pA:
undetectable		 5eewA-5m5pA:
3.64
5eewK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 5eexC-5m5pA:
undetectable
5eexD-5m5pA:
undetectable		 5eexC-5m5pA:
3.64
5eexD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5eexE-5m5pA:
undetectable
5eexF-5m5pA:
undetectable		 5eexE-5m5pA:
3.64
5eexF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 5eeyC-5m5pA:
undetectable
5eeyD-5m5pA:
undetectable		 5eeyC-5m5pA:
3.64
5eeyD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5eeyE-5m5pA:
undetectable
5eeyF-5m5pA:
undetectable		 5eeyE-5m5pA:
3.64
5eeyF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5eeyH-5m5pA:
undetectable
5eeyI-5m5pA:
undetectable		 5eeyH-5m5pA:
3.64
5eeyI-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 5eeyA-5m5pA:
undetectable
5eeyK-5m5pA:
undetectable		 5eeyA-5m5pA:
3.64
5eeyK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 5eezC-5m5pA:
undetectable
5eezD-5m5pA:
undetectable		 5eezC-5m5pA:
3.64
5eezD-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5eezE-5m5pA:
undetectable
5eezF-5m5pA:
undetectable		 5eezE-5m5pA:
3.64
5eezF-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5eezH-5m5pA:
undetectable
5eezI-5m5pA:
undetectable		 5eezH-5m5pA:
3.64
5eezI-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5eezJ-5m5pA:
undetectable
5eezK-5m5pA:
undetectable		 5eezJ-5m5pA:
3.64
5eezK-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 5ef0C-5m5pA:
undetectable
5ef0D-5m5pA:
undetectable		 5ef0C-5m5pA:
3.64
5ef0D-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5ef0E-5m5pA:
undetectable
5ef0F-5m5pA:
undetectable		 5ef0E-5m5pA:
3.64
5ef0F-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5ef0H-5m5pA:
undetectable
5ef0I-5m5pA:
undetectable		 5ef0H-5m5pA:
3.64
5ef0I-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5ef0J-5m5pA:
undetectable
5ef0K-5m5pA:
undetectable		 5ef0J-5m5pA:
3.64
5ef0K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.50A 5ef1C-5m5pA:
undetectable
5ef1D-5m5pA:
undetectable		 5ef1C-5m5pA:
3.64
5ef1D-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5ef1E-5m5pA:
undetectable
5ef1F-5m5pA:
undetectable		 5ef1E-5m5pA:
3.64
5ef1F-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5ef1H-5m5pA:
undetectable
5ef1I-5m5pA:
undetectable		 5ef1H-5m5pA:
3.64
5ef1I-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5ef1J-5m5pA:
undetectable
5ef1K-5m5pA:
undetectable		 5ef1J-5m5pA:
3.64
5ef1K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 5ef1A-5m5pA:
undetectable
5ef1K-5m5pA:
undetectable		 5ef1A-5m5pA:
3.64
5ef1K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 5ef2C-5m5pA:
undetectable
5ef2D-5m5pA:
undetectable		 5ef2C-5m5pA:
3.64
5ef2D-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5ef2E-5m5pA:
undetectable
5ef2F-5m5pA:
undetectable		 5ef2E-5m5pA:
3.64
5ef2F-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5ef2H-5m5pA:
undetectable
5ef2I-5m5pA:
undetectable		 5ef2H-5m5pA:
3.64
5ef2I-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5ef2J-5m5pA:
undetectable
5ef2K-5m5pA:
undetectable		 5ef2J-5m5pA:
3.64
5ef2K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 802
HIS A 805
THR A 803
ILE A 801
SER A 792
 None
 1.50A 5ef2A-5m5pA:
undetectable
5ef2K-5m5pA:
undetectable		 5ef2A-5m5pA:
3.64
5ef2K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.49A 5ef3C-5m5pA:
undetectable
5ef3D-5m5pA:
undetectable		 5ef3C-5m5pA:
3.64
5ef3D-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.46A 5ef3E-5m5pA:
undetectable
5ef3F-5m5pA:
undetectable		 5ef3E-5m5pA:
3.64
5ef3F-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.48A 5ef3H-5m5pA:
undetectable
5ef3I-5m5pA:
undetectable		 5ef3H-5m5pA:
3.64
5ef3I-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 SER A 792
GLY A 802
HIS A 805
THR A 803
ILE A 801
 None
 1.47A 5ef3J-5m5pA:
undetectable
5ef3K-5m5pA:
undetectable		 5ef3J-5m5pA:
3.64
5ef3K-5m5pA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 559
ASP A 634
PHE A 574
VAL A 535
ILE A 519
 None
 1.21A 5hw8B-5m5pA:
undetectable		 5hw8B-5m5pA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1515
TYR A1777
SER A1480
 None
 0.61A 5iktA-5m5pA:
undetectable		 5iktA-5m5pA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.17A 5js1A-5m5pA:
undetectable		 5js1A-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1841
ASP A1824
ILE A1763
 None
 0.63A 5kc4E-5m5pA:
1.9		 5kc4E-5m5pA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1951
LYS A2090
LEU A1947
TYR A1933
 None
 1.47A 5ki6A-5m5pA:
undetectable		 5ki6A-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1472
ILE A1398
PHE A1452
ILE A1498
ALA A1499
 None
 1.03A 5vceA-5m5pA:
undetectable		 5vceA-5m5pA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		6 / 9 LEU A 630
VAL A 535
ILE A 668
GLY A 669
LEU A 670
PHE A 491
 None
 1.42A 5vkqC-5m5pA:
undetectable
5vkqD-5m5pA:
undetectable		 5vkqC-5m5pA:
22.81
5vkqD-5m5pA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 9 PHE A1598
GLY A1636
VAL A1663
GLY A1638
LEU A1665
 None
 1.09A 5wm2A-5m5pA:
undetectable		 5wm2A-5m5pA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1507
PHE A1367
LEU A1359
 None
 0.66A 5x1bC-5m5pA:
undetectable		 5x1bC-5m5pA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A1684
LEU A1723
SER A1562
PHE A1559
 None
 0.92A 5xu8A-5m5pA:
undetectable		 5xu8A-5m5pA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 824
GLY A 823
LEU A 731
VAL A 730
ILE A 740
 None
 1.07A 6bxmA-5m5pA:
2.2		 6bxmA-5m5pA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A1193
LYS A1197
LEU A1173
GLU A1174
 None
 1.06A 6cbdA-5m5pA:
2.2		 6cbdA-5m5pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 10 MET A1471
LEU A1446
ALA A1447
ILE A1465
LEU A1491
 None
 1.32A 6cbzB-5m5pA:
undetectable		 6cbzB-5m5pA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1895
ARG A1588
ASP A1942
 None
 0.98A 6d8pA-5m5pA:
undetectable		 6d8pA-5m5pA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1858
SER A1859
THR A1862
ALA A1886
VAL A1483
 None
 1.42A 6drxA-5m5pA:
undetectable		 6drxA-5m5pA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5m5p PRE-MRNA-SPLICING
HELICASE BRR2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1465
LEU A1468
THR A1490
LEU A1491
 None
 0.84A 6nmpN-5m5pA:
undetectable
6nmpW-5m5pA:
undetectable		 6nmpN-5m5pA:
13.20
6nmpW-5m5pA:
2.80