SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 11 ILE A 473
ASP A 506
GLY A 467
PHE A 446
VAL A 538
 None
 1.16A 1axwB-5m60A:
undetectable		 1axwB-5m60A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 8 LEU A 535
ARG A 501
GLY A 500
TRP A 523
 None
 1.06A 1fapB-5m60A:
undetectable		 1fapB-5m60A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 421
GLY A 449
ILE A 473
ALA A 419
VAL A 414
 None
 0.94A 1jg2A-5m60A:
undetectable		 1jg2A-5m60A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 ILE A 443
ILE A 453
ILE A 431
VAL A 414
ILE A 463
 None
 1.04A 1r5lA-5m60A:
undetectable		 1r5lA-5m60A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 GLY A 510
ILE A 542
VAL A 490
SER A 572
 None
 1.18A 1rs7A-5m60A:
undetectable		 1rs7A-5m60A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 ALA A 430
TYR A 451
ILE A 431
ASP A 447
 None
 1.12A 1upfC-5m60A:
undetectable		 1upfC-5m60A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		3 / 3 ARG A 360
SER A 715
TYR A 714
 None
 0.77A 1x70A-5m60A:
undetectable		 1x70A-5m60A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 627
LEU A 535
GLY A 534
ARG A 398
PRO A 622
 None
 1.25A 1y4lA-5m60A:
undetectable		 1y4lA-5m60A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 LEU A  99
PRO A 471
ALA A 469
ILE A  55
 None
 1.01A 2aofB-5m60A:
undetectable		 2aofB-5m60A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 SER A 703
SER A 741
VAL A 743
LEU A 713
 None
 1.01A 2hdnE-5m60A:
undetectable
2hdnF-5m60A:
undetectable
2hdnH-5m60A:
undetectable		 2hdnE-5m60A:
4.17
2hdnF-5m60A:
17.96
2hdnH-5m60A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 SER A 741
VAL A 743
LEU A 713
SER A 703
 None
 1.04A 2hdnF-5m60A:
undetectable
2hdnG-5m60A:
undetectable
2hdnH-5m60A:
undetectable		 2hdnF-5m60A:
17.96
2hdnG-5m60A:
4.17
2hdnH-5m60A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		3 / 3 TYR A 234
GLY A 213
PHE A 237
 None
 0.64A 2m2pB-5m60A:
undetectable		 2m2pB-5m60A:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 9 SER A 741
ILE A 708
THR A 628
VAL A 698
VAL A 615
 None
 1.13A 2nnhB-5m60A:
undetectable		 2nnhB-5m60A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 PHE A 162
PHE A 163
TRP A 590
GLY A 543
 BGC  A 901 (-4.9A)
None
None
None
 1.40A 2qmzA-5m60A:
undetectable
2qmzB-5m60A:
undetectable		 2qmzA-5m60A:
15.38
2qmzB-5m60A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 PHE A 162
PHE A 163
TRP A 590
GLY A 544
 BGC  A 901 (-4.9A)
None
None
None
 1.37A 2qmzA-5m60A:
undetectable
2qmzB-5m60A:
undetectable		 2qmzA-5m60A:
15.38
2qmzB-5m60A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		3 / 3 GLN A 195
THR A 244
TRP A 626
 None
 1.08A 2rctA-5m60A:
undetectable		 2rctA-5m60A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 ILE A 473
LEU A 474
GLY A 423
GLY A 449
 None
 0.81A 2wd9A-5m60A:
2.1		 2wd9A-5m60A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLN A 659
THR A 655
PHE A 610
ASN A 719
GLY A 660
 None
 1.42A 3aobC-5m60A:
undetectable		 3aobC-5m60A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 11 LEU A 474
GLY A 510
ILE A 542
SER A 572
PRO A 516
 None
 1.34A 3bjwE-5m60A:
undetectable		 3bjwE-5m60A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 ALA A 419
ILE A 434
ILE A 465
LEU A 507
ILE A 473
 None
 1.04A 3clbC-5m60A:
undetectable		 3clbC-5m60A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 LEU A 474
GLY A 513
GLN A 549
VAL A 490
PHE A 481
 None
 1.35A 3gn8B-5m60A:
undetectable		 3gn8B-5m60A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 ALA A  64
PHE A 102
SER A  81
ILE A  80
LEU A 121
 None
 1.27A 3ia4C-5m60A:
undetectable		 3ia4C-5m60A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 ILE A 542
GLY A 543
GLY A 544
ALA A 597
VAL A 609
 None
 0.97A 3jb2A-5m60A:
undetectable		 3jb2A-5m60A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 PHE A 509
MET A 521
VAL A 493
PRO A 471
ILE A 453
 None
 1.48A 3p6gA-5m60A:
undetectable		 3p6gA-5m60A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 VAL A 328
LEU A 296
VAL A 347
GLY A 349
ALA A 336
 None
 1.29A 3pghA-5m60A:
undetectable		 3pghA-5m60A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 183
ASP A 172
GLY A 213
PHE A 229
MET A 201
 None
 1.08A 3ps9A-5m60A:
undetectable		 3ps9A-5m60A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 TYR A 657
ASN A 160
TYR A 545
TYR A 117
 NA  A 906 ( 4.6A)
BGC  A 901 (-3.0A)
None
None
 1.15A 3ugrA-5m60A:
undetectable		 3ugrA-5m60A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 4 ASN A 262
ALA A 264
GLY A 292
THR A 322
 None
 1.23A 4bboC-5m60A:
undetectable		 4bboC-5m60A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.03A 4fp9A-5m60A:
undetectable		 4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.85A 4fp9A-5m60A:
undetectable		 4fp9A-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.02A 4fp9C-5m60A:
undetectable		 4fp9C-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.85A 4fp9C-5m60A:
undetectable		 4fp9C-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.03A 4fp9D-5m60A:
undetectable		 4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.86A 4fp9D-5m60A:
undetectable		 4fp9D-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
ASN A 611
LEU A 574
GLY A 612
PRO A 487
 None
 1.03A 4fp9F-5m60A:
undetectable		 4fp9F-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 476
GLY A 477
LEU A 574
GLY A 612
PRO A 487
 None
 0.86A 4fp9F-5m60A:
undetectable		 4fp9F-5m60A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 TYR A 591
LEU A 586
ALA A 643
VAL A 646
GLY A 621
 None
 0.94A 4hfpD-5m60A:
undetectable		 4hfpD-5m60A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 ARG A 246
ASP A 389
GLY A 531
GLU A 529
 None
 0.94A 4koeA-5m60A:
undetectable
4koeB-5m60A:
undetectable
4koeD-5m60A:
undetectable		 4koeA-5m60A:
20.25
4koeB-5m60A:
20.25
4koeD-5m60A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		6 / 12 PHE A 267
GLY A 235
GLY A 213
LEU A 248
ARG A 233
ILE A 279
 None
 1.48A 4krhA-5m60A:
undetectable		 4krhA-5m60A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		6 / 12 PHE A 267
GLY A 235
GLY A 213
LEU A 248
ARG A 233
ILE A 279
 None
 1.45A 4krhB-5m60A:
undetectable		 4krhB-5m60A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 PHE A 647
LEU A 297
ASP A 298
ASP A 326
 None
 1.07A 4mmcA-5m60A:
undetectable		 4mmcA-5m60A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 10 VAL A 735
LEU A 745
ALA A 700
SER A 741
LEU A 737
 None
 1.06A 4ph9A-5m60A:
undetectable		 4ph9A-5m60A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 10 VAL A 735
LEU A 745
ALA A 700
SER A 741
LEU A 737
 None
 1.04A 4ph9B-5m60A:
undetectable		 4ph9B-5m60A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 8 TYR A 118
PHE A 163
GLY A 543
ILE A 607
 None
 1.00A 4qoiA-5m60A:
undetectable
4qoiB-5m60A:
undetectable		 4qoiA-5m60A:
15.36
4qoiB-5m60A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 4 ALA A 776
VAL A 778
GLY A 359
THR A 322
 None
 0.99A 4ubeA-5m60A:
undetectable		 4ubeA-5m60A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 6 PHE A 668
ASN A 563
PRO A 662
ARG A 613
 None
 1.12A 4yv5B-5m60A:
undetectable		 4yv5B-5m60A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 6 PHE A 668
ASN A 563
PRO A 662
ARG A 613
 None
 1.13A 4yv5A-5m60A:
undetectable		 4yv5A-5m60A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 ARG A 246
ASP A 389
GLY A 531
GLU A 529
 None
 0.93A 4z53A-5m60A:
undetectable
4z53B-5m60A:
undetectable		 4z53A-5m60A:
21.87
4z53B-5m60A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 288
LEU A 323
ILE A 353
GLY A 307
MET A 281
 NAG  A 905 (-3.5A)
None
None
None
None
 1.09A 5eskA-5m60A:
undetectable		 5eskA-5m60A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 288
ILE A 353
GLY A 307
THR A 290
MET A 281
 NAG  A 905 (-3.5A)
None
None
None
None
 1.26A 5eslA-5m60A:
undetectable		 5eslA-5m60A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 SER A  92
ASN A 218
GLN A 159
ASP A 217
 None
 1.09A 5kpcA-5m60A:
undetectable		 5kpcA-5m60A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 12 PHE A 229
ALA A 236
ILE A 184
SER A 182
ILE A 257
 None
 0.98A 5m24A-5m60A:
undetectable		 5m24A-5m60A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 7 PHE A 267
ALA A 256
GLY A 235
TYR A 234
 None
 1.05A 5uxdA-5m60A:
undetectable		 5uxdA-5m60A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 5 ASN A 218
ASP A 217
ASP A 144
ASN A 161
 None
 1.43A 5vooE-5m60A:
undetectable		 5vooE-5m60A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 6 GLY A 697
SER A 715
THR A 750
VAL A 735
 None
 1.14A 5ysiA-5m60A:
undetectable		 5ysiA-5m60A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 8 VAL A 294
ILE A 308
THR A 310
TYR A 312
 None
 0.93A 6cduG-5m60A:
undetectable
6cduH-5m60A:
undetectable		 6cduG-5m60A:
18.60
6cduH-5m60A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 10 GLY A 534
LEU A 535
VAL A 623
VAL A 615
LEU A 576
 None
 0.95A 6czmA-5m60A:
undetectable
6czmC-5m60A:
undetectable		 6czmA-5m60A:
20.08
6czmC-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 9 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.96A 6czmA-5m60A:
undetectable
6czmB-5m60A:
undetectable		 6czmA-5m60A:
20.08
6czmB-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 9 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.94A 6czmB-5m60A:
undetectable
6czmC-5m60A:
undetectable		 6czmB-5m60A:
20.08
6czmC-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 9 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.97A 6czmD-5m60A:
undetectable
6czmE-5m60A:
undetectable		 6czmD-5m60A:
20.08
6czmE-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		5 / 10 VAL A 615
LEU A 576
GLY A 534
LEU A 535
VAL A 623
 None
 0.94A 6czmE-5m60A:
undetectable
6czmF-5m60A:
undetectable		 6czmE-5m60A:
20.08
6czmF-5m60A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5m60 BETA-1,3-GLUCANASE
(Chaetomium
thermophilum) 		4 / 6 GLU A 568
LYS A 566
PHE A 570
VAL A 609
 None
 1.45A 6fgdA-5m60A:
undetectable		 6fgdA-5m60A:
20.53