SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 12 ASN L  54
ILE L  72
PHE L  95
GLY L  88
THR L  98
 BGC  L 303 ( 4.7A)
None
None
None
None
 1.48A 1g60B-5m63L:
undetectable		 1g60B-5m63L:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5m63 H CHAIN OF FAB
NVS-1-19-5
L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		6 / 12 TYR L  60
TYR H  78
PHE L 125
VAL H  55
ALA H 115
TRP H 134
 None
 0.90A 1h8sA-5m63L:
20.3		 1h8sA-5m63L:
32.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_A_VIBA702_1
(THIAMIN
PYROPHOSPHOKINASE)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 9 TYR L 166
VAL L 222
SER L 203
SER L 188
ASN L 187
 None
 1.31A 2hh9A-5m63L:
0.0
2hh9B-5m63L:
0.0		 2hh9A-5m63L:
21.39
2hh9B-5m63L:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_B_VIBB701_1
(THIAMIN
PYROPHOSPHOKINASE)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 9 VAL L 222
SER L 203
SER L 188
ASN L 187
TYR L 166
 None
 1.30A 2hh9A-5m63L:
0.0
2hh9B-5m63L:
0.0		 2hh9A-5m63L:
21.39
2hh9B-5m63L:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5m63 H CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 12 VAL H 194
VAL H 213
SER H 211
ASN H 225
ASN H 186
 None
 1.45A 2y03A-5m63H:
undetectable		 2y03A-5m63H:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m63 H CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		3 / 3 THR H 109
GLU H 179
HIS H 228
 None
 0.81A 3g1uB-5m63H:
undetectable		 3g1uB-5m63H:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m63 H CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		4 / 5 LEU H 139
GLN H  57
THR H 111
GLU H 179
 None
EDO  L 309 ( 4.1A)
None
None
 1.22A 3n58C-5m63H:
undetectable		 3n58C-5m63H:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5m63 H CHAIN OF FAB
NVS-1-19-5
L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		4 / 7 THR L 123
TRP H  65
HIS H 127
ASN L 118
 None
None
SIA  H 306 ( 3.7A)
None
 1.24A 4a3uA-5m63L:
undetectable		 4a3uA-5m63L:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		3 / 3 GLN L 181
THR L 180
THR L 179
 None
 0.82A 4fufA-5m63L:
undetectable		 4fufA-5m63L:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		3 / 3 SER L  34
ALA L  36
VAL L  37
 None
 0.38A 4o2bA-5m63L:
undetectable		 4o2bA-5m63L:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		3 / 3 SER L  34
ALA L  36
VAL L  37
 None
 0.51A 4x1iA-5m63L:
undetectable		 4x1iA-5m63L:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		4 / 5 VAL L  41
ILE L  43
VAL L 131
THR L 129
 None
 0.75A 4xdtA-5m63L:
undetectable		 4xdtA-5m63L:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		3 / 3 SER L  34
ALA L  36
VAL L  37
 None
 0.49A 5eypA-5m63L:
undetectable		 5eypA-5m63L:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5m63 H CHAIN OF FAB
NVS-1-19-5
L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		5 / 12 GLY L 114
GLY H 129
THR L 123
VAL L  24
LEU L  26
 None
 1.19A 5kocB-5m63L:
undetectable		 5kocB-5m63L:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5m63 H CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 12 GLY H 193
SER H 217
THR H 168
LEU H 169
VAL H 222
 None
 0.76A 5twjA-5m63H:
undetectable		 5twjA-5m63H:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		4 / 5 THR L 183
THR L 179
HIS L 215
LEU L 207
 None
 1.39A 6aphA-5m63L:
undetectable		 6aphA-5m63L:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 5m63 L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		4 / 4 VAL L  37
GLY L 135
ASP L 136
ASP L 196
 None
 0.87A 6cjkC-5m63L:
27.2		 6cjkC-5m63L:
76.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5m63 H CHAIN OF FAB
NVS-1-19-5
L CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		4 / 7 TYR L  60
CSS H  53
CSS H  68
TRP H 134
 None
 1.05A 6cnkB-5m63L:
2.4
6cnkC-5m63L:
undetectable		 6cnkB-5m63L:
15.29
6cnkC-5m63L:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5m63 H CHAIN OF FAB
NVS-1-19-5
(Oryctolagus
cuniculus) 		5 / 11 VAL H 235
THR H 233
VAL H 239
ALA H 149
VAL H 183
 None
 1.07A 6dryA-5m63H:
undetectable		 6dryA-5m63H:
20.90