SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 LEU A3462
THR A3459
LEU A3308
GLY A3450
PHE A3468
 None
 1.19A 1v8bA-5m6pA:
undetectable		 1v8bA-5m6pA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 LEU A3462
THR A3459
LEU A3308
GLY A3450
PHE A3468
 None
 1.22A 1v8bB-5m6pA:
undetectable		 1v8bB-5m6pA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 HIS A3174
ARG A3409
GLN A3119
ASP A3175
LEU A3177
 None
 1.30A 2a5hB-5m6pA:
undetectable		 2a5hB-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 HIS A3174
ARG A3409
GLN A3119
ASP A3175
LEU A3177
 None
 1.29A 2a5hC-5m6pA:
undetectable		 2a5hC-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 HIS A3174
ARG A3409
GLN A3119
ASP A3175
LEU A3177
 None
 1.30A 2a5hD-5m6pA:
undetectable		 2a5hD-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 ASP A3247
ASP A3159
ASP A3206
 None
 0.70A 2igtA-5m6pA:
undetectable		 2igtA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 ASP A3290
THR A3129
PRO A3130
 None
 0.35A 2q64B-5m6pA:
undetectable		 2q64B-5m6pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 7 GLN A3132
PHE A3135
ARG A3143
HIS A3254
 None
 1.13A 2qmqA-5m6pA:
undetectable		 2qmqA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 LEU A3511
LEU A3550
ILE A3525
ILE A3553
VAL A3389
 None
 1.10A 2ygnA-5m6pA:
undetectable		 2ygnA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 GLY A3528
SER A3515
ALA A3516
LEU A3393
ILE A3474
 None
 1.31A 3adsB-5m6pA:
undetectable		 3adsB-5m6pA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.94A 3aicA-5m6pA:
undetectable		 3aicA-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.91A 3aicB-5m6pA:
undetectable		 3aicB-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.89A 3aicE-5m6pA:
undetectable		 3aicE-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.85A 3aicF-5m6pA:
undetectable		 3aicF-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.90A 3aicG-5m6pA:
undetectable		 3aicG-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 LEU A3457
TRP A3315
TYR A3302
 None
 0.88A 3aicH-5m6pA:
undetectable		 3aicH-5m6pA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 VAL A3389
LEU A3441
LEU A3393
SER A3475
THR A3374
 None
 1.23A 3hj3C-5m6pA:
undetectable		 3hj3C-5m6pA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 9 GLY A3377
ALA A3379
ASP A3382
ILE A3553
ILE A3525
 None
 0.91A 3s53A-5m6pA:
undetectable		 3s53A-5m6pA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 5 SER A3475
PRO A3419
TYR A3418
VAL A3390
 None
 1.34A 3sufC-5m6pA:
undetectable		 3sufC-5m6pA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		3 / 3 ASP A3290
THR A3129
PRO A3130
 None
 0.36A 3tkgD-5m6pA:
undetectable		 3tkgD-5m6pA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 LEU A3220
PHE A3241
TYR A3203
ALA A3252
GLY A3497
 None
 1.43A 4j7xA-5m6pA:
undetectable		 4j7xA-5m6pA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		5 / 12 LEU A3550
LEU A3551
GLY A3552
THR A3374
ILE A3434
 None
 1.26A 4oktA-5m6pA:
undetectable		 4oktA-5m6pA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 6 ILE A3453
LYS A3446
LEU A3308
GLU A3307
 None
 0.82A 4w5nA-5m6pA:
undetectable		 4w5nA-5m6pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 5 ALA A3297
HIS A3255
PRO A3130
PHE A3414
 None
 1.38A 4ze2A-5m6pA:
1.3		 4ze2A-5m6pA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 5 SER A3526
GLY A3497
GLU A3214
ARG A3524
 None
 1.03A 5cdqA-5m6pA:
2.8
5cdqB-5m6pA:
undetectable
5cdqC-5m6pA:
2.7		 5cdqA-5m6pA:
10.22
5cdqB-5m6pA:
13.99
5cdqC-5m6pA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 5 SER A3526
GLY A3497
GLU A3214
ARG A3524
 None
 1.18A 5cdqR-5m6pA:
undetectable
5cdqS-5m6pA:
undetectable
5cdqT-5m6pA:
2.4		 5cdqR-5m6pA:
10.22
5cdqS-5m6pA:
13.99
5cdqT-5m6pA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5m6p TYROCIDINE SYNTHASE
2
(Brevibacillus
parabrevis) 		4 / 7 VAL A3251
VAL A3236
PHE A3200
ILE A3170
 None
 0.90A 5yf9B-5m6pA:
undetectable		 5yf9B-5m6pA:
16.87