SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 383
ASP A 378
ASP A 560
 None
 0.78A 1ej0A-5m6uA:
undetectable		 1ej0A-5m6uA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 6 LEU A 613
LEU A 977
LEU A 989
LEU A 800
 None
 0.90A 1errA-5m6uA:
undetectable		 1errA-5m6uA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 6 PRO A 385
MET A 387
ASP A 430
TYR A 485
 None
 1.45A 2lh8A-5m6uA:
1.7		 2lh8A-5m6uA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 7 LEU A 613
VAL A 884
ILE A 794
ARG A 968
 None
 1.28A 3ik3A-5m6uA:
undetectable		 3ik3A-5m6uA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLU B 485
ALA B 483
ASP B 548
LEU B 545
ALA A  77
 None
 1.29A 3ou6C-5m6uB:
undetectable		 3ou6C-5m6uB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		3 / 3 ASN A 556
ASP A 560
ASP A 529
 None
 0.67A 4obwD-5m6uA:
undetectable		 4obwD-5m6uA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		9 / 12 MET A 752
PRO A 758
TRP A 760
TYR A 813
VAL A 828
ASP A 832
THR A 833
MET A 900
ILE A 910
 7KA  A1101 ( 4.5A)
7KA  A1101 (-4.3A)
None
7KA  A1101 (-3.5A)
7KA  A1101 (-4.1A)
7KA  A1101 (-3.7A)
7KA  A1101 ( 4.4A)
7KA  A1101 (-3.6A)
7KA  A1101 (-3.7A)
 0.36A 4xe0A-5m6uA:
50.1		 4xe0A-5m6uA:
94.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		5 / 12 PRO A 817
THR A 818
TRP A 649
PHE A 778
GLY A 686
 None
 1.38A 4ydqB-5m6uA:
undetectable		 4ydqB-5m6uA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 7 ALA A 885
ASP A 807
ARG A 809
GLU A 874
 None
 0.76A 5bs8A-5m6uA:
undetectable
5bs8B-5m6uA:
undetectable
5bs8C-5m6uA:
undetectable		 5bs8A-5m6uA:
19.53
5bs8B-5m6uA:
13.82
5bs8C-5m6uA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 7 ALA A 885
ASP A 807
ARG A 809
GLU A 874
 None
 0.74A 5btdA-5m6uA:
1.1
5btdB-5m6uA:
undetectable
5btdC-5m6uA:
undetectable		 5btdA-5m6uA:
19.53
5btdB-5m6uA:
13.82
5btdC-5m6uA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 7 ALA A 885
ASP A 807
ARG A 809
GLU A 874
 None
 0.71A 5btdA-5m6uA:
1.3
5btdC-5m6uA:
undetectable
5btdD-5m6uA:
undetectable		 5btdA-5m6uA:
19.53
5btdC-5m6uA:
19.53
5btdD-5m6uA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 6 PHE A 932
PRO A 931
THR A 886
ILE A 933
 None
 1.39A 5ih0A-5m6uA:
6.1		 5ih0A-5m6uA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_0
(REGULATORY PROTEIN
TETR)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA B 486
GLU B 495
ARG A 100
VAL A  98
PHE B 494
 None
 1.38A 5vlmH-5m6uB:
undetectable		 5vlmH-5m6uB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM
(Homo
sapiens) 		4 / 5 ASN A 640
TYR A 254
GLY A 252
ASP A 606
 None
 1.28A 6gh9A-5m6uA:
undetectable		 6gh9A-5m6uA:
7.00