SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 7 LEU A 135
ALA A 133
LEU A 181
THR A 184
 None
 1.08A 1dvxA-5m76A:
undetectable		 1dvxA-5m76A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 8 SER A 182
TYR A 180
SER A 179
THR A 164
 None
 1.08A 2v0zO-5m76A:
undetectable		 2v0zO-5m76A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 7 SER A 190
HIS A 191
THR A 184
LEU A 183
 None
 1.22A 3arrA-5m76A:
6.8		 3arrA-5m76A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 7 VAL A 108
ARG A  61
VAL A  18
GLU A  83
 None
 1.14A 3jx2A-5m76A:
undetectable
3jx2B-5m76A:
undetectable		 3jx2A-5m76A:
21.27
3jx2B-5m76A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 7 VAL A 108
ARG A  61
VAL A  18
GLU A  83
 None
 1.19A 3jx3A-5m76A:
undetectable
3jx3B-5m76A:
undetectable		 3jx3A-5m76A:
21.27
3jx3B-5m76A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 7 VAL A 108
ARG A  61
VAL A  18
GLU A  83
 None
 1.16A 3jx5A-5m76A:
undetectable
3jx5B-5m76A:
undetectable		 3jx5A-5m76A:
21.27
3jx5B-5m76A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.96A 4k8cA-5m76A:
undetectable		 4k8cA-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.95A 4kahA-5m76A:
undetectable		 4kahA-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.96A 4kahB-5m76A:
undetectable		 4kahB-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.93A 4kanA-5m76A:
undetectable		 4kanA-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.96A 4kanB-5m76A:
undetectable		 4kanB-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.97A 4kbeA-5m76A:
undetectable		 4kbeA-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.97A 4lbgA-5m76A:
undetectable		 4lbgA-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		3 / 3 SER A 178
TYR A 180
PRO A 167
 None
 0.95A 4lbgB-5m76A:
undetectable		 4lbgB-5m76A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_C_MMZC503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 4 TYR A  32
ASN A  25
SER A  94
SER A  93
 None
 1.46A 5gsnC-5m76A:
undetectable		 5gsnC-5m76A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5m76 LIGHT CHAIN DIMER
(Homo
sapiens) 		4 / 6 LEU A 135
ALA A 133
LEU A 181
THR A 184
 None
 1.03A 5l4iB-5m76A:
4.2		 5l4iB-5m76A:
23.00