SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 4 VAL A  74
TRP A  79
TRP A 128
 None
 1.07A 1gmkA-5m77A:
undetectable
1gmkB-5m77A:
undetectable		 1gmkA-5m77A:
2.97
1gmkB-5m77A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 11 ALA A 258
LEU A 255
LEU A 193
ILE A 211
ALA A 207
 None
None
EDO  A 605 ( 4.0A)
None
None
 1.07A 1ha2A-5m77A:
undetectable		 1ha2A-5m77A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 GLU A  77
GLY A 246
ASP A  84
ILE A 139
GLY A 132
 None
None
None
EDO  A 603 ( 4.4A)
None
 1.21A 1q8jB-5m77A:
undetectable		 1q8jB-5m77A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 5 PRO A 187
GLY A 246
ASN A 305
GLY A 250
 None
None
None
EDO  A 605 (-3.5A)
 1.09A 1zlqA-5m77A:
undetectable		 1zlqA-5m77A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 LEU A  81
ASN A  49
PHE A  48
VAL A 105
GLN A 101
 None
EDO  A 602 (-3.9A)
None
None
EDO  A 602 ( 3.7A)
 1.17A 2xpwA-5m77A:
undetectable		 2xpwA-5m77A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 VAL A 369
ASN A  49
TRP A  53
 None
EDO  A 602 (-3.9A)
EDO  A 602 ( 4.7A)
 1.00A 2y00B-5m77A:
undetectable		 2y00B-5m77A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 ARG A 304
MET A 131
ARG A 135
 None
None
EDO  A 601 (-4.0A)
 1.44A 3uvvA-5m77A:
undetectable		 3uvvA-5m77A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 LEU A  81
ASN A  49
PHE A  48
VAL A 105
GLN A 101
 None
EDO  A 602 (-3.9A)
None
None
EDO  A 602 ( 3.7A)
 1.17A 4b3aA-5m77A:
undetectable		 4b3aA-5m77A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 8 TRP A 128
ASN A 305
GLY A 250
SER A 251
 None
None
EDO  A 605 (-3.5A)
None
 0.74A 4f93B-5m77A:
undetectable		 4f93B-5m77A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 5 TYR A 243
ASP A  71
GLU A  77
VAL A 105
 7K2  A 607 (-4.7A)
None
None
None
 1.26A 4nkvA-5m77A:
undetectable		 4nkvA-5m77A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 5 TYR A 243
ASP A  71
GLU A  77
VAL A 105
 7K2  A 607 (-4.7A)
None
None
None
 1.27A 4nkvB-5m77A:
undetectable		 4nkvB-5m77A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 8 ASP A 158
TYR A 204
ASP A 154
ILE A 211
 None
 1.05A 5cfsA-5m77A:
undetectable		 5cfsA-5m77A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 10 VAL A 253
GLY A 254
ALA A 268
LEU A 265
ASN A 261
 None
EDO  A 605 (-3.5A)
None
None
None
 1.21A 5x6yB-5m77A:
undetectable		 5x6yB-5m77A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5m77 ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
 None
None
EDO  A 605 ( 4.9A)
None
None
 1.01A 6djzC-5m77A:
undetectable		 6djzC-5m77A:
16.61