SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		3 / 3 SER A  83
GLY A  84
ARG A 111
 None
 0.68A 1t9wA-5m7oA:
undetectable		 1t9wA-5m7oA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 8 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.87A 1v54P-5m7oA:
undetectable
1v54W-5m7oA:
undetectable		 1v54P-5m7oA:
17.83
1v54W-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 7 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.90A 2eikC-5m7oA:
undetectable
2eikJ-5m7oA:
undetectable		 2eikC-5m7oA:
17.83
2eikJ-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 8 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.90A 2eilC-5m7oA:
undetectable
2eilJ-5m7oA:
undetectable		 2eilC-5m7oA:
17.83
2eilJ-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 7 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.95A 3ag2P-5m7oA:
undetectable
3ag2W-5m7oA:
undetectable		 3ag2P-5m7oA:
17.83
3ag2W-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 8 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.84A 3ag4C-5m7oA:
undetectable
3ag4J-5m7oA:
undetectable		 3ag4C-5m7oA:
17.83
3ag4J-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 7 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.86A 3ag4P-5m7oA:
undetectable
3ag4W-5m7oA:
undetectable		 3ag4P-5m7oA:
17.83
3ag4W-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 7 LEU A 358
GLN A 357
PHE A 323
LEU A 319
 None
 0.83A 3asnC-5m7oA:
undetectable
3asnJ-5m7oA:
undetectable		 3asnC-5m7oA:
17.83
3asnJ-5m7oA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		5 / 9 VAL A 268
PHE A 212
ALA A 225
VAL A 272
VAL A 253
 None
 1.24A 3me6D-5m7oA:
undetectable		 3me6D-5m7oA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 7 TYR A 235
VAL A 143
VAL A 306
ARG A 359
 None
 1.24A 3ms9B-5m7oA:
undetectable		 3ms9B-5m7oA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		5 / 9 ILE A 156
LEU A 152
VAL A 306
VAL A 143
LEU A 142
 None
 1.23A 4g1bC-5m7oA:
2.5		 4g1bC-5m7oA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 5 ILE A 338
LEU A 346
GLU A 321
VAL A 143
 None
 0.98A 4nkxB-5m7oA:
undetectable		 4nkxB-5m7oA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 6 LEU A 355
LEU A 142
VAL A 143
ARG A 312
 None
 1.26A 4uswA-5m7oA:
undetectable		 4uswA-5m7oA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 6 LEU A  67
LEU A  64
ILE A  54
MET A  81
 None
 0.89A 4ww7A-5m7oA:
undetectable		 4ww7A-5m7oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		4 / 6 LYS A 105
PHE A 102
VAL A   7
ASP A  53
 MG  A 501 (-3.6A)
None
None
MG  A 501 (-2.9A)
 1.02A 5hesA-5m7oA:
undetectable		 5hesA-5m7oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN
(Brucella
abortus) 		3 / 3 ARG A 261
LYS A 249
ARG A 221
 None
 1.36A 6az3C-5m7oA:
undetectable
6az3L-5m7oA:
undetectable
6az3M-5m7oA:
undetectable		 6az3C-5m7oA:
11.85
6az3L-5m7oA:
8.54
6az3M-5m7oA:
11.22