SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 VAL A 461
SER A 478
ARG A 453
LEU A 456
 None
 1.02A 2f78B-5m85A:
undetectable		 2f78B-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 VAL A 461
SER A 478
ARG A 453
LEU A 456
 None
 1.13A 2f8dA-5m85A:
undetectable		 2f8dA-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 441
PRO A 468
ASN A 467
LEU A 591
ARG A 594
 None
 1.37A 2ft9A-5m85A:
undetectable		 2ft9A-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 552
GLY A 583
GLY A 554
LEU A 555
HIS A 512
 None
 1.20A 3e23A-5m85A:
undetectable		 3e23A-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 583
VAL A 546
ILE A 444
GLN A 581
 None
 0.80A 3fi0P-5m85A:
undetectable		 3fi0P-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A 509
THR A 543
GLU A 513
 NA  A 703 ( 4.3A)
CYC  A 701 ( 4.0A)
None
 0.81A 4df3A-5m85A:
undetectable		 4df3A-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR A 509
THR A 543
GLU A 513
 NA  A 703 ( 4.3A)
CYC  A 701 ( 4.0A)
None
 0.77A 4df3B-5m85A:
undetectable		 4df3B-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ARG A 508
GLY A 507
PRO A 545
HIS A 576
 CYC  A 701 ( 3.7A)
None
None
None
 0.81A 4lajA-5m85A:
undetectable
4lajB-5m85A:
undetectable		 4lajA-5m85A:
10.34
4lajB-5m85A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 465
TRP A 553
ILE A 475
 None
 0.68A 4mwxA-5m85A:
undetectable		 4mwxA-5m85A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLU A 451
THR A 448
GLN A 581
THR A 543
 None
None
None
CYC  A 701 ( 4.0A)
 1.24A 4pfjB-5m85A:
undetectable		 4pfjB-5m85A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 LEU A 556
GLY A 557
SER A 478
VAL A 452
THR A 448
 None
 1.41A 4x3mA-5m85A:
undetectable		 4x3mA-5m85A:
14.22