SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 7 ARG A 277
ASN A 261
TYR A 214
ILE A 189
 CL  A 402 (-4.0A)
None
None
None
 1.32A 1tdnA-5m86A:
undetectable		 1tdnA-5m86A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 PHE A 190
TYR A 216
TYR A 214
 None
 1.01A 1x70B-5m86A:
undetectable		 1x70B-5m86A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 11 PHE A 255
ILE A 227
THR A 231
ALA A 232
TYR A 216
 None
 1.41A 2gl0B-5m86A:
undetectable
2gl0C-5m86A:
2.2		 2gl0B-5m86A:
20.66
2gl0C-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 ILE A 227
THR A 231
ALA A 232
TYR A 216
PHE A 255
 None
 1.46A 2gl0A-5m86A:
undetectable
2gl0C-5m86A:
2.2		 2gl0A-5m86A:
20.66
2gl0C-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 PHE A 255
ILE A 227
THR A 231
ALA A 232
TYR A 216
 None
 1.43A 2gl0D-5m86A:
2.3
2gl0E-5m86A:
undetectable		 2gl0D-5m86A:
20.66
2gl0E-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 11 PHE A 255
ILE A 227
THR A 231
ALA A 232
TYR A 216
 None
 1.43A 2gl0E-5m86A:
undetectable
2gl0F-5m86A:
2.2		 2gl0E-5m86A:
20.66
2gl0F-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 11 ILE A 227
THR A 231
ALA A 232
TYR A 216
PHE A 255
 None
 1.41A 2gl0D-5m86A:
2.3
2gl0F-5m86A:
2.2		 2gl0D-5m86A:
20.66
2gl0F-5m86A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 ARG A 277
SER A 203
TYR A 274
 CL  A 402 (-4.0A)
None
None
 1.06A 2q2hA-5m86A:
undetectable
2q2hB-5m86A:
undetectable		 2q2hA-5m86A:
17.54
2q2hB-5m86A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 4 ASP A  10
ASP A 161
SER A 163
ARG A 126
 None
 1.47A 2z0aC-5m86A:
undetectable		 2z0aC-5m86A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 7 MET A  40
PHE A  52
ILE A 149
ASN A 148
 None
 1.14A 2zseA-5m86A:
undetectable		 2zseA-5m86A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 THR A  91
ASN A  25
ILE A 149
VAL A 125
LEU A 123
 None
 1.27A 3a51B-5m86A:
undetectable		 3a51B-5m86A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 8 TYR A 214
LYS A 204
PRO A  42
PHE A  52
 None
 1.44A 3bjwD-5m86A:
undetectable		 3bjwD-5m86A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 PHE A  55
TYR A  88
LEU A  36
 GOL  A 403 (-3.4A)
None
None
 0.69A 3keeB-5m86A:
undetectable		 3keeB-5m86A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 8 GLU A 202
GLN A  16
ARG A 276
ASP A 112
 None
 0.97A 3mjrD-5m86A:
undetectable		 3mjrD-5m86A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 TYR A 273
LEU A  41
PRO A  42
SER A 264
LEU A 275
 None
None
None
None
GOL  A 403 ( 4.6A)
 1.24A 3okxA-5m86A:
undetectable		 3okxA-5m86A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 TYR A 273
LEU A  41
PRO A  42
SER A 264
LEU A 275
 None
None
None
None
GOL  A 403 ( 4.6A)
 1.27A 3okxB-5m86A:
undetectable		 3okxB-5m86A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 HIS A 245
SER A 108
ASN A 157
 None
 0.82A 3s8pB-5m86A:
undetectable		 3s8pB-5m86A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 PHE A  55
TYR A  88
LEU A  36
 GOL  A 403 (-3.4A)
None
None
 0.50A 3sueB-5m86A:
undetectable		 3sueB-5m86A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 12 ILE A 189
ALA A 191
ASP A 230
LYS A 237
TYR A 281
 None
 1.34A 4gh8B-5m86A:
undetectable		 4gh8B-5m86A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 11 PHE A  13
GLY A 159
GLY A  11
ILE A 227
LEU A 228
 None
 1.08A 4kt0A-5m86A:
undetectable
4kt0J-5m86A:
undetectable		 4kt0A-5m86A:
17.68
4kt0J-5m86A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 7 PHE A 190
ILE A 189
TYR A 216
ASN A 261
 None
 1.18A 4o7gA-5m86A:
undetectable
4o7gB-5m86A:
undetectable		 4o7gA-5m86A:
22.02
4o7gB-5m86A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5m86 TA1207
(Thermoplasma
acidophilum) 		3 / 3 HIS A 245
SER A 108
ASN A 157
 None
 0.85A 5cprB-5m86A:
undetectable		 5cprB-5m86A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		4 / 7 GLY A 235
PHE A 254
GLU A 236
ASN A 210
 None
 0.89A 5n5dB-5m86A:
undetectable		 5n5dB-5m86A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5m86 TA1207
(Thermoplasma
acidophilum) 		5 / 11 ALA A  17
ASP A  14
SER A  15
ILE A 215
ILE A   9
 None
 1.22A 5y80A-5m86A:
1.6		 5y80A-5m86A:
15.33