SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 6 SER A 303
ARG A 317
ARG A 314
TYR A 307
 None
 1.11A 1tufA-5m89A:
undetectable
1tufB-5m89A:
undetectable		 1tufA-5m89A:
13.11
1tufB-5m89A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 12 ALA A 247
VAL A 203
SER A 207
GLY A 258
ILE A 257
 None
 1.30A 3a65A-5m89A:
undetectable		 3a65A-5m89A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 12 LEU A 335
GLY A 333
GLN A 168
VAL A 167
ILE A 294
 None
 1.03A 3h52A-5m89A:
undetectable		 3h52A-5m89A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 12 GLY A 453
SER A 467
PRO A 450
GLY A 426
ASP A 210
 None
 1.50A 3r24A-5m89A:
undetectable		 3r24A-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 8 ARG A 462
TRP A 184
GLU A 214
GLU A 459
 None
 1.01A 4bqfB-5m89A:
undetectable		 4bqfB-5m89A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 5 ARG A 468
VAL A 218
LEU A 209
SER A 208
 None
 0.82A 4e1gA-5m89A:
undetectable		 4e1gA-5m89A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 5 GLY A 252
THR A 251
GLY A 292
GLU A 212
 None
 1.13A 4v20A-5m89A:
undetectable		 4v20A-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 10 GLY A 424
VAL A 451
VAL A 429
LEU A 209
LEU A 475
 None
 1.36A 4yb6C-5m89A:
undetectable
4yb6F-5m89A:
undetectable		 4yb6C-5m89A:
undetectable
4yb6F-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 5 GLU A 212
THR A 251
GLU A 249
LEU A 225
 None
 1.25A 5hm8G-5m89A:
undetectable		 5hm8G-5m89A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 5 TYR A 267
LYS A 265
GLU A 243
GLY A 242
 None
 1.46A 5jhdJ-5m89A:
undetectable		 5jhdJ-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 12 LEU A 201
ASP A 222
GLY A 220
LEU A 209
ALA A 216
 None
 1.25A 5kbwA-5m89A:
undetectable		 5kbwA-5m89A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		5 / 12 LEU A 201
ASP A 222
GLY A 220
LEU A 209
ALA A 216
 None
 1.34A 5kc4E-5m89A:
undetectable		 5kc4E-5m89A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		6 / 12 TYR A 267
GLY A 258
LEU A 286
GLN A 277
VAL A 264
LEU A 295
 None
 1.33A 5ubbA-5m89A:
undetectable		 5ubbA-5m89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5m89 SPLICEOSOME WD40 SC
(Chaetomium
thermophilum) 		4 / 7 GLN A 205
GLY A 220
ASP A 226
ASP A 240
 None
 0.91A 5vlmE-5m89A:
undetectable		 5vlmE-5m89A:
undetectable