SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 HIS A 283
GLY A 265
ASN A 267
GLY A 203
ASP A 141
 None
None
None
TRS  A 402 ( 4.3A)
TRS  A 402 (-3.0A)
 1.20A 1ffyA-5m8bA:
undetectable		 1ffyA-5m8bA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 ARG A 212
LEU A 215
VAL A 206
ALA A 147
PHE A 145
 None
 1.25A 1gseA-5m8bA:
undetectable		 1gseA-5m8bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKW_A_PNTA225_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 GLN A 157
TYR A 153
THR A 133
GLU A 132
TYR A  89
 PGE  A 404 (-2.9A)
None
PGE  A 404 ( 4.0A)
None
None
 1.39A 1rkwA-5m8bA:
undetectable		 1rkwA-5m8bA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		3 / 3 TRP A  86
THR A  31
TYR A  19
 None
 1.09A 2a3aB-5m8bA:
undetectable		 2a3aB-5m8bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 ARG A 209
PHE A 317
GLY A 318
VAL A 281
TYR A 282
 None
 1.18A 2nyrB-5m8bA:
undetectable		 2nyrB-5m8bA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		3 / 3 MET A 108
GLU A  78
ASN A 267
 None
MG  A 401 (-3.1A)
None
 1.10A 3a27A-5m8bA:
undetectable		 3a27A-5m8bA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 ASP A  17
ASP A 141
SER A 218
SER A 166
ALA A 156
 PGE  A 403 ( 2.9A)
TRS  A 402 (-3.0A)
None
None
None
 1.16A 3d91A-5m8bA:
undetectable		 3d91A-5m8bA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		4 / 7 TYR A 226
VAL A 200
ILE A 168
HIS A 283
 None
 1.17A 4xo7B-5m8bA:
undetectable		 4xo7B-5m8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		5 / 12 ALA A  36
VAL A  34
ALA A  69
ALA A  92
TYR A 109
 None
 1.08A 5n5dA-5m8bA:
undetectable		 5n5dA-5m8bA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5m8b ALPHA-L-ARABINOFURAN
OSIDASE II
(Lactobacillus
brevis) 		4 / 7 LEU A 140
PHE A 138
ILE A 162
ASN A 201
 TRS  A 402 (-4.3A)
None
None
None
 1.04A 5n5dA-5m8bA:
undetectable		 5n5dA-5m8bA:
21.70