SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5m8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		5 / 12 HIS A 281
GLY A 263
ASN A 265
GLY A 201
ASP A 139
 None
None
None
CA  A 401 ( 4.9A)
GOL  A 403 ( 3.9A)
 1.17A 1ffyA-5m8eA:
undetectable		 1ffyA-5m8eA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		4 / 8 GLU A 144
TYR A  19
TYR A  17
TRP A  84
 None
 1.20A 2aoxA-5m8eA:
undetectable		 2aoxA-5m8eA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		5 / 12 ARG A  59
ILE A  72
PHE A 107
ALA A 108
GLU A 120
 None
 0.99A 2j0dA-5m8eA:
undetectable		 2j0dA-5m8eA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		5 / 12 ARG A 207
PHE A 315
GLY A 316
VAL A 279
TYR A 280
 None
 1.20A 2nyrB-5m8eA:
undetectable		 2nyrB-5m8eA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		5 / 12 ASP A  15
ASP A 139
SER A 216
SER A 164
ALA A 154
 GOL  A 403 (-2.6A)
GOL  A 403 ( 3.9A)
None
None
None
 1.18A 3d91A-5m8eA:
undetectable		 3d91A-5m8eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		4 / 4 PHE A 267
TYR A 280
VAL A  86
LEU A  77
 None
 1.46A 3keeD-5m8eA:
undetectable		 3keeD-5m8eA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		4 / 8 PHE A  28
ILE A  18
ALA A  50
VAL A 279
 None
 0.88A 3me6B-5m8eA:
undetectable		 3me6B-5m8eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		5 / 12 SER A 216
LEU A 278
PHE A 267
PHE A 251
GLY A 263
 None
 1.29A 4pevC-5m8eA:
undetectable		 4pevC-5m8eA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		4 / 7 LEU A 138
PHE A 136
ILE A 160
ASN A 199
 GOL  A 404 (-4.3A)
GOL  A 404 (-4.0A)
None
None
 1.03A 5n5dA-5m8eA:
undetectable		 5n5dA-5m8eA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5m8e ALPHA-N-ARABINOFURAN
OSIDASE
(Weissella
cibaria) 		4 / 5 VAL A  29
PHE A 215
MET A 226
GLY A 217
 None
 1.40A 6hd4A-5m8eA:
undetectable		 6hd4A-5m8eA:
15.44